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TDP2 tyrosyl-DNA phosphodiesterase 2 [ Homo sapiens (human) ]

Gene ID: 51567, updated on 20-Sep-2020

Summary

Official Symbol
TDP2provided by HGNC
Official Full Name
tyrosyl-DNA phosphodiesterase 2provided by HGNC
Primary source
HGNC:HGNC:17768
See related
Ensembl:ENSG00000111802 MIM:605764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAP2; AD022; EAPII; TTRAP; hTDP2; dJ30M3.3
Summary
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 97.5), colon (RPKM 87.6) and 24 other tissues See more
Orthologs

Genomic context

See TDP2 in Genome Data Viewer
Location:
6p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (24649979..24666899, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24650205..24667115, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene aldehyde dehydrogenase 5 family member A1 Neighboring gene KIAA0319 Neighboring gene keratin 8 pseudogene 43 Neighboring gene Sharpr-MPRA regulatory region 5933 Neighboring gene acyl-CoA thioesterase 13 Neighboring gene chromosome 6 open reading frame 62 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene long intergenic non-protein coding RNA 2828

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol TTRAP and HIV-1 IN interact in vivo and in vitro. The interaction involves the first 180 amino acids of TTRAP PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9099, MGC111021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-tyrosyl-DNA phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5'-tyrosyl-DNA phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
5'-tyrosyl-DNA phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding TAS
Traceable Author Statement
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
tyrosyl-RNA phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
aggresome IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosyl-DNA phosphodiesterase 2
Names
5'-Tyr-DNA phosphodiesterase
5'-tyrosyl-DNA phosphodiesterase
ETS1-associated protein 2
ETS1-associated protein II
TRAF and TNF receptor-associated protein
VPg unlinkase
epididymis secretory sperm binding protein
tyr-DNA phosphodiesterase 2
tyrosyl-RNA phosphodiesterase
NP_057698.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052787.1 RefSeqGene

    Range
    4989..21909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016614.3NP_057698.2  tyrosyl-DNA phosphodiesterase 2

    See identical proteins and their annotated locations for NP_057698.2

    Status: REVIEWED

    Source sequence(s)
    AL031775
    Consensus CDS
    CCDS4557.1
    UniProtKB/Swiss-Prot
    O95551
    Related
    ENSP00000367440.4, ENST00000378198.9
    Conserved Domains (2) summary
    cd09080
    Location:114358
    TDP2; Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains
    cd14344
    Location:2763
    UBA_TYDP2; UBA-like domain found in tyrosyl-DNA phosphodiesterase 2 (TDP2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    24649979..24666899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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