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NOP58 NOP58 ribonucleoprotein [ Homo sapiens (human) ]

Gene ID: 51602, updated on 5-Jul-2020

Summary

Official Symbol
NOP58provided by HGNC
Official Full Name
NOP58 ribonucleoproteinprovided by HGNC
Primary source
HGNC:HGNC:29926
See related
Ensembl:ENSG00000055044 MIM:616742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOP5; HSPC120; NOP5/NOP58
Summary
The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 29.6), lymph node (RPKM 29.1) and 25 other tissues See more
Orthologs

Genomic context

See NOP58 in Genome Data Viewer
Location:
2q33.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (202265763..202303661)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (203130515..203168384)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 1 Neighboring gene ribosomal protein L39 pseudogene 14 Neighboring gene short transmembrane mitochondrial protein 1 pseudogene Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene small nucleolar RNA, C/D box 70B Neighboring gene small nucleolar RNA, C/D box 11B Neighboring gene small nucleolar RNA, C/D box 11 Neighboring gene RNA, 7SL, cytoplasmic 753, pseudogene Neighboring gene PIMREG pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribonucleoprotein homolog (NOP58), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NOP58 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA binding HDA PubMed 
TFIID-class transcription factor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
rRNA processing TAS
Traceable Author Statement
more info
PubMed 
snoRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
box C/D snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
box C/D snoRNP complex NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
pre-snoRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
small nucleolar ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleolar protein 58
Names
NOP58 ribonucleoprotein homolog
nucleolar protein 5
nucleolar protein NOP5/NOP58

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015934.5NP_057018.1  nucleolar protein 58

    See identical proteins and their annotated locations for NP_057018.1

    Status: REVIEWED

    Source sequence(s)
    BC032592, BP245255
    Consensus CDS
    CCDS2353.1
    UniProtKB/Swiss-Prot
    Q9Y2X3
    Related
    ENSP00000264279.5, ENST00000264279.10
    Conserved Domains (2) summary
    pfam01798
    Location:168396
    Nop; snoRNA binding domain, fibrillarin
    pfam08156
    Location:266
    NOP5NT; NOP5NT (NUC127) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    202265763..202303661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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