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ASB4 ankyrin repeat and SOCS box containing 4 [ Homo sapiens (human) ]

Gene ID: 51666, updated on 6-Jul-2026
Official Symbol
ASB4provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 4provided by HGNC
Primary source
HGNC:HGNC:16009
See related
Ensembl:ENSG00000005981 MIM:605761; AllianceGenome:HGNC:16009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASB-4
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 15.4) and placenta (RPKM 0.7) See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ASB4 in Genome Data Viewer
Location:
7q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (95470656..95551317)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (96722134..96790011)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (95115255..95169545)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:95005217-95006416 Neighboring gene paraoxonase 3 Neighboring gene uncharacterized LOC107986822 Neighboring gene paraoxonase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:95064127-95064697 Neighboring gene Sharpr-MPRA regulatory region 10642 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:95099762-95100961 Neighboring gene uncharacterized LOC107986822 Neighboring gene Sharpr-MPRA regulatory region 3033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:95156819-95157320 Neighboring gene uncharacterized LOC124901699 Neighboring gene Sharpr-MPRA regulatory region 6047 Neighboring gene pyruvate dehydrogenase kinase 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis. Wang Y, et al. Int J Mol Sci, 2024 Aug 20. PMID 39201703, Free PMC Article
  2. The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer. Miyamoto S, et al. Cancer Immunol Res, 2018 Mar. PMID 29371260
  3. Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits. Li JY, et al. J Neuroendocrinol, 2005 Jun. PMID 15929745
  4. The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2. Townley-Tilson WH, et al. PLoS One, 2014. PMID 24586788, Free PMC Article
  5. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. Li JY, et al. Cell Signal, 2007 Jun. PMID 17276034, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis.
    Title: The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis.
  2. This analysis identified an antigen, ASB4, which was processed and presented by a cancer stem cell (CSC) subset but not by non-CSCs. The ASB4 gene was expressed in CSCs of colorectal cancer, but not in cells that had differentiated into non-CSCs.ASB4 is a tumor-associated antigen that can elicit CTL responses specific to CSCs and can discriminate between two cellular subsets of colorectal cancer.
    Title: The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer.
  3. Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that rat Asb-4 is a gene involved in energy homeostasis.
    Title: Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC142039, MGC142041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul2-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cul5-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul5-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
Preferred Names
ankyrin repeat and SOCS box protein 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001445934.1 → NP_001432863.1  ankyrin repeat and SOCS box protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC003079

  2. NM_001445935.1 → NP_001432864.1  ankyrin repeat and SOCS box protein 4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC003079

  3. NM_001445936.1 → NP_001432865.1  ankyrin repeat and SOCS box protein 4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC003079

  4. NM_001445937.1 → NP_001432866.1  ankyrin repeat and SOCS box protein 4 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC002451, AC003079, AC005021
    UniProtKB/TrEMBL
    A0ACI8VBZ4

  5. NM_001445938.1 → NP_001432867.1  ankyrin repeat and SOCS box protein 4 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC002451, AC003079, AC004012, AC005021
    UniProtKB/TrEMBL
    A0ACI8RU79

  6. NM_001445939.1 → NP_001432868.1  ankyrin repeat and SOCS box protein 4 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC003079, AC004012, AC005021

  7. NM_016116.3 → NP_057200.1  ankyrin repeat and SOCS box protein 4 isoform a

    See identical proteins and their annotated locations for NP_057200.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC002451, AC003079, AF156779, AK096449, BC113479
    Consensus CDS
    CCDS5641.1
    UniProtKB/Swiss-Prot
    A4D1H6, O14586, Q14D68, Q8TBT2, Q9Y574
    UniProtKB/TrEMBL
    A0ACI8RU79
    Related
    ENSP00000321388.5, ENST00000325885.6
    Conserved Domains (3) summary
    PHA03095
    Location:80 → 321
    PHA03095; ankyrin-like protein; Provisional
    cd03723
    Location:379 → 426
    SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
    sd00045
    Location:77 → 104
    ANK; ANK repeat [structural motif]

  8. NM_145872.3 → NP_665879.1  ankyrin repeat and SOCS box protein 4 isoform b

    See identical proteins and their annotated locations for NP_665879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus which lacks a SOCS box domain compared to isoform a.
    Source sequence(s)
    BC025024, BC113479
    Consensus CDS
    CCDS5642.1
    UniProtKB/Swiss-Prot
    Q9Y574
    Related
    ENSP00000397070.1, ENST00000428113.5
    Conserved Domains (2) summary
    cd00204
    Location:77 → 191
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:77 → 104
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    95470656..95551317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420471.1 → XP_047276427.1  ankyrin repeat and SOCS box protein 4 isoform X2

    UniProtKB/TrEMBL
    A0ACI8RU79

  2. XM_017012303.2 → XP_016867792.1  ankyrin repeat and SOCS box protein 4 isoform X1

    UniProtKB/TrEMBL
    A0ACI8RU79

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    96722134..96790011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358389.1 → XP_054214364.1  ankyrin repeat and SOCS box protein 4 isoform X1

    UniProtKB/TrEMBL
    A0ACI8RU79
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y574.1 GenPept UniProtKB/Swiss-Prot:Q9Y574

Gene LinkOut

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