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IL1R1 interleukin 1 receptor type 1 [ Bos taurus (domestic cattle) ]

Gene ID: 515640, updated on 30-Jan-2025
Official Symbol
IL1R1provided by VGNC
Official Full Name
interleukin 1 receptor type 1provided by VGNC
Primary source
VGNC:VGNC:30131
See related
BGD:BT10714; EnsemblRapid:ENSBTAG00070034894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See IL1R1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (6781808..6915249)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112448746 Neighboring gene interleukin 1 receptor type 2 Neighboring gene small nucleolar RNA SNORD86 Neighboring gene uncharacterized LOC132346540 Neighboring gene uncharacterized LOC112448943 Neighboring gene N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2-like

Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Assignment of interleukin-1 receptor, type I (IL1R1) to bovine chromosome band 11q12 by in situ hybridization. Castiglioni B, et al. Cytogenet Cell Genet, 2000. PMID 10965115
  2. Expression and localization of interleukin 1 beta and interleukin 1 receptor (type I) in the bovine endometrium and embryo. Correia-Álvarez E, et al. J Reprod Immunol, 2015 Aug. PMID 25955718
  3. Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cells. Murayama C, et al. Cell Biol Int, 2010 Apr 8. PMID 20156197
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 protein and IL1B and IL1R1 mRNA were detected.
    Title: Expression and localization of interleukin 1 beta and interleukin 1 receptor (type I) in the bovine endometrium and embryo.
  2. Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.
    Title: Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cells.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables interleukin-1 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-1 receptor type 1
Names
interleukin 1 receptor, alpha; type I receptor
NP_001193664.1
XP_005212498.1
XP_005212499.1
XP_024854368.1
XP_024854370.1
XP_024854373.1
XP_024854374.1
XP_024854375.1
XP_059747203.1
XP_059747204.1
XP_059747205.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206735.1 → NP_001193664.1  interleukin-1 receptor type 1 precursor

    See identical proteins and their annotated locations for NP_001193664.1

    Status: VALIDATED

    Source sequence(s)
    DV924922, EE359059, NKLS02000011
    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Related
    ENSBTAP00070047794.1, ENSBTAT00070078418.1
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    6781808..6915249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059891221.1 → XP_059747204.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75

  2. XM_059891220.1 → XP_059747203.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75

  3. XM_024998607.2 → XP_024854375.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

  4. XM_024998605.2 → XP_024854373.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

  5. XM_005212441.5 → XP_005212498.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005212498.1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

  6. XM_024998600.2 → XP_024854368.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

  7. XM_024998606.2 → XP_024854374.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

  8. XM_024998602.2 → XP_024854370.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

  9. XM_059891222.1 → XP_059747205.1  interleukin-1 receptor type 1 isoform X2

  10. XM_005212442.5 → XP_005212499.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005212499.1

    UniProtKB/TrEMBL
    A0AAA9T7H5, F1ML75
    Conserved Domains (4) summary
    smart00255
    Location:384 → 540
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:225 → 316
    Ig_3; Immunoglobulin domain
    cd05757
    Location:128 → 219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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