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MED15 mediator complex subunit 15 [ Homo sapiens (human) ]

Gene ID: 51586, updated on 26-Apr-2020

Summary

Official Symbol
MED15provided by HGNC
Official Full Name
mediator complex subunit 15provided by HGNC
Primary source
HGNC:HGNC:14248
See related
Ensembl:ENSG00000099917 MIM:607372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105
Summary
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See MED15 in Genome Data Viewer
Location:
22q11.21
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20507582..20587621)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20861849..20941919)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 22 Neighboring gene keratin 18 pseudogene 5 Neighboring gene uncharacterized LOC101928824 Neighboring gene coiled-coil domain containing 74B pseudogene 1 Neighboring gene sphingomyelin phosphodiesterase 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 15 (MED15) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42282, FLJ42935, DKFZp686A2214, DKFZp762B1216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
mediator complex IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 15
Names
CTG repeat protein 7a
PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
PC2 glutamine/Q-rich-associated protein
PC2-glutamine-rich-associated protein
TPA inducible gene-1
TPA inducible protein
TPA-inducible gene 1 protein
activator-recruited cofactor 105 kDa component
activator-recruited cofactor, 105-kD
positive cofactor 2, glutamine/Q-rich-associated protein
trinucleotide repeat containing 7
trinucleotide repeat-containing gene 7 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003891.3NP_001003891.1  mediator of RNA polymerase II transcription subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001003891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK090465, BC003078, BC005027
    Consensus CDS
    CCDS33602.1
    UniProtKB/Swiss-Prot
    Q96RN5
    UniProtKB/TrEMBL
    Q6PKB8
    Related
    ENSP00000263205.7, ENST00000263205.11
    Conserved Domains (1) summary
    pfam09606
    Location:17784
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. NM_001293234.2NP_001280163.1  mediator of RNA polymerase II transcription subunit 15 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AK315540, BC005027
    Conserved Domains (1) summary
    pfam09606
    Location:17727
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. NM_001293235.2NP_001280164.1  mediator of RNA polymerase II transcription subunit 15 isoform d

    See identical proteins and their annotated locations for NP_001280164.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
    Source sequence(s)
    BC003078, BC005027, BC013985, DA182752
    Consensus CDS
    CCDS77653.1
    UniProtKB/Swiss-Prot
    Q96RN5
    UniProtKB/TrEMBL
    G3V1P5, Q6PKB8
    Related
    ENSP00000384344.1, ENST00000406969.5
    Conserved Domains (1) summary
    pfam09606
    Location:1718
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  4. NM_001293236.2NP_001280165.1  mediator of RNA polymerase II transcription subunit 15 isoform e

    See identical proteins and their annotated locations for NP_001280165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform e) is shorter, compared to isoform a.
    Source sequence(s)
    BC003078, BC005027, CR456537, DA182752
    Consensus CDS
    CCDS74824.1
    UniProtKB/Swiss-Prot
    Q96RN5
    UniProtKB/TrEMBL
    Q6PKB8
    Related
    ENSP00000372434.2, ENST00000382974.6
    Conserved Domains (1) summary
    pfam09606
    Location:17673
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  5. NM_001293237.2NP_001280166.1  mediator of RNA polymerase II transcription subunit 15 isoform d

    See identical proteins and their annotated locations for NP_001280166.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
    Source sequence(s)
    AC007731, AK294734, BC005027, CB156495
    Consensus CDS
    CCDS77653.1
    UniProtKB/TrEMBL
    B7Z2H7, G3V1P5
    Conserved Domains (1) summary
    pfam09606
    Location:1718
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. NM_015889.5NP_056973.2  mediator of RNA polymerase II transcription subunit 15 isoform b

    See identical proteins and their annotated locations for NP_056973.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC005027, BC013985, DA182752
    Consensus CDS
    CCDS13781.1
    UniProtKB/Swiss-Prot
    Q96RN5
    Related
    ENSP00000292733.7, ENST00000292733.11
    Conserved Domains (1) summary
    pfam09606
    Location:17744
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20507582..20587621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530218.3XP_011528520.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    Conserved Domains (1) summary
    pfam09606
    Location:17361
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. XM_011530220.3XP_011528522.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    See identical proteins and their annotated locations for XP_011528522.1

    Conserved Domains (1) summary
    pfam09606
    Location:17149
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. XM_011530219.2XP_011528521.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    See identical proteins and their annotated locations for XP_011528521.1

    Conserved Domains (1) summary
    pfam09606
    Location:17149
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  4. XM_017028821.2XP_016884310.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

RNA

  1. XR_002958699.1 RNA Sequence

  2. XR_002958702.1 RNA Sequence

  3. XR_002958698.1 RNA Sequence

  4. XR_002958692.1 RNA Sequence

  5. XR_002958695.1 RNA Sequence

    Related
    ENST00000433831.5
  6. XR_002958703.1 RNA Sequence

  7. XR_002958697.1 RNA Sequence

  8. XR_002958693.1 RNA Sequence

  9. XR_002958701.1 RNA Sequence

  10. XR_002958694.1 RNA Sequence

  11. XR_002958700.1 RNA Sequence

  12. XR_002958696.1 RNA Sequence

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