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DHRS7 dehydrogenase/reductase 7 [ Homo sapiens (human) ]

Gene ID: 51635, updated on 5-Aug-2018

Summary

Official Symbol
DHRS7provided by HGNC
Official Full Name
dehydrogenase/reductase 7provided by HGNC
Primary source
HGNC:HGNC:21524
See related
Ensembl:ENSG00000100612 MIM:612833; Vega:OTTHUMG00000140331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-86; SDR34C1; retDSR4; retSDR4
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]
Expression
Broad expression in prostate (RPKM 116.8), small intestine (RPKM 40.2) and 22 other tissues See more
Orthologs

Genomic context

See DHRS7 in Genome Data Viewer
Location:
14q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (60144119..60169864, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60611496..60633034, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 9 Neighboring gene uncharacterized LOC105370524 Neighboring gene pecanex 4 Neighboring gene uncharacterized LOC107984631 Neighboring gene short coiled-coil protein pseudogene 1 Neighboring gene proteasome subunit alpha 3 pseudogene Neighboring gene ribosomal protein L17 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane HDA PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 7
Names
dehydrogenase/reductase (SDR family) member 7
retinal short-chain dehydrogenase/reductase 4
short chain dehydrogenase/reductase family 34C member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322280.1NP_001309209.1  dehydrogenase/reductase SDR family member 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Consensus CDS
    CCDS81810.1
    UniProtKB/Swiss-Prot
    Q9Y394
    Related
    ENSP00000442993.2, OTTHUMP00000245172, ENST00000536410.6, OTTHUMT00000411805
    Conserved Domains (2) summary
    cd05332
    Location:2258
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    COG0300
    Location:1268
    DltE; Short-chain dehydrogenase [General function prediction only]
  2. NM_001322281.1NP_001309210.1  dehydrogenase/reductase SDR family member 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Conserved Domains (1) summary
    cl21454
    Location:1168
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001322282.1NP_001309211.1  dehydrogenase/reductase SDR family member 7 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Conserved Domains (2) summary
    COG0300
    Location:51238
    DltE; Short-chain dehydrogenase [General function prediction only]
    cl21454
    Location:48228
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_016029.3NP_057113.1  dehydrogenase/reductase SDR family member 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057113.1

    Status: VALIDATED

    Source sequence(s)
    AL163853
    Consensus CDS
    CCDS9743.1
    UniProtKB/Swiss-Prot
    Q9Y394
    Related
    ENSP00000451882.1, ENST00000557185.5
    Conserved Domains (1) summary
    cd05332
    Location:48308
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    60144119..60169864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021368.2XP_016876857.1  dehydrogenase/reductase SDR family member 7 isoform X1

    Related
    ENSP00000450899.1, OTTHUMP00000246874, ENST00000554101.5
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