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CIAO2B cytosolic iron-sulfur assembly component 2B [ Homo sapiens (human) ]

Gene ID: 51647, updated on 5-Apr-2020

Summary

Official Symbol
CIAO2Bprovided by HGNC
Official Full Name
cytosolic iron-sulfur assembly component 2Bprovided by HGNC
Primary source
HGNC:HGNC:24261
See related
Ensembl:ENSG00000166595 MIM:614778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIA2B; MIP18; FAM96B; CGI-128
Expression
Ubiquitous expression in kidney (RPKM 31.6), heart (RPKM 26.9) and 25 other tissues See more
Orthologs

Genomic context

See CIAO2B in Genome Data Viewer
Location:
16q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (66932065..66934402, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66965958..66968326, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cadherin 16 Neighboring gene RRAD, Ras related glycolysis inhibitor and calcium channel regulator Neighboring gene carboxylesterase 2 Neighboring gene uncharacterized LOC107984881

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 NL4-3 replication requires FAM96B as replication is inhibited when FAM96B is deleted through CRISPR/Cas9 genome editing PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 Tat is identified to have a physical interaction with family with sequence similarity 96, member B (FAM96B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation by [4Fe-4S] cluster transfer IEA
Inferred from Electronic Annotation
more info
 
protein maturation by iron-sulfur cluster transfer IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
CIA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CIA complex IDA
Inferred from Direct Assay
more info
PubMed 
MMXD complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytosolic iron-sulfur assembly component 2B
Names
MSS19-interacting protein of 18 kDa
family with sequence similarity 96 member B
mitotic spindle-associated MMXD complex subunit MIP18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016062.4NP_057146.1  cytosolic iron-sulfur assembly component 2B

    See identical proteins and their annotated locations for NP_057146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript but encodes the supported protein.
    Source sequence(s)
    AF151886, DA270099
    Consensus CDS
    CCDS45506.1
    UniProtKB/Swiss-Prot
    Q9Y3D0
    Related
    ENSP00000387471.2, ENST00000422424.7
    Conserved Domains (1) summary
    cl00941
    Location:23161
    DUF59; Domain of unknown function DUF59

RNA

  1. NR_024525.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the 5' region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF151886, DA270099, DR155511
    Related
    ENST00000563490.1
  2. NR_046109.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites in the 5' region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF151886, BI603322, DA270099
    Related
    ENST00000562362.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    66932065..66934402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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