U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OTUD6B OTU deubiquitinase 6B [ Homo sapiens (human) ]

Gene ID: 51633, updated on 3-May-2025
Official Symbol
OTUD6Bprovided by HGNC
Official Full Name
OTU deubiquitinase 6Bprovided by HGNC
Primary source
HGNC:HGNC:24281
See related
Ensembl:ENSG00000155100 MIM:612021; AllianceGenome:HGNC:24281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUBA5; CGI-77; DUBA-5; IDDFSDA
Summary
This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in brain (RPKM 6.6), testis (RPKM 5.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See OTUD6B in Genome Data Viewer
Location:
8q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (91070344..91087093)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (92195269..92212018)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92082572..92099321)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19355 Neighboring gene OTUD6B antisense RNA 1 (head to head) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27614 Neighboring gene MPRA-validated peak7106 silencer Neighboring gene leucine rich repeat containing 69 Neighboring gene ceruloplasmin pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:92209377-92209886 Neighboring gene microRNA 4661

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human OTU domain containing 6B (OTUD6B) at amino acid residues 5-6 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
deubiquitinase OTUD6B
Names
OTU domain containing 6B
OTU domain-containing protein 6B
NP_001273674.1
NP_001402951.1
NP_057107.4
XP_011515431.2
XP_047277820.1
XP_054216621.1
XP_054216622.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286745.3NP_001273674.1  deubiquitinase OTUD6B isoform 2

    See identical proteins and their annotated locations for NP_001273674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC087439, AK293843, BQ000463
    Consensus CDS
    CCDS69513.1
    UniProtKB/Swiss-Prot
    Q8N6M0
    Related
    ENSP00000481196.1, ENST00000615618.1
    Conserved Domains (1) summary
    pfam02338
    Location:52177
    OTU; OTU-like cysteine protease
  2. NM_001416022.1NP_001402951.1  deubiquitinase OTUD6B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087439
    UniProtKB/TrEMBL
    A0A087X0W9
  3. NM_016023.5NP_057107.4  deubiquitinase OTUD6B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA748163, BC029760, BI712470, DA034027
    Consensus CDS
    CCDS6253.3
    UniProtKB/Swiss-Prot
    A8K6I1, B4DEY0, Q8N6M0, Q9NTA4, Q9Y387
    UniProtKB/TrEMBL
    A0A087X0W9
    Related
    ENSP00000384190.4, ENST00000404789.8
    Conserved Domains (2) summary
    COG5539
    Location:18280
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:153278
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    91070344..91087093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421864.1XP_047277820.1  deubiquitinase OTUD6B isoform X2

  2. XM_011517129.3XP_011515431.2  deubiquitinase OTUD6B isoform X1

    UniProtKB/Swiss-Prot
    Q8N6M0
    Conserved Domains (1) summary
    pfam02338
    Location:52177
    OTU; OTU-like cysteine protease

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    92195269..92212018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360647.1XP_054216622.1  deubiquitinase OTUD6B isoform X2

  2. XM_054360646.1XP_054216621.1  deubiquitinase OTUD6B isoform X1