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RASD1 ras related dexamethasone induced 1 [ Homo sapiens (human) ]

Gene ID: 51655, updated on 24-May-2020

Summary

Official Symbol
RASD1provided by HGNC
Official Full Name
ras related dexamethasone induced 1provided by HGNC
Primary source
HGNC:HGNC:15828
See related
Ensembl:ENSG00000108551 MIM:605550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGS1; DEXRAS1; MGC:26290
Summary
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]
Expression
Broad expression in fat (RPKM 57.3), kidney (RPKM 34.9) and 16 other tissues See more
Orthologs

Genomic context

See RASD1 in Genome Data Viewer
Location:
17p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (17494437..17496395, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17397751..17399709, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 15 pseudogene 1 Neighboring gene mediator complex subunit 9 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene VISTA enhancer hs1917 Neighboring gene RNA, U6 small nuclear 468, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dexamethasone-induced Ras-related protein 1
Names
RAS, dexamethasone-induced 1
activator of G-protein signaling 1
ras-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028074.1 RefSeqGene

    Range
    5001..6959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199989.2NP_001186918.1  dexamethasone-induced Ras-related protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001186918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS that results in a frame-shift compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073621
    Consensus CDS
    CCDS58519.1
    UniProtKB/Swiss-Prot
    Q9Y272
    Related
    ENSP00000463388.1, ENST00000579152.1
    Conserved Domains (1) summary
    cl21455
    Location:2595
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_016084.5NP_057168.1  dexamethasone-induced Ras-related protein 1 isoform 1 proprotein

    See identical proteins and their annotated locations for NP_057168.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073621
    Consensus CDS
    CCDS11185.1
    UniProtKB/Swiss-Prot
    Q9Y272
    Related
    ENSP00000225688.3, ENST00000225688.4
    Conserved Domains (1) summary
    cd04143
    Location:25281
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    17494437..17496395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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