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MRPS33 mitochondrial ribosomal protein S33 [ Homo sapiens (human) ]

Gene ID: 51650, updated on 5-Jul-2020

Summary

Official Symbol
MRPS33provided by HGNC
Official Full Name
mitochondrial ribosomal protein S33provided by HGNC
Primary source
HGNC:HGNC:16634
See related
Ensembl:ENSG00000090263 MIM:611993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S33mt; PTD003; CGI-139; MRP-S33
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 28.8), kidney (RPKM 25.5) and 25 other tissues See more
Orthologs

Genomic context

See MRPS33 in Genome Data Viewer
Location:
7q34
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (141002610..141014952, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140705961..140714781, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375536 Neighboring gene uncharacterized LOC107986720 Neighboring gene chaperonin containing TCP1 subunit 4 pseudogene 1 Neighboring gene uncharacterized LOC107986719 Neighboring gene RNA, U4 small nuclear 74, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
28S ribosomal protein S33, mitochondrial
Names
mitochondrial small ribosomal subunit protein mS33

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016071.4NP_057155.1  28S ribosomal protein S33, mitochondrial

    See identical proteins and their annotated locations for NP_057155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA743808, AC006006, AF151897, AI305281, AK024776, BP870829, W95986
    Consensus CDS
    CCDS5864.1
    UniProtKB/Swiss-Prot
    Q9Y291
    UniProtKB/TrEMBL
    A4D1T3
    Related
    ENSP00000376732.3, ENST00000393008.7
    Conserved Domains (1) summary
    pfam08293
    Location:691
    MRP-S33; Mitochondrial ribosomal subunit S27
  2. NM_053035.3NP_444263.1  28S ribosomal protein S33, mitochondrial

    See identical proteins and their annotated locations for NP_444263.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA743808, AC006006, AI305281, BC105793, BQ420818, W95986
    Consensus CDS
    CCDS5864.1
    UniProtKB/Swiss-Prot
    Q9Y291
    UniProtKB/TrEMBL
    A4D1T3, Q3KRB4
    Related
    ENSP00000320567.5, ENST00000324787.10
    Conserved Domains (1) summary
    pfam08293
    Location:691
    MRP-S33; Mitochondrial ribosomal subunit S27

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    141002610..141014952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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