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CUTA cutA divalent cation tolerance homolog [ Homo sapiens (human) ]

Gene ID: 51596, updated on 24-Nov-2020

Summary

Official Symbol
CUTAprovided by HGNC
Official Full Name
cutA divalent cation tolerance homologprovided by HGNC
Primary source
HGNC:HGNC:21101
See related
Ensembl:ENSG00000112514 MIM:616953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACHAP; C6orf82
Expression
Ubiquitous expression in thyroid (RPKM 52.9), adrenal (RPKM 52.0) and 25 other tissues See more
Orthologs

Genomic context

See CUTA in Genome Data Viewer
Location:
6p21.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (33416442..33418107, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33384319..33386111, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 4 Neighboring gene kinesin family member C1 Neighboring gene ribosomal protein L12 pseudogene 1 Neighboring gene PHD finger protein 1 Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene microRNA 5004 Neighboring gene zinc finger and BTB domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein localization IDA
Inferred from Direct Assay
more info
PubMed 
response to metal ion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein CutA
Names
acetylcholinesterase-associated protein
brain acetylcholinesterase putative membrane anchor
divalent cation tolerant protein CUTA

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014433.3NP_001014433.2  protein CutA isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform has also been named isoform a.
    Source sequence(s)
    AL662799, BX334868
    Consensus CDS
    CCDS34432.1
    Related
    ENSP00000363624.6, ENST00000374500.10
    Conserved Domains (1) summary
    pfam03091
    Location:48143
    CutA1; CutA1 divalent ion tolerance protein
  2. NM_001014837.2NP_001014837.1  protein CutA isoform 2 precursor

    See identical proteins and their annotated locations for NP_001014837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 has also been called isoform c. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF106943, AL533788, AL662799, BG472577, CN363642
    Consensus CDS
    CCDS4779.1
    UniProtKB/Swiss-Prot
    O60888
    Related
    ENSP00000363620.3, ENST00000374496.3
    Conserved Domains (1) summary
    pfam03091
    Location:48143
    CutA1; CutA1 divalent ion tolerance protein
  3. NM_001014838.2NP_001014838.1  protein CutA isoform 2 precursor

    See identical proteins and their annotated locations for NP_001014838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 has also been called isoform c. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF106943, AL533788, AL662799, BU540844
    Consensus CDS
    CCDS4779.1
    UniProtKB/Swiss-Prot
    O60888
    Related
    ENSP00000475963.1, ENST00000607266.5
    Conserved Domains (1) summary
    pfam03091
    Location:48143
    CutA1; CutA1 divalent ion tolerance protein
  4. NM_001014840.2NP_001014840.1  protein CutA isoform 3 precursor

    See identical proteins and their annotated locations for NP_001014840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 3). Isoform 3 has also been called isoform b.
    Source sequence(s)
    AF106943, AL662799, CB106834, CN363642
    Consensus CDS
    CCDS34433.1
    UniProtKB/Swiss-Prot
    O60888
    Related
    ENSP00000417544.1, ENST00000488034.5
    Conserved Domains (1) summary
    pfam03091
    Location:72166
    CutA1; CutA1 divalent ion tolerance protein
  5. NM_015921.3NP_057005.1  protein CutA isoform 2 precursor

    See identical proteins and their annotated locations for NP_057005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 has also been called isoform c. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF106943, AL533788, AL662799
    Consensus CDS
    CCDS4779.1
    UniProtKB/Swiss-Prot
    O60888
    Related
    ENSP00000403268.2, ENST00000440279.7
    Conserved Domains (1) summary
    pfam03091
    Location:48143
    CutA1; CutA1 divalent ion tolerance protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    33416442..33418107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    4865167..4866832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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