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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001317785.2 → NP_001304714.1 serine/threonine/tyrosine-interacting-like protein 1 isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
- Source sequence(s)
-
AC006330, AF069762, BC024035, BM824947, BM972220
- Consensus CDS
-
CCDS5580.1
- UniProtKB/Swiss-Prot
- Q9UKG3, Q9Y6J8
- UniProtKB/TrEMBL
-
A0A024R4L1
- Related
- ENSP00000352726.3, ENST00000359697.8
- Conserved Domains (2) summary
-
- pfam00581
Location:22 → 135
- Rhodanese; Rhodanese-like domain
- cl21483
Location:160 → 297
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
NM_001317786.2 → NP_001304715.1 serine/threonine/tyrosine-interacting-like protein 1 isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
- Source sequence(s)
-
AC006330, AF069762, AL533027, BX537896
- Consensus CDS
-
CCDS5580.1
- UniProtKB/Swiss-Prot
- Q9UKG3, Q9Y6J8
- UniProtKB/TrEMBL
- A0A024R4L1, Q7Z3H6
- Related
- ENSP00000392221.1, ENST00000431581.5
- Conserved Domains (2) summary
-
- pfam00581
Location:22 → 135
- Rhodanese; Rhodanese-like domain
- cl21483
Location:160 → 297
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
NM_001317787.2 → NP_001304716.1 serine/threonine/tyrosine-interacting-like protein 1 isoform b
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, and lacks two consecutive in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform 1.
- Source sequence(s)
-
AC006330, AF069762, BX537896
- Consensus CDS
-
CCDS83193.1
- UniProtKB/Swiss-Prot
-
Q9Y6J8
- UniProtKB/TrEMBL
-
Q7Z3H6
- Related
- ENSP00000343383.5, ENST00000340062.9
- Conserved Domains (2) summary
-
- cl00125
Location:23 → 51
- RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
- cl21483
Location:64 → 201
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
NM_001317788.2 → NP_001304717.1 serine/threonine/tyrosine-interacting-like protein 1 isoform c
Status: VALIDATED
- Description
- Transcript Variant: This variant (5) lacks two exons in the 5' coding region, and uses an alternate splice site in the 3'coding region which results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform 1.
- Source sequence(s)
-
AC006330, AF069762, BM972220, BU859937
- UniProtKB/Swiss-Prot
-
Q9Y6J8
- Conserved Domains (2) summary
-
- cl00125
Location:23 → 51
- RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
- cl21483
Location:64 → 129
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
NM_001317789.1 → NP_001304718.1 serine/threonine/tyrosine-interacting-like protein 1 isoform d
Status: VALIDATED
- Description
- Transcript Variant: This variant (6) differs in its 5' UTR, lacks an exon in the 5' coding region, and uses an alternate downstream start codon which results in a frameshift, compared to variant 1. The encoded isoform (d) has a shorter and distinct N-terminus, compared to isoform 1.
- Source sequence(s)
-
AF188204, BM126964, BM972220, BX537896
- UniProtKB/Swiss-Prot
-
Q9Y6J8
- UniProtKB/TrEMBL
-
Q7Z3H6
- Conserved Domains (1) summary
-
- cl21483
Location:22 → 159
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
-
NM_016086.3 → NP_057170.1 serine/threonine/tyrosine-interacting-like protein 1 isoform a
See identical proteins and their annotated locations for NP_057170.1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) encodes isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
- Source sequence(s)
-
AA782050, AF069762, BC024035, BM824947
- Consensus CDS
-
CCDS5580.1
- UniProtKB/Swiss-Prot
- Q9UKG3, Q9Y6J8
- UniProtKB/TrEMBL
-
A0A024R4L1
- Related
- ENSP00000248600.1, ENST00000248600.5
- Conserved Domains (2) summary
-
- pfam00581
Location:22 → 135
- Rhodanese; Rhodanese-like domain
- cl21483
Location:160 → 297
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
RNA
-
NR_134486.2 RNA Sequence
Status: VALIDATED
- Description
- Transcript Variant: This variant (7) uses an alternate splice site in the 5'-terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
- Source sequence(s)
-
AF069762, AY927581, BI772699, BM972220
-
NR_134487.1 RNA Sequence
Status: VALIDATED
- Description
- Transcript Variant: This variant (8) lacks two exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
- Source sequence(s)
-
AF188201, BM126964, BM972220