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NT5DC3 5'-nucleotidase domain containing 3 [ Homo sapiens (human) ]

Gene ID: 51559, updated on 1-Jun-2020

Summary

Official Symbol
NT5DC3provided by HGNC
Official Full Name
5'-nucleotidase domain containing 3provided by HGNC
Primary source
HGNC:HGNC:30826
See related
Ensembl:ENSG00000111696 MIM:611076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TU12B1TY; TU12B1-TY
Expression
Broad expression in bone marrow (RPKM 4.0), brain (RPKM 3.1) and 24 other tissues See more
Orthologs

Genomic context

See NT5DC3 in Genome Data Viewer
Location:
12q23.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (103746315..103841239, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104166081..104234975, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2401 Neighboring gene stabilin 2 Neighboring gene uncharacterized LOC105369946 Neighboring gene uncharacterized LOC107984433 Neighboring gene tetratricopeptide repeat domain 41, pseudogene Neighboring gene uncharacterized LOC107984130

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention.
NHGRI GWA Catalog
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5'-nucleotidase domain-containing protein 3
NP_001026871.1
XP_011536778.1
XP_016874943.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031701.3NP_001026871.1  5'-nucleotidase domain-containing protein 3

    See identical proteins and their annotated locations for NP_001026871.1

    Status: VALIDATED

    Source sequence(s)
    AC012555, AC025265, BC052293
    Consensus CDS
    CCDS41824.1
    UniProtKB/Swiss-Prot
    Q86UY8
    Related
    ENSP00000376615.3, ENST00000392876.8
    Conserved Domains (1) summary
    pfam05761
    Location:93526
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    103746315..103841239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538476.2XP_011536778.1  5'-nucleotidase domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    pfam05761
    Location:24379
    5_nucleotid; 5' nucleotidase family
  2. XM_017019454.1XP_016874943.1  5'-nucleotidase domain-containing protein 3 isoform X2

RNA

  1. XR_001748758.1 RNA Sequence

  2. XR_001748756.1 RNA Sequence

  3. XR_944574.2 RNA Sequence

  4. XR_001748757.1 RNA Sequence

  5. XR_001748760.2 RNA Sequence

  6. XR_001748759.1 RNA Sequence

  7. XR_944581.2 RNA Sequence

  8. XR_944580.2 RNA Sequence

  9. XR_944582.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016575.1: Suppressed sequence

    Description
    NM_016575.1: This RefSeq was permanently suppressed because the CDS was partial; the full-length CDS is already represented by NM_001031701.1.
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