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MED15 mediator complex subunit 15 [ Homo sapiens (human) ]

Gene ID: 51586, updated on 25-Jan-2024

Summary

Official Symbol
MED15provided by HGNC
Official Full Name
mediator complex subunit 15provided by HGNC
Primary source
HGNC:HGNC:14248
See related
Ensembl:ENSG00000099917 MIM:607372; AllianceGenome:HGNC:14248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105
Summary
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues See more
Orthologs
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Genomic context

See MED15 in Genome Data Viewer
Location:
22q11.21
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20507610..20587619)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20916219..20996263)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20861897..20941906)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 22 Neighboring gene keratin 18 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13496 Neighboring gene uncharacterized LOC101928824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20850596-20851248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20859501-20860000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18680 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20884447-20885434 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62783 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20903520-20904510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62813 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18682 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62834 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62844 Neighboring gene uncharacterized LOC124905084 Neighboring gene coiled-coil domain containing 74B pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20954774-20954964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20964690-20965288 Neighboring gene sphingomyelin phosphodiesterase 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 15 (MED15) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ42282, FLJ42935, DKFZp686A2214, DKFZp762B1216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 15
Names
CTG repeat protein 7a
PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
PC2 glutamine/Q-rich-associated protein
PC2-glutamine-rich-associated protein
TPA inducible gene-1
TPA inducible protein
TPA-inducible gene 1 protein
activator-recruited cofactor 105 kDa component
activator-recruited cofactor, 105-kD
positive cofactor 2, glutamine/Q-rich-associated protein
trinucleotide repeat containing 7
trinucleotide repeat-containing gene 7 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003891.3NP_001003891.1  mediator of RNA polymerase II transcription subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001003891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK090465, BC003078, BC005027
    Consensus CDS
    CCDS33602.1
    UniProtKB/Swiss-Prot
    D3DX31, D3DX32, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q96RN5, Q9P1T3
    UniProtKB/TrEMBL
    B7Z2H7
    Related
    ENSP00000263205.7, ENST00000263205.11
    Conserved Domains (1) summary
    pfam09606
    Location:17784
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. NM_001293234.2NP_001280163.1  mediator of RNA polymerase II transcription subunit 15 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AK315540, BC005027
    UniProtKB/TrEMBL
    B7Z2H7
    Conserved Domains (1) summary
    pfam09606
    Location:17727
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. NM_001293235.2NP_001280164.1  mediator of RNA polymerase II transcription subunit 15 isoform d

    See identical proteins and their annotated locations for NP_001280164.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
    Source sequence(s)
    BC003078, BC005027, BC013985, DA182752
    Consensus CDS
    CCDS77653.1
    UniProtKB/TrEMBL
    B7Z2H7, G3V1P5
    Related
    ENSP00000384344.1, ENST00000406969.5
    Conserved Domains (1) summary
    pfam09606
    Location:1718
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  4. NM_001293236.2NP_001280165.1  mediator of RNA polymerase II transcription subunit 15 isoform e

    See identical proteins and their annotated locations for NP_001280165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform e) is shorter, compared to isoform a.
    Source sequence(s)
    BC003078, BC005027, CR456537, DA182752
    Consensus CDS
    CCDS74824.1
    UniProtKB/TrEMBL
    B7Z2H7
    Related
    ENSP00000372434.2, ENST00000382974.6
    Conserved Domains (1) summary
    pfam09606
    Location:1778
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  5. NM_001293237.2NP_001280166.1  mediator of RNA polymerase II transcription subunit 15 isoform d

    See identical proteins and their annotated locations for NP_001280166.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
    Source sequence(s)
    AC007731, AK294734, BC005027, CB156495
    Consensus CDS
    CCDS77653.1
    UniProtKB/TrEMBL
    B7Z2H7, G3V1P5
    Conserved Domains (1) summary
    pfam09606
    Location:1718
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. NM_015889.5NP_056973.2  mediator of RNA polymerase II transcription subunit 15 isoform b

    See identical proteins and their annotated locations for NP_056973.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC005027, BC013985, DA182752
    Consensus CDS
    CCDS13781.1
    UniProtKB/TrEMBL
    B7Z2H7
    Related
    ENSP00000292733.7, ENST00000292733.11
    Conserved Domains (1) summary
    pfam09606
    Location:17744
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20507610..20587619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441395.1XP_047297351.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    UniProtKB/TrEMBL
    B7Z2H7
  2. XM_047441398.1XP_047297354.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    UniProtKB/TrEMBL
    B7Z2H7, G3V1P5
  3. XM_047441401.1XP_047297357.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

    UniProtKB/TrEMBL
    B4DGD6
  4. XM_047441399.1XP_047297355.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

    UniProtKB/TrEMBL
    B4DGD6
  5. XM_011530219.3XP_011528521.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

    See identical proteins and their annotated locations for XP_011528521.1

    Conserved Domains (1) summary
    pfam09606
    Location:17149
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  6. XM_011530218.4XP_011528520.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

    Conserved Domains (1) summary
    pfam09606
    Location:17361
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  7. XM_017028821.3XP_016884310.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

  8. XM_047441396.1XP_047297352.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    UniProtKB/TrEMBL
    B7Z2H7
  9. XM_047441402.1XP_047297358.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

    UniProtKB/TrEMBL
    B7Z2H7
  10. XM_047441397.1XP_047297353.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    UniProtKB/TrEMBL
    B7Z2H7
  11. XM_047441400.1XP_047297356.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

    UniProtKB/TrEMBL
    B7Z2H7
  12. XM_047441403.1XP_047297359.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

    UniProtKB/TrEMBL
    B3KW62, B3KWF1, Q69YR4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20916219..20996263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325677.1XP_054181652.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    UniProtKB/TrEMBL
    B7Z2H7
  2. XM_054325680.1XP_054181655.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    UniProtKB/TrEMBL
    B7Z2H7, G3V1P5
  3. XM_054325683.1XP_054181658.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

    UniProtKB/TrEMBL
    B4DGD6
  4. XM_054325681.1XP_054181656.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

    UniProtKB/TrEMBL
    B4DGD6
  5. XM_054325687.1XP_054181662.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

  6. XM_054325686.1XP_054181661.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

  7. XM_054325685.1XP_054181660.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

  8. XM_054325678.1XP_054181653.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    UniProtKB/TrEMBL
    B7Z2H7
  9. XM_054325684.1XP_054181659.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

    UniProtKB/TrEMBL
    B7Z2H7
  10. XM_054325679.1XP_054181654.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    UniProtKB/TrEMBL
    B7Z2H7
  11. XM_054325682.1XP_054181657.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

    UniProtKB/TrEMBL
    B7Z2H7
  12. XM_054325688.1XP_054181663.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

    UniProtKB/TrEMBL
    B3KW62, B3KWF1, Q69YR4