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PIAS4 protein inhibitor of activated STAT 4 [ Homo sapiens (human) ]

Gene ID: 51588, updated on 13-Mar-2020

Summary

Official Symbol
PIAS4provided by HGNC
Official Full Name
protein inhibitor of activated STAT 4provided by HGNC
Primary source
HGNC:HGNC:17002
See related
Ensembl:ENSG00000105229 MIM:605989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIASY; Piasg; ZMIZ6; PIAS-gamma
Expression
Broad expression in testis (RPKM 14.8), spleen (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See PIAS4 in Genome Data Viewer
Location:
19p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4007736..4039386)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4007749..4038067)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene death associated protein kinase 3 Neighboring gene microRNA 637 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene zinc finger and BTB domain containing 7A Neighboring gene mitogen-activated protein kinase kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12419, MGC35296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
SUMO transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
SUMO transferase activity TAS
Traceable Author Statement
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vitamin D metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transferase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS4
Names
RING-type E3 ubiquitin transferase PIAS4
protein inhibitor of activated STAT protein 4
protein inhibitor of activated STAT protein PIASy
protein inhibitor of activated STAT protein gamma
zinc finger, MIZ-type containing 6
NP_056981.2
XP_011526362.1
XP_016882357.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015897.4NP_056981.2  E3 SUMO-protein ligase PIAS4

    See identical proteins and their annotated locations for NP_056981.2

    Status: VALIDATED

    Source sequence(s)
    AC016586
    Consensus CDS
    CCDS12118.1
    UniProtKB/Swiss-Prot
    Q8N2W9
    UniProtKB/TrEMBL
    B3KMR4
    Related
    ENSP00000262971.1, ENST00000262971.3
    Conserved Domains (3) summary
    smart00513
    Location:1246
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:322371
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:131269
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4007736..4039386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528060.2XP_011526362.1  E3 SUMO-protein ligase PIAS4 isoform X1

    Conserved Domains (3) summary
    smart00513
    Location:3165
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:341390
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:150288
    PINIT; PINIT domain
  2. XM_017026868.1XP_016882357.1  E3 SUMO-protein ligase PIAS4 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016149.1: Suppressed sequence

    Description
    NM_016149.1: This RefSeq was permanently suppressed because the CDS is partial.
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