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GINS2 GINS complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 51659, updated on 7-Dec-2018

Summary

Official Symbol
GINS2provided by HGNC
Official Full Name
GINS complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:24575
See related
Ensembl:ENSG00000131153 MIM:610609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSF2; Pfs2; HSPC037
Summary
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Expression
Broad expression in bone marrow (RPKM 11.1), lymph node (RPKM 10.1) and 20 other tissues See more
Orthologs

Genomic context

See GINS2 in Genome Data Viewer
Location:
16q24.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (85677674..85688982, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (85711280..85722588, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Gse1 coiled-coil protein Neighboring gene uncharacterized LOC107984830 Neighboring gene uncharacterized LOC101928502 Neighboring gene RNA, 7SL, cytoplasmic 381, pseudogene Neighboring gene chromosome 16 open reading frame 74 Neighboring gene microRNA 1910 Neighboring gene RNA, U1 small nuclear 103, pseudogene Neighboring gene ER membrane protein complex subunit 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • DNA Replication, organism-specific biosystem (from REACTOME)
    DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
  • DNA strand elongation, organism-specific biosystem (from REACTOME)
    DNA strand elongation, organism-specific biosystemAccurate and efficient genome duplication requires coordinated processes to replicate two template strands at eucaryotic replication forks. Knowledge of the fundamental reactions involved in replicat...
  • GINS complex, organism-specific biosystem (from KEGG)
    GINS complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
  • GINS complex, conserved biosystem (from KEGG)
    GINS complex, conserved biosystemStructural complex; Genetic information processing; Replication system
  • S Phase, organism-specific biosystem (from REACTOME)
    S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
  • Synthesis of DNA, organism-specific biosystem (from REACTOME)
    Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
  • Unwinding of DNA, organism-specific biosystem (from REACTOME)
    Unwinding of DNA, organism-specific biosystemDNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M ph...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA strand elongation involved in DNA replication TAS
Traceable Author Statement
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA replication complex GINS protein PSF2
Names
GINS complex subunit 2 (Psf2 homolog)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016095.3NP_057179.1  DNA replication complex GINS protein PSF2

    See identical proteins and their annotated locations for NP_057179.1

    Status: VALIDATED

    Source sequence(s)
    AC123908, AF201939, BC010164
    Consensus CDS
    CCDS10953.1
    UniProtKB/Swiss-Prot
    Q9Y248
    Related
    ENSP00000253462.3, ENST00000253462.7
    Conserved Domains (1) summary
    cd11712
    Location:55174
    GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    85677674..85688982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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