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IL23A interleukin 23 subunit alpha [ Homo sapiens (human) ]

Gene ID: 51561, updated on 24-Sep-2024

Summary

Official Symbol
IL23Aprovided by HGNC
Official Full Name
interleukin 23 subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:15488
See related
Ensembl:ENSG00000110944 MIM:605580; AllianceGenome:HGNC:15488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P19; SGRF; IL-23; IL-23A; IL23P19
Summary
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues See more
Orthologs
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Genomic context

See IL23A in Genome Data Viewer
Location:
12q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56338884..56340410)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56306530..56308056)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56732668..56734194)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CNPY2 antisense RNA 1 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56709757-56710345 Neighboring gene MPRA-validated peak1742 silencer Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56730556-56731403 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:56731981-56733180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29688 Neighboring gene signal transducer and activator of transcription 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4558 Neighboring gene RNA, U7 small nuclear 40 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6495 Neighboring gene apolipoprotein F

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
EBI GWAS Catalog
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
EBI GWAS Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SOCS1 protein expression is upregulated in T cells cultured with HIV-1 gp120-treated myeloid dendritic cell medium but is significantly inhibited in the presence of anti-IL-23 antibody PubMed
env Levels of IL-23A in LPS-treated myeloid dendritic cells are upregulated in the presence of HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC79388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-23 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway via STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NK T cell activation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of NK T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NK T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T-helper 1 type immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of T-helper 17 cell lineage commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T-helper 17 type immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-10 production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of memory T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell activation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of natural killer cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tissue remodeling IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type II interferon production TAS
Traceable Author Statement
more info
PubMed 
involved_in tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
part_of interleukin-23 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of interleukin-23 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-23 subunit alpha
Names
IL-23 subunit alpha
IL-23-A
IL-23p19
JKA3 induced upon T-cell activation
interleukin 23 p19 subunit
interleukin 23, alpha subunit p19
interleukin-23 subunit p19
interleukin-six, G-CSF related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016584.3NP_057668.1  interleukin-23 subunit alpha precursor

    See identical proteins and their annotated locations for NP_057668.1

    Status: REVIEWED

    Source sequence(s)
    AB030000, BM842783
    Consensus CDS
    CCDS8916.1
    UniProtKB/Swiss-Prot
    Q6NZ80, Q6NZ82, Q9H2A5, Q9NPF7
    Related
    ENSP00000228534.4, ENST00000228534.6
    Conserved Domains (1) summary
    pfam16649
    Location:28184
    IL23; Interleukin 23 subunit alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56338884..56340410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56306530..56308056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)