IL23A interleukin 23 subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL23Aprovided by HGNC
Official Full Name: interleukin 23 subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:15488
See related: Ensembl:ENSG00000110944 MIM:605580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P19; SGRF; IL-23; IL-23A; IL23P19
Summary: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 12q13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109.20191205	current	GRCh38.p13 (GCF_000001405.39)	12	NC_000012.12 (56334159..56340410)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (56732663..56734194)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cervical cancer cells differentially regulate IL23 and IL12 in DC fibroblast cocultures in an IL6/C/EBPbeta/IL1beta-dependent manner, thereby supporting the expansion of Th17 cells during cancer progression
Title: Cervical Cancer-Instructed Stromal Fibroblasts Enhance IL23 Expression in Dendritic Cells to Support Expansion of Th17 Cells.
the IL-23 alpha-subunit remains partially unstructured until assembly with its beta-subunit occurs and identify a major site of incomplete folding.
Title: The molecular basis of chaperone-mediated interleukin 23 assembly control.
We found increased IL-23 and IL-1beta expression in the Hashimoto thyroiditis group but not in the Graves disease group
Title: Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto's thyroiditis but not in Graves' disease.
The data of this study suggests that other factors in cohesion with the genetic background contribute to the responsiveness of the IL-6/STAT3, IL-12/STAT4, and IL-23/STAT3-pathways.
Title: IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis.
Macrophages increase PDAC primary pancreatic ductal adenocarcinoma growth and metastases formation while combined IL23 and TGF-ss pre-treatment diminishes these processes.
Title: IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma.
in this study IL-23 showed pro-inflammatory properties in the liver transplant rejected patients
Title: Evaluation of Interleukin-21, 23 and 27 mRNA Expression and Protein Level in Liver Transplant Patients.
Low IL23A expression is associated with brain metastasis in lung cancer.
Title: Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial.
rs2066808 polymorphism located near the IL-23A gene could increase the genetic risk of premature coronary artery disease in Mexican population.
Title: The rs2066808 Polymorphism Located Near the <i>IL-23A</i> Gene Is Associated with Premature Coronary Artery Disease in Mexican Population (GEA Study).
IL-23-regulated miRNAs in T cells from patients with ankylosing spondylitis (AS) could alter the expression of downstream target molecules and thereby contribute to the immunopathogenesis of AS.
Title: Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis.
Persistent IL-23 generation of liver inflammatory macrophages responding to damaged hepatocytes after chronic hepatitis B virus (HBV) infection altered macrophage function for hepatocellular carcinoma promotion.
Title: IL-23 production of liver inflammatory macrophages to damaged hepatocytes promotes hepatocellular carcinoma development after chronic hepatitis B virus infection.

Submit: New GeneRIF Correction See all GeneRIFs (257)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SOCS1 protein expression is upregulated in T cells cultured with HIV-1 gp120-treated myeloid dendritic cell medium but is significantly inhibited in the presence of anti-IL-23 antibody	PubMed
	env	Levels of IL-23A in LPS-treated myeloid dendritic cells are upregulated in the presence of HIV-1 gp120	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482436

RH92829 (e-PCR)
- UniSTS:85712

PMC321570P2 (e-PCR)
- UniSTS:273116

Homology

Homologs of the IL23A gene: The IL23A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 169 organisms have orthologs with human gene IL23A
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
interleukin-23 receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-23 receptor binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
T cell proliferation	IEA Inferred from Electronic Annotation more info
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
defense response to virus	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info
interleukin-23-mediated signaling pathway	TAS Traceable Author Statement more info
negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NIK/NF-kappaB signaling	TAS Traceable Author Statement more info	PubMed
positive regulation of NK T cell activation	IC Inferred by Curator more info	PubMed
positive regulation of NK T cell activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NK T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T-helper 1 type immune response	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T-helper 1 type immune response	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 1 type immune response	NAS Non-traceable Author Statement more info	PubMed
positive regulation of T-helper 1 type immune response	TAS Traceable Author Statement more info	PubMed
positive regulation of T-helper 17 cell lineage commitment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 17 type immune response	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of activation of Janus kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of activation of Janus kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of inflammatory response	IC Inferred by Curator more info	PubMed
positive regulation of interferon-gamma production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interferon-gamma production	TAS Traceable Author Statement more info	PubMed
positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-10 production	TAS Traceable Author Statement more info	PubMed
positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of memory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of natural killer cell activation	IC Inferred by Curator more info	PubMed
positive regulation of natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
positive regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tissue remodeling	IC Inferred by Curator more info	PubMed
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
tissue remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum lumen	TAS Traceable Author Statement more info
extracellular region	TAS Traceable Author Statement more info
interleukin-23 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
interleukin-23 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-23 subunit alpha

Names: IL-23 subunit alpha; IL-23-A; IL-23p19; JKA3 induced upon T-cell activation; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit p19; interleukin-six, G-CSF related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.