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YPEL5 yippee like 5 [ Homo sapiens (human) ]

Gene ID: 51646, updated on 7-Jun-2020

Summary

Official Symbol
YPEL5provided by HGNC
Official Full Name
yippee like 5provided by HGNC
Primary source
HGNC:HGNC:18329
See related
Ensembl:ENSG00000119801 MIM:609726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-127
Expression
Ubiquitous expression in bone marrow (RPKM 117.0), testis (RPKM 35.1) and 24 other tissues See more
Orthologs

Genomic context

See YPEL5 in Genome Data Viewer
Location:
2p23.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (30146568..30160533)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30369750..30383399)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ALK receptor tyrosine kinase Neighboring gene uncharacterized LOC105374389 Neighboring gene RNA, 7SL, cytoplasmic 516, pseudogene Neighboring gene uncharacterized LOC101929418 Neighboring gene uncharacterized LOC105374414 Neighboring gene small nucleolar RNA, H/ACA box 10B Neighboring gene H3 histone pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein yippee-like 5
NP_001120871.1
NP_001120872.1
NP_001120873.1
NP_057145.1
XP_016859807.1
XP_016859808.1
XP_016859809.1
XP_016859810.1
XP_016859811.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127399.2NP_001120871.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699
    Related
    ENSP00000383974.3, ENST00000402003.7
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  2. NM_001127400.2NP_001120872.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699
    Related
    ENSP00000368834.3, ENST00000379519.7
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  3. NM_001127401.2NP_001120873.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699
    Related
    ENSP00000368835.3, ENST00000379520.7
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  4. NM_016061.3NP_057145.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_057145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AF172940, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    P62699
    Related
    ENSP00000261353.4, ENST00000261353.9
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    30146568..30160533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004318.1XP_016859807.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  2. XM_017004320.2XP_016859809.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  3. XM_017004319.2XP_016859808.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  4. XM_017004322.1XP_016859811.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699
    Related
    ENSP00000385278.1, ENST00000402708.5
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
  5. XM_017004321.1XP_016859810.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    P62699
    Conserved Domains (1) summary
    cl13152
    Location:15107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
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