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OTUD6B OTU deubiquitinase 6B [ Homo sapiens (human) ]

Gene ID: 51633, updated on 1-Jun-2020

Summary

Official Symbol
OTUD6Bprovided by HGNC
Official Full Name
OTU deubiquitinase 6Bprovided by HGNC
Primary source
HGNC:HGNC:24281
See related
Ensembl:ENSG00000155100 MIM:612021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUBA5; CGI-77; DUBA-5; IDDFSDA
Summary
This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in brain (RPKM 6.6), testis (RPKM 5.6) and 25 other tissues See more
Orthologs

Genomic context

See OTUD6B in Genome Data Viewer
Location:
8q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (91070305..91087095)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92082424..92099323)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene OTUD6B antisense RNA 1 (head to head) Neighboring gene leucine rich repeat containing 69 Neighboring gene ceruloplasmin pseudogene Neighboring gene microRNA 4661

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human OTU domain containing 6B (OTUD6B) at amino acid residues 5-6 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
proteasome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
deubiquitinase OTUD6B
Names
OTU domain containing 6B
OTU domain-containing protein 6B
NP_001273674.1
NP_057107.4
XP_011515431.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286745.2NP_001273674.1  deubiquitinase OTUD6B isoform 2

    See identical proteins and their annotated locations for NP_001273674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC087439, AK293843, BQ000463
    Consensus CDS
    CCDS69513.1
    UniProtKB/Swiss-Prot
    Q8N6M0
    Related
    ENSP00000481196.1, ENST00000615618.1
    Conserved Domains (1) summary
    pfam02338
    Location:52177
    OTU; OTU-like cysteine protease
  2. NM_016023.5NP_057107.4  deubiquitinase OTUD6B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA748163, BC029760, BI712470, DA034027
    Consensus CDS
    CCDS6253.2
    Related
    ENSP00000384190.4, ENST00000404789.8
    Conserved Domains (2) summary
    COG5539
    Location:18280
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:153278
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    91070305..91087095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517129.2XP_011515431.2  deubiquitinase OTUD6B isoform X1

    UniProtKB/Swiss-Prot
    Q8N6M0
    Conserved Domains (1) summary
    pfam02338
    Location:52177
    OTU; OTU-like cysteine protease
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