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TDP2 tyrosyl-DNA phosphodiesterase 2 [ Homo sapiens (human) ]

Gene ID: 51567, updated on 5-Aug-2018
Official Symbol
TDP2provided by HGNC
Official Full Name
tyrosyl-DNA phosphodiesterase 2provided by HGNC
Primary source
HGNC:HGNC:17768
See related
Ensembl:ENSG00000111802 MIM:605764; Vega:OTTHUMG00000014360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAP2; AD022; EAPII; TTRAP; hTDP2; dJ30M3.3
Summary
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 97.5), colon (RPKM 87.6) and 24 other tissues See more
Orthologs
See TDP2 in Genome Data Viewer
Location:
6p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (24649977..24666887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24650205..24667115, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene aldehyde dehydrogenase 5 family member A1 Neighboring gene KIAA0319 Neighboring gene keratin 8 pseudogene 43 Neighboring gene acyl-CoA thioesterase 13 Neighboring gene chromosome 6 open reading frame 62 Neighboring gene uncharacterized LOC105374978 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol TTRAP and HIV-1 IN interact in vivo and in vitro. The interaction involves the first 180 amino acids of TTRAP PubMed

Go to the HIV-1, Human Interaction Database

  • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
    CD40/CD40L signaling, organism-specific biosystem
    CD40/CD40L signaling
  • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
    DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Nonhomologous End-Joining (NHEJ), organism-specific biosystem (from REACTOME)
    Nonhomologous End-Joining (NHEJ), organism-specific biosystemThe nonhomologous end joining (NHEJ) pathway is initiated in response to the formation of DNA double-strand breaks (DSBs) induced by DNA-damaging agents, such as ionizing radiation. DNA DSBs are reco...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9099, MGC111021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-tyrosyl-DNA phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5'-tyrosyl-DNA phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
5'-tyrosyl-DNA phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding TAS
Traceable Author Statement
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
tyrosyl-RNA phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
aggresome IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tyrosyl-DNA phosphodiesterase 2
Names
5'-Tyr-DNA phosphodiesterase
5'-tyrosyl-DNA phosphodiesterase
ETS1-associated protein 2
ETS1-associated protein II
TRAF and TNF receptor-associated protein
VPg unlinkase
tyr-DNA phosphodiesterase 2
tyrosyl-RNA phosphodiesterase
NP_057698.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052787.1 RefSeqGene

    Range
    5001..21911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016614.2NP_057698.2  tyrosyl-DNA phosphodiesterase 2

    See identical proteins and their annotated locations for NP_057698.2

    Status: REVIEWED

    Source sequence(s)
    BC017553
    Consensus CDS
    CCDS4557.1
    UniProtKB/Swiss-Prot
    O95551
    Related
    ENSP00000367440.4, OTTHUMP00000016091, ENST00000378198.8, OTTHUMT00000040012
    Conserved Domains (2) summary
    cd09080
    Location:114358
    TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains
    cd14344
    Location:2763
    UBA_TYDP2; UBA-like domain found in tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    24649977..24666887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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