IL23A interleukin 23 subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL23Aprovided by HGNC
Official Full Name: interleukin 23 subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:15488
See related: Ensembl:ENSG00000110944 MIM:605580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P19; SGRF; IL-23; IL-23A; IL23P19
Summary: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 12q13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109.20190905	current	GRCh38.p13 (GCF_000001405.39)	12	NC_000012.12 (56334159..56340410)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (56732663..56734194)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophages increase PDAC primary pancreatic ductal adenocarcinoma growth and metastases formation while combined IL23 and TGF-ss pre-treatment diminishes these processes.
Title: IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma.
in this study IL-23 showed pro-inflammatory properties in the liver transplant rejected patients
Title: Evaluation of Interleukin-21, 23 and 27 mRNA Expression and Protein Level in Liver Transplant Patients.
Low IL23A expression is associated with brain metastasis in lung cancer.
Title: Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial.
rs2066808 polymorphism located near the IL-23A gene could increase the genetic risk of premature coronary artery disease in Mexican population.
Title: The rs2066808 Polymorphism Located Near the <i>IL-23A</i> Gene Is Associated with Premature Coronary Artery Disease in Mexican Population (GEA Study).
IL-23-regulated miRNAs in T cells from patients with ankylosing spondylitis (AS) could alter the expression of downstream target molecules and thereby contribute to the immunopathogenesis of AS.
Title: Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis.
Persistent IL-23 generation of liver inflammatory macrophages responding to damaged hepatocytes after chronic hepatitis B virus (HBV) infection altered macrophage function for hepatocellular carcinoma promotion.
Title: IL-23 production of liver inflammatory macrophages to damaged hepatocytes promotes hepatocellular carcinoma development after chronic hepatitis B virus infection.
these data propose that, in humans, strength of TCR/CD28/Akt activation serves as a rheostat tuning the magnitude of Th17 development driven by IL-23 and IL-1beta.
Title: IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation.
IL-12 and IL-23 heterodimers are increased in Giant-cell arteritis (GCA) lesions and decrease with glucocorticoid treatment. p19 and p35 subunits are much more abundant than p40, indicating an independent role for these subunits or their potential association with alternative subunits.
Title: Expression and Function of IL12/23 Related Cytokine Subunits (p35, p40, and p19) in Giant-Cell Arteritis Lesions: Contribution of p40 to Th1- and Th17-Mediated Inflammatory Pathways.
Genetically determined high activities of the TNF-alpha, IL23/IL17, and NF-kappaB pathways were associated with increased risk of ankylosing spondylitis.
Title: Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis.
LMO4 appears to mediate IL-23-related responses in psoriatic keratinocytes and is a potential therapeutic target in psoriasis.
Title: LMO4 Is a Disease-Provocative Transcription Coregulator Activated by IL-23 in Psoriatic Keratinocytes.

Submit: New GeneRIF Correction See all GeneRIFs (253)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SOCS1 protein expression is upregulated in T cells cultured with HIV-1 gp120-treated myeloid dendritic cell medium but is significantly inhibited in the presence of anti-IL-23 antibody	PubMed
	env	Levels of IL-23A in LPS-treated myeloid dendritic cells are upregulated in the presence of HIV-1 gp120	PubMed

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Pathways from BioSystems

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ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
ATF-2 transcription factor network, organism-specific biosystem
ATF-2 transcription factor network
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Development and heterogeneity of the ILC family, organism-specific biosystem (from WikiPathways)
Development and heterogeneity of the ILC family, organism-specific biosystemDevelopment and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription f...
IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL23-mediated signaling events, organism-specific biosystem
IL23-mediated signaling events
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Th17 cell differentiation, organism-specific biosystem (from KEGG)
Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Th17 cell differentiation, conserved biosystem (from KEGG)
Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482436

RH92829 (e-PCR)
- UniSTS:85712

PMC321570P2 (e-PCR)
- UniSTS:273116

Homology

Homologs of the IL23A gene: The IL23A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 166 organisms have orthologs with human gene IL23A
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
interleukin-23 receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to interleukin-23 receptor binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
T cell proliferation	IEA Inferred from Electronic Annotation more info
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
defense response to virus	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info
interleukin-23-mediated signaling pathway	TAS Traceable Author Statement more info
negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NIK/NF-kappaB signaling	TAS Traceable Author Statement more info	PubMed
positive regulation of NK T cell activation	IC Inferred by Curator more info	PubMed
positive regulation of NK T cell activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NK T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T-helper 1 type immune response	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T-helper 1 type immune response	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 1 type immune response	NAS Non-traceable Author Statement more info	PubMed
positive regulation of T-helper 1 type immune response	TAS Traceable Author Statement more info	PubMed
positive regulation of T-helper 17 cell lineage commitment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 17 type immune response	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of activation of Janus kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of activation of Janus kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of inflammatory response	IC Inferred by Curator more info	PubMed
positive regulation of interferon-gamma production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interferon-gamma production	TAS Traceable Author Statement more info	PubMed
positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-10 production	TAS Traceable Author Statement more info	PubMed
positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of memory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of natural killer cell activation	IC Inferred by Curator more info	PubMed
positive regulation of natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
positive regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tissue remodeling	IC Inferred by Curator more info	PubMed
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
tissue remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum lumen	TAS Traceable Author Statement more info
extracellular region	TAS Traceable Author Statement more info
interleukin-23 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
interleukin-23 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-23 subunit alpha

Names: IL-23 subunit alpha; IL-23-A; IL-23p19; JKA3 induced upon T-cell activation; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit p19; interleukin-six, G-CSF related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.