U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

YPEL5 yippee like 5 [ Homo sapiens (human) ]

Gene ID: 51646, updated on 6-Sep-2022

Summary

Official Symbol
YPEL5provided by HGNC
Official Full Name
yippee like 5provided by HGNC
Primary source
HGNC:HGNC:18329
See related
Ensembl:ENSG00000119801 MIM:609726; AllianceGenome:HGNC:18329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-127
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 117.0), testis (RPKM 35.1) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See YPEL5 in Genome Data Viewer
Location:
2p23.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (30147007..30160533)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (30191259..30204786)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30369873..30383399)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ALK receptor tyrosine kinase Neighboring gene RNA, 7SL, cytoplasmic 516, pseudogene Neighboring gene uncharacterized LOC124907748 Neighboring gene uncharacterized LOC105374414 Neighboring gene uncharacterized LOC124907749 Neighboring gene Sharpr-MPRA regulatory region 12598 Neighboring gene small nucleolar RNA, H/ACA box 10B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitotic spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein yippee-like 5
NP_001120871.1
NP_001120872.1
NP_001120873.1
NP_057145.1
XP_016859807.1
XP_016859808.1
XP_016859809.1
XP_016859810.1
XP_016859811.1
XP_047300698.1
XP_047300699.1
XP_047300700.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127399.2NP_001120871.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Related
    ENSP00000383974.3, ENST00000402003.7
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  2. NM_001127400.2NP_001120872.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Related
    ENSP00000368834.3, ENST00000379519.7
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  3. NM_001127401.2NP_001120873.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Related
    ENSP00000368835.3, ENST00000379520.7
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  4. NM_016061.3NP_057145.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_057145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AF172940, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Related
    ENSP00000261353.4, ENST00000261353.9
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    30147007..30160533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004322.2XP_016859811.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Related
    ENSP00000385278.1, ENST00000402708.5
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  2. XM_047444743.1XP_047300699.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3C9
  3. XM_047444744.1XP_047300700.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3C9
  4. XM_017004318.2XP_016859807.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  5. XM_017004320.3XP_016859809.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  6. XM_047444742.1XP_047300698.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3C9
  7. XM_017004319.3XP_016859808.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  8. XM_017004321.2XP_016859810.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    30191259..30204786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)