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UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) [ Homo sapiens (human) ]

Gene ID: 51619, updated on 6-Nov-2022

Summary

Official Symbol
UBE2D4provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 D4 (putative)provided by HGNC
Primary source
HGNC:HGNC:21647
See related
Ensembl:ENSG00000078967 AllianceGenome:HGNC:21647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBUCE1
Summary
Enables ubiquitin conjugating enzyme activity. Involved in protein polyubiquitination. Acts upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

See UBE2D4 in Genome Data Viewer
Location:
7p13
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (43926436..43956136)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44084736..44114438)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (43966035..43995735)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene URGCP-MRPS24 readthrough Neighboring gene uncharacterized LOC124901620 Neighboring gene upregulator of cell proliferation Neighboring gene tubulin gamma 1 pseudogene Neighboring gene RNA polymerase II subunit J4, pseudogene Neighboring gene speedy/RINGO cell cycle regulator family member E1 Neighboring gene Sharpr-MPRA regulatory region 7454

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 D4
Names
E2 ubiquitin-conjugating enzyme D4
ubiquitin carrier protein D4
ubiquitin conjugating enzyme E2D 4 (putative)
ubiquitin-conjugating enzyme HBUCE1
ubiquitin-protein ligase D4
NP_057067.1
XP_006715797.1
XP_024302563.1
XP_047276417.1
XP_047276418.1
XP_047276419.1
XP_047276420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015983.4NP_057067.1  ubiquitin-conjugating enzyme E2 D4

    See identical proteins and their annotated locations for NP_057067.1

    Status: VALIDATED

    Source sequence(s)
    AC004985, AW014299, BC004104, BG499454
    Consensus CDS
    CCDS5474.1
    UniProtKB/Swiss-Prot
    A4D1V0, Q9Y2X8
    UniProtKB/TrEMBL
    A0A024RA90
    Related
    ENSP00000222402.2, ENST00000222402.8
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    43926436..43956136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715734.4XP_006715797.1  ubiquitin-conjugating enzyme E2 D4 isoform X2

    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_047420461.1XP_047276417.1  ubiquitin-conjugating enzyme E2 D4 isoform X3

  3. XM_047420462.1XP_047276418.1  ubiquitin-conjugating enzyme E2 D4 isoform X4

  4. XM_047420463.1XP_047276419.1  ubiquitin-conjugating enzyme E2 D4 isoform X5

  5. XM_024446795.2XP_024302563.1  ubiquitin-conjugating enzyme E2 D4 isoform X1

    Conserved Domains (1) summary
    cl00154
    Location:54191
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  6. XM_047420464.1XP_047276420.1  ubiquitin-conjugating enzyme E2 D4 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    44084736..44114438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)