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GDE1 glycerophosphodiester phosphodiesterase 1 [ Homo sapiens (human) ]

Gene ID: 51573, updated on 5-Jul-2025
Official Symbol
GDE1provided by HGNC
Official Full Name
glycerophosphodiester phosphodiesterase 1provided by HGNC
Primary source
HGNC:HGNC:29644
See related
Ensembl:ENSG00000006007 MIM:605943; AllianceGenome:HGNC:29644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR16; 363E6.2
Summary
Predicted to enable glycerophosphodiester phosphodiesterase activity; glycerophosphoinositol glycerophosphodiesterase activity; and phosphatidylcholine lysophospholipase activity. Predicted to be involved in N-acylethanolamine metabolic process; ethanolamine metabolic process; and phospholipid metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in colon (RPKM 28.1), fat (RPKM 25.8) and 25 other tissues See more
Orthologs
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See GDE1 in Genome Data Viewer
Location:
16p12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (19501693..19522098, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (19432571..19452970, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19513015..19533420, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transmembrane channel like 5 Neighboring gene TMC5 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19499330-19500018 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:19507832-19508043 Neighboring gene RNA, U4 small nuclear 46, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10530 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:19532887-19533621 Neighboring gene centriolar coiled-coil protein 110 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19566659-19567621 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:19620544-19621743 Neighboring gene NANOG hESC enhancer GRCh37_chr16:19673654-19674240 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:19698132-19698632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19710103-19710758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19710759-19711413

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycerophosphodiester phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycerophosphodiester phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycerophosphodiester phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glycerophosphodiester phosphodiesterase activity TAS
Traceable Author Statement
more info
PubMed 
enables glycerophosphoinositol glycerophosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycerophosphoinositol glycerophosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glycerophosphoinositol glycerophosphodiesterase activity TAS
Traceable Author Statement
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine lysophospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in N-acylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within N-acylethanolamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in N-acylethanolamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ethanolamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ethanolamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycerophospholipid catabolic process TAS
Traceable Author Statement
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
glycerophosphodiester phosphodiesterase 1
Names
RGS16-interacting membrane protein
glycerophosphoinositol glycerophosphodiesterase GDE1
lysophospholipase D GDE1
membrane interacting protein of RGS16
NP_001310995.1
NP_001310996.1
NP_057725.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324066.2NP_001310995.1  glycerophosphodiester phosphodiesterase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC003108, AC012621, AC130456
    Conserved Domains (1) summary
    cd08573
    Location:1213
    GDPD_GDE1; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins
  2. NM_001324067.2NP_001310996.1  glycerophosphodiester phosphodiesterase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC003108, AC012621, AC130456
    UniProtKB/TrEMBL
    B2R7B1
    Conserved Domains (2) summary
    cd08573
    Location:68292
    GDPD_GDE1; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins
    pfam03009
    Location:70275
    GDPD; Glycerophosphoryl diester phosphodiesterase family
  3. NM_016641.4NP_057725.1  glycerophosphodiester phosphodiesterase 1 isoform 1

    See identical proteins and their annotated locations for NP_057725.1

    Status: VALIDATED

    Source sequence(s)
    AF306698, BC012153, BQ897064
    Consensus CDS
    CCDS10578.1
    UniProtKB/Swiss-Prot
    O43334, Q6PKF7, Q7KYR4, Q9NZC3
    UniProtKB/TrEMBL
    B2R7B1
    Related
    ENSP00000261386.3, ENST00000353258.8
    Conserved Domains (1) summary
    cd08573
    Location:68323
    GDPD_GDE1; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins

RNA

  1. NR_136689.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003108, AC012621, AC130456

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    19501693..19522098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    19432571..19452970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)