IL23A interleukin 23 subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL23Aprovided by HGNC
Official Full Name: interleukin 23 subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:15488
See related: Ensembl:ENSG00000110944 MIM:605580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P19; SGRF; IL-23; IL-23A; IL23P19
Summary: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	12	NC_000012.12 (56334159..56340410)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (56732668..56734194)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circulating interleukin-23 levels in ankylosing spondylitis and their correlation with disease activity : A meta-analysis.", trans "Werte fur zirkulierendes Interleukin-23 bei Spondylitis ankylosans und Korrelation mit der Krankheitsaktivitat : Eine Metaanalyse.
Title: Circulating interleukin-23 levels in ankylosing spondylitis and their correlation with disease activity : A meta-analysis.
Association of IL-17 and IL-23 follicular fluid concentrations and gene expression profile in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome.
Title: Association of IL-17 and IL-23 follicular fluid concentrations and gene expression profile in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome.
CD4+ and CD25+ T-cell response to short-time interferon-beta therapy on IL10, IL23A and FOXP3 genes in multiple sclerosis patients.
Title: CD4+ and CD25+ T-cell response to short-time interferon-beta therapy on IL10, IL23A and FOXP3 genes in multiple sclerosis patients.
Activation of adenosine A2A receptor induced interleukin-23 mRNA expression in macrophages of ankylosing spondylitis patients.
Title: Activation of adenosine A<sub>2A</sub> receptor induced interleukin-23 mRNA expression in macrophages of ankylosing spondylitis patients.
The role of the interleukin-23/Th17 pathway in cardiometabolic comorbidity associated with psoriasis.
Title: The role of the interleukin-23/Th17 pathway in cardiometabolic comorbidity associated with psoriasis.
Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression.
Title: Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression.
IL-12 and IL-23-Close Relatives with Structural Homologies but Distinct Immunological Functions.
Title: IL-12 and IL-23-Close Relatives with Structural Homologies but Distinct Immunological Functions.
High interleukin-18 and low FOXP3 mRNAs in peripheral blood of women with severe systemic lupus erythematosus: a cross-sectional study.
Title: High interleukin-18 and low FOXP3 mRNAs in peripheral blood of women with severe systemic lupus erythematosus: a cross-sectional study.
LEVELS OF PROINFLAMMATORY CYTOKINES IL-17 AND IL-23 IN PATIENTS WITH ALZHEIMER'S DISEASE, MILD COGNITIVE IMPAIRMENT AND VASCULAR DEMENTIA.
Title: LEVELS OF PROINFLAMMATORY CYTOKINES IL-17 AND IL-23 IN PATIENTS WITH ALZHEIMER'S DISEASE, MILD COGNITIVE IMPAIRMENT AND VASCULAR DEMENTIA.
Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation.
Title: Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (285)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. GeneReviews: Not available
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. GeneReviews: Not available
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SOCS1 protein expression is upregulated in T cells cultured with HIV-1 gp120-treated myeloid dendritic cell medium but is significantly inhibited in the presence of anti-IL-23 antibody	PubMed
	env	Levels of IL-23A in LPS-treated myeloid dendritic cells are upregulated in the presence of HIV-1 gp120	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482436

RH92829 (e-PCR)
- UniSTS:85712

PMC321570P2 (e-PCR)
- UniSTS:273116

Homology

Homologs of the IL23A gene: The IL23A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 231 organisms have orthologs with human gene IL23A
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-23 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NIK/NF-kappaB signaling	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of NK T cell activation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of NK T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NK T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 1 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 1 type immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 1 type immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T-helper 1 type immune response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of T-helper 17 cell lineage commitment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 17 type immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of activation of Janus kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of activation of Janus kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	IC Inferred by Curator more info	PubMed
involved_in positive regulation of interferon-gamma production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-gamma production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-10 production	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of memory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of natural killer cell activation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tissue remodeling	IC Inferred by Curator more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tissue remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
part_of interleukin-23 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of interleukin-23 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-23 subunit alpha

Names: IL-23 subunit alpha; IL-23-A; IL-23p19; JKA3 induced upon T-cell activation; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit p19; interleukin-six, G-CSF related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.