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SRRT serrate, RNA effector molecule [ Homo sapiens (human) ]

Gene ID: 51593, updated on 5-Sep-2021

Summary

Official Symbol
SRRTprovided by HGNC
Official Full Name
serrate, RNA effector moleculeprovided by HGNC
Primary source
HGNC:HGNC:24101
See related
Ensembl:ENSG00000087087 MIM:614469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARS2; ASR2; serrate
Expression
Broad expression in testis (RPKM 66.3), bone marrow (RPKM 37.2) and 25 other tissues See more
Orthologs
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Genomic context

See SRRT in Genome Data Viewer
Location:
7q22.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100874971..100888664)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100472725..100486285)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 9 Neighboring gene SLC12A9 antisense RNA 1 Neighboring gene uncharacterized LOC107986830 Neighboring gene microRNA 6875 Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene UFM1 specific peptidase 1 (inactive) Neighboring gene acetylcholinesterase (Cartwright blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies multiple loci related to resting heart rate.
GeneReviews: Not available
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of serrate RNA effector molecule homolog (SRRT) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA binding HDA PubMed 
enables mRNA cap binding complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to arsenic-containing substance NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serrate RNA effector molecule homolog
Names
arsenate resistance protein 2
arsenate resistance protein ARS2
arsenite resistance protein
arsenite-resistance protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128852.2NP_001122324.1  serrate RNA effector molecule homolog isoform c

    See identical proteins and their annotated locations for NP_001122324.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the end of a 5' exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AC011895, AL096723, DA611314
    Consensus CDS
    CCDS47666.1
    UniProtKB/Swiss-Prot
    Q9BXP5
    Related
    ENSP00000481173.1, ENST00000614484.4
    Conserved Domains (2) summary
    pfam04959
    Location:645850
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)
  2. NM_001128853.2NP_001122325.1  serrate RNA effector molecule homolog isoform d

    See identical proteins and their annotated locations for NP_001122325.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the end of a 3' exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is 4 aa shorter compared to isoform a.
    Source sequence(s)
    AF248955, BC109117, DA611314
    Consensus CDS
    CCDS47665.1
    UniProtKB/Swiss-Prot
    Q9BXP5
    Related
    ENSP00000478341.1, ENST00000618262.4
    Conserved Domains (2) summary
    pfam04959
    Location:646847
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)
  3. NM_001128854.2NP_001122326.1  serrate RNA effector molecule homolog isoform e

    See identical proteins and their annotated locations for NP_001122326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses alternate in-frame splice junctions at the ends of a 5' and 3' exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is 5 aa shorter compared to isoform a.
    Source sequence(s)
    AF248955, BC109117, DA611314
    Consensus CDS
    CCDS47667.1
    UniProtKB/Swiss-Prot
    Q9BXP5
    Related
    ENSP00000483556.1, ENST00000618411.4
    Conserved Domains (2) summary
    pfam04959
    Location:645846
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)
  4. NM_015908.6NP_056992.4  serrate RNA effector molecule homolog isoform a

    See identical proteins and their annotated locations for NP_056992.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC011895, AF248955, BC109116, DA611314
    Consensus CDS
    CCDS34709.1
    UniProtKB/Swiss-Prot
    Q9BXP5
    Related
    ENSP00000480421.1, ENST00000611405.5
    Conserved Domains (2) summary
    pfam04959
    Location:646851
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153262
    DUF3546; Domain of unknown function (DUF3546)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100874971..100888664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012290.1XP_016867779.1  serrate RNA effector molecule homolog isoform X6

  2. XM_017012291.1XP_016867780.1  serrate RNA effector molecule homolog isoform X7

  3. XM_024446794.1XP_024302562.1  serrate RNA effector molecule homolog isoform X8

    Conserved Domains (2) summary
    pfam04959
    Location:418619
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:135
    DUF3546; Domain of unknown function (DUF3546)
  4. XM_024446793.1XP_024302561.1  serrate RNA effector molecule homolog isoform X1

    Conserved Domains (2) summary
    pfam04959
    Location:680881
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:160269
    DUF3546; Domain of unknown function (DUF3546)
  5. XM_005250405.2XP_005250462.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:653858
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:160269
    DUF3546; Domain of unknown function (DUF3546)
  6. XM_005250407.2XP_005250464.1  serrate RNA effector molecule homolog isoform X4

    Conserved Domains (2) summary
    pfam04959
    Location:653854
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:160269
    DUF3546; Domain of unknown function (DUF3546)
  7. XM_005250406.2XP_005250463.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:652857
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:160269
    DUF3546; Domain of unknown function (DUF3546)
  8. XM_005250408.2XP_005250465.1  serrate RNA effector molecule homolog isoform X5

    Conserved Domains (2) summary
    pfam04959
    Location:652853
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:160269
    DUF3546; Domain of unknown function (DUF3546)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182800.2: Suppressed sequence

    Description
    NM_182800.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript, and it is a nonsense-mediated mRNA decay (NMD) candidate.
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