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FKBP7 FKBP prolyl isomerase 7 [ Homo sapiens (human) ]

Gene ID: 51661, updated on 1-Jun-2020

Summary

Official Symbol
FKBP7provided by HGNC
Official Full Name
FKBP prolyl isomerase 7provided by HGNC
Primary source
HGNC:HGNC:3723
See related
Ensembl:ENSG00000079150 MIM:607062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP23; PPIase
Summary
The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 13.6), endometrium (RPKM 9.0) and 21 other tissues See more
Orthologs

Genomic context

See FKBP7 in Genome Data Viewer
Location:
2q31.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (178463664..178480817, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (179328391..179343646, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cholesterol induced regulator of metabolism RNA Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene nuclear distribution C pseudogene 2 Neighboring gene pejvakin Neighboring gene pleckstrin homology domain containing A3 Neighboring gene TTN antisense RNA 1 Neighboring gene titin Neighboring gene uncharacterized LOC101927055

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP7
Names
23 kDa FK506-binding protein
23 kDa FKBP
FK506 binding protein 7
FK506-binding protein 23
FKBP-23
FKBP-7
PPIase FKBP7
rotamase
NP_001128684.1
NP_851939.1
XP_005246695.1
XP_011509650.1
XP_011509651.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135212.2NP_001128684.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform b precursor

    See identical proteins and their annotated locations for NP_001128684.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (b) is 1 amino acid shorter than isoform a.
    Source sequence(s)
    AA447628, AC009948, AY353086, BC009711, DA020387
    Consensus CDS
    CCDS46462.1
    UniProtKB/Swiss-Prot
    Q9Y680
    Related
    ENSP00000415486.2, ENST00000434643.6
    Conserved Domains (3) summary
    pfam00254
    Location:46140
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:151213
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:151212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_181342.3NP_851939.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform a precursor

    See identical proteins and their annotated locations for NP_851939.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA447628, AC009948, BC009711, DA020387
    Consensus CDS
    CCDS2280.1
    UniProtKB/Swiss-Prot
    Q9Y680
    Related
    ENSP00000413152.2, ENST00000424785.7
    Conserved Domains (2) summary
    pfam00254
    Location:46141
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:152214
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    178463664..178480817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246638.5XP_005246695.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1

    Conserved Domains (1) summary
    pfam00254
    Location:94175
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  2. XM_011511348.3XP_011509650.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X2

    Conserved Domains (3) summary
    pfam13499
    Location:45107
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:45106
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl19519
    Location:1734
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. XM_011511349.3XP_011509651.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform X3

    Conserved Domains (3) summary
    pfam13499
    Location:44106
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:44105
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl19519
    Location:1733
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016105.2: Suppressed sequence

    Description
    NM_016105.2: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a valid protein.
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