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LSR lipolysis stimulated lipoprotein receptor [ Homo sapiens (human) ]

Gene ID: 51599, updated on 1-Jun-2020

Summary

Official Symbol
LSRprovided by HGNC
Official Full Name
lipolysis stimulated lipoprotein receptorprovided by HGNC
Primary source
HGNC:HGNC:29572
See related
Ensembl:ENSG00000105699 MIM:616582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILDR3; LISCH7
Expression
Broad expression in stomach (RPKM 52.0), colon (RPKM 51.5) and 22 other tissues See more
Orthologs

Genomic context

See LSR in Genome Data Viewer
Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35248656..35267964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35739290..35758867)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187 member B Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene uncharacterized LOC105372380 Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene HNF4 motif-containing MPRA enhancer 344

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10659, MGC48312, MGC48503

Gene Ontology Provided by GOA

Process Evidence Code Pubs
establishment of blood-brain barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
liver development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to tricellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
tricellular tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
chylomicron IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
tricellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lipolysis-stimulated lipoprotein receptor
Names
LISCH protein
immunoglobulin-like domain containing receptor 3
lipolysis-stimulated remnant
liver-specific bHLH-Zip transcription factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260489.1NP_001247418.1  lipolysis-stimulated lipoprotein receptor isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK126834, BM837160, BM971691, CF141732
    Consensus CDS
    CCDS59376.1
    UniProtKB/Swiss-Prot
    Q86X29
    Related
    ENSP00000472569.1, ENST00000602122.5
    Conserved Domains (1) summary
    pfam08648
    Location:490587
    DUF1777; Protein of unknown function (DUF1777)
  2. NM_001260490.1NP_001247419.1  lipolysis-stimulated lipoprotein receptor isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AK126834, AK296618, BM837160, BM971691
    UniProtKB/Swiss-Prot
    Q86X29
    Related
    ENSP00000394479.1, ENST00000427250.5
    Conserved Domains (2) summary
    PHA03307
    Location:202498
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR01622
    Location:419533
    SF-CC1; splicing factor, CC1-like family
  3. NM_015925.6NP_057009.3  lipolysis-stimulated lipoprotein receptor isoform 1

    See identical proteins and their annotated locations for NP_057009.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK126834, BC004381, BM837160, BM971691
    Consensus CDS
    CCDS12449.1
    UniProtKB/Swiss-Prot
    Q86X29
    Related
    ENSP00000346976.2, ENST00000354900.7
    Conserved Domains (1) summary
    pfam08648
    Location:491588
    DUF1777; Protein of unknown function (DUF1777)
  4. NM_205834.3NP_991403.1  lipolysis-stimulated lipoprotein receptor isoform 2

    See identical proteins and their annotated locations for NP_991403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AK126834, BC047376, BM971691
    Consensus CDS
    CCDS12450.1
    UniProtKB/Swiss-Prot
    Q86X29
    Related
    ENSP00000480821.1, ENST00000621372.4
    Conserved Domains (1) summary
    cl28033
    Location:310606
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  5. NM_205835.3NP_991404.1  lipolysis-stimulated lipoprotein receptor isoform 3

    See identical proteins and their annotated locations for NP_991404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK126834, AK130367, BM837160, BM971691
    Consensus CDS
    CCDS12451.1
    UniProtKB/Swiss-Prot
    Q86X29
    Related
    ENSP00000354034.2, ENST00000360798.7
    Conserved Domains (1) summary
    pfam08648
    Location:442539
    DUF1777; Protein of unknown function (DUF1777)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35248656..35267964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258980.2XP_005259037.1  lipolysis-stimulated lipoprotein receptor isoform X1

    Related
    ENSP00000262627.3, ENST00000347609.8
    Conserved Domains (1) summary
    pfam08648
    Location:509606
    DUF1777; Protein of unknown function (DUF1777)
  2. XM_011527026.2XP_011525328.1  lipolysis-stimulated lipoprotein receptor isoform X2

    Conserved Domains (1) summary
    pfam08648
    Location:461558
    DUF1777; Protein of unknown function (DUF1777)
  3. XM_005258982.2XP_005259039.1  lipolysis-stimulated lipoprotein receptor isoform X3

    Conserved Domains (1) summary
    PHA03307
    Location:242537
    PHA03307; transcriptional regulator ICP4; Provisional
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