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PEX5L peroxisomal biogenesis factor 5 like [ Homo sapiens (human) ]

Gene ID: 51555, updated on 15-Jun-2019

Summary

Official Symbol
PEX5Lprovided by HGNC
Official Full Name
peroxisomal biogenesis factor 5 likeprovided by HGNC
Primary source
HGNC:HGNC:30024
See related
Ensembl:ENSG00000114757 MIM:611058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PXR2; PEX5R; PXR2B; PEX5RP; TRIP8b
Expression
Biased expression in brain (RPKM 6.5), testis (RPKM 0.6) and 1 other tissue See more
Orthologs

Genomic context

See PEX5L in Genome Data Viewer
Location:
3q26.33
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (179794958..180037053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (179512746..179754841, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986158 Neighboring gene NADH:ubiquinone oxidoreductase subunit B5 Neighboring gene ubiquitin specific peptidase 13 Neighboring gene PEX5L antisense RNA 2 Neighboring gene RNA, 5S ribosomal pseudogene 149 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of peroxisomal biogenesis factor 5-like (PEX5L; PXR2B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761J2017

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peroxisome matrix targeting signal-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome targeting sequence binding IDA
Inferred from Direct Assay
more info
PubMed 
small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein import into peroxisome matrix, docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PEX5-related protein
Names
HCN channel auxiliary subunit
PEX2-related protein
PEX5-like protein
Pex5p-related protein
peroxin-5-related protein
peroxisome biogenesis factor 5-like
tetratricopeptide repeat-containing Rab8b-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256750.2NP_001243679.1  PEX5-related protein isoform 2

    See identical proteins and their annotated locations for NP_001243679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform 2.
    Source sequence(s)
    AB032592, AC007687, DA772743
    Consensus CDS
    CCDS58866.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000263962.8, ENST00000263962.12
    Conserved Domains (4) summary
    COG0457
    Location:264537
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:472500
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:509539
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:508569
    TPR_11; TPR repeat
  2. NM_001256751.2NP_001243680.1  PEX5-related protein isoform 3

    See identical proteins and their annotated locations for NP_001243680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AB032593, AC007687, AK299633, DA772743
    Consensus CDS
    CCDS58865.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000419348.1, ENST00000465751.5
    Conserved Domains (4) summary
    COG0457
    Location:242515
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:450478
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:487517
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:486547
    TPR_11; TPR repeat
  3. NM_001256752.2NP_001243681.1  PEX5-related protein isoform 4

    See identical proteins and their annotated locations for NP_001243681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform 4.
    Source sequence(s)
    AB032592, AC007687, BC036183, DA772743
    Consensus CDS
    CCDS58867.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000418440.1, ENST00000485199.5
    Conserved Domains (4) summary
    COG0457
    Location:231504
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:439467
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:476506
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:475536
    TPR_11; TPR repeat
  4. NM_001256753.2NP_001243682.1  PEX5-related protein isoform 5

    See identical proteins and their annotated locations for NP_001243682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform 5.
    Source sequence(s)
    AB032593, AC007687, AK294501, DA772743
    Consensus CDS
    CCDS58864.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000418054.1, ENST00000472994.5
    Conserved Domains (4) summary
    COG0457
    Location:207480
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:415443
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:452482
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:451512
    TPR_11; TPR repeat
  5. NM_001256754.2NP_001243683.1  PEX5-related protein isoform 6

    See identical proteins and their annotated locations for NP_001243683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 18, encodes isoform 6.
    Source sequence(s)
    AC007687, AC092939, AK295386, AK303716
    Consensus CDS
    CCDS58863.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000420555.1, ENST00000476138.5
    Conserved Domains (2) summary
    sd00006
    Location:431459
    TPR; TPR repeat [structural motif]
    cl26002
    Location:288518
    TPR_11; TPR repeat
  6. NM_001256755.2NP_001243684.1  PEX5-related protein isoform 7

    See identical proteins and their annotated locations for NP_001243684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 7.
    Source sequence(s)
    AC007687, AC092939, AK295349, AK295386, AK303716
    Consensus CDS
    CCDS58862.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000417270.1, ENST00000464614.5
    Conserved Domains (2) summary
    sd00006
    Location:366394
    TPR; TPR repeat [structural motif]
    cl26002
    Location:223453
    TPR_11; TPR repeat
  7. NM_001256756.2NP_001243685.1  PEX5-related protein isoform 8

    See identical proteins and their annotated locations for NP_001243685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 22-28, encodes isoform 8.
    Source sequence(s)
    AB032593, AC007687, AC092939, AK295386
    Consensus CDS
    CCDS58861.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000418665.1, ENST00000468741.5
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  8. NM_001349386.2NP_001336315.1  PEX5-related protein isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes the longest isoform (9).
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:529557
    TPR; TPR repeat [structural motif]
    cl26002
    Location:386616
    TPR_11; TPR repeat
  9. NM_001349387.2NP_001336316.1  PEX5-related protein isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 10.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:498526
    TPR; TPR repeat [structural motif]
    cl26002
    Location:355585
    TPR_11; TPR repeat
  10. NM_001349388.2NP_001336317.1  PEX5-related protein isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 10.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:498526
    TPR; TPR repeat [structural motif]
    cl26002
    Location:355585
    TPR_11; TPR repeat
  11. NM_001349389.2NP_001336318.1  PEX5-related protein isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes isoform 11.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:496524
    TPR; TPR repeat [structural motif]
    cl26002
    Location:353583
    TPR_11; TPR repeat
  12. NM_001349390.2NP_001336319.1  PEX5-related protein isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) encodes isoform 12.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:494522
    TPR; TPR repeat [structural motif]
    cl26002
    Location:351581
    TPR_11; TPR repeat
  13. NM_001349391.2NP_001336320.1  PEX5-related protein isoform 13

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) encodes isoform 13.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:464492
    TPR; TPR repeat [structural motif]
    cl26002
    Location:321551
    TPR_11; TPR repeat
  14. NM_001349392.2NP_001336321.1  PEX5-related protein isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 14.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:463491
    TPR; TPR repeat [structural motif]
    cl26002
    Location:320550
    TPR_11; TPR repeat
  15. NM_001349393.2NP_001336322.1  PEX5-related protein isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 14.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:463491
    TPR; TPR repeat [structural motif]
    cl26002
    Location:320550
    TPR_11; TPR repeat
  16. NM_001349394.2NP_001336323.1  PEX5-related protein isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) encodes isoform 15.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:433461
    TPR; TPR repeat [structural motif]
    cl26002
    Location:290520
    TPR_11; TPR repeat
  17. NM_001349395.2NP_001336324.1  PEX5-related protein isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variant 6, encodes isoform 6.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58863.1
    Conserved Domains (2) summary
    sd00006
    Location:431459
    TPR; TPR repeat [structural motif]
    cl26002
    Location:288518
    TPR_11; TPR repeat
  18. NM_001349396.2NP_001336325.1  PEX5-related protein isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) encodes isoform 16.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:407435
    TPR; TPR repeat [structural motif]
    cl26002
    Location:264494
    TPR_11; TPR repeat
  19. NM_001349397.2NP_001336326.1  PEX5-related protein isoform 17

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) encodes isoform 17.
    Source sequence(s)
    AC007687, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:398426
    TPR; TPR repeat [structural motif]
    cl26002
    Location:255485
    TPR_11; TPR repeat
  20. NM_001349398.2NP_001336327.1  PEX5-related protein isoform 18

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) encodes isoform 18.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Conserved Domains (2) summary
    sd00006
    Location:385413
    TPR; TPR repeat [structural motif]
    cl26002
    Location:242472
    TPR_11; TPR repeat
  21. NM_001349399.2NP_001336328.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 8 and 23-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Consensus CDS
    CCDS58861.1
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  22. NM_001349401.2NP_001336330.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 8, 22, and 24-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Consensus CDS
    CCDS58861.1
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  23. NM_001349404.2NP_001336333.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variants 8, 22, 23, and 25-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC090024, AC092939
    Consensus CDS
    CCDS58861.1
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  24. NM_001349406.2NP_001336335.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variants 8, 22-24, and 26-28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  25. NM_001349408.2NP_001336337.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26), as well as variants 8, 22-25, 27, and 28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  26. NM_001349409.2NP_001336338.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27), as well as variants 8, 22-26, and 28, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  27. NM_001349410.2NP_001336339.1  PEX5-related protein isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variants 8 and 22-27, encodes isoform 8.
    Source sequence(s)
    AC007687, AC092939
    Consensus CDS
    CCDS58861.1
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  28. NM_016559.3NP_057643.1  PEX5-related protein isoform 1

    See identical proteins and their annotated locations for NP_057643.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB032593, AC007687, DA772743
    Consensus CDS
    CCDS3236.1
    UniProtKB/Swiss-Prot
    Q8IYB4
    Related
    ENSP00000419975.1, ENST00000467460.6
    Conserved Domains (4) summary
    COG0457
    Location:266539
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:474502
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:511541
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:510571
    TPR_11; TPR repeat

RNA

  1. NR_146167.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007687, AC092939

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    179794958..180037009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006608.1XP_016862097.1  PEX5-related protein isoform X6

    UniProtKB/Swiss-Prot
    Q8IYB4
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  2. XM_024453592.1XP_024309360.1  PEX5-related protein isoform X3

    Conserved Domains (2) summary
    sd00006
    Location:486514
    TPR; TPR repeat [structural motif]
    cl26002
    Location:343573
    TPR_11; TPR repeat
  3. XM_024453593.1XP_024309361.1  PEX5-related protein isoform X5

    Conserved Domains (2) summary
    sd00006
    Location:429457
    TPR; TPR repeat [structural motif]
    cl26002
    Location:286516
    TPR_11; TPR repeat
  4. XM_024453590.1XP_024309358.1  PEX5-related protein isoform X1

    Conserved Domains (2) summary
    sd00006
    Location:551579
    TPR; TPR repeat [structural motif]
    cl26002
    Location:408638
    TPR_11; TPR repeat
  5. XM_024453591.1XP_024309359.1  PEX5-related protein isoform X2

    Conserved Domains (2) summary
    sd00006
    Location:520548
    TPR; TPR repeat [structural motif]
    cl26002
    Location:377607
    TPR_11; TPR repeat
  6. XM_017006607.1XP_016862096.1  PEX5-related protein isoform X6

    UniProtKB/Swiss-Prot
    Q8IYB4
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  7. XM_011512892.2XP_011511194.1  PEX5-related protein isoform X6

    See identical proteins and their annotated locations for XP_011511194.1

    UniProtKB/Swiss-Prot
    Q8IYB4
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  8. XM_011512891.2XP_011511193.1  PEX5-related protein isoform X6

    See identical proteins and their annotated locations for XP_011511193.1

    UniProtKB/Swiss-Prot
    Q8IYB4
    Conserved Domains (2) summary
    sd00006
    Location:282310
    TPR; TPR repeat [structural motif]
    cl26002
    Location:139369
    TPR_11; TPR repeat
  9. XM_011512888.2XP_011511190.1  PEX5-related protein isoform X4

    Conserved Domains (4) summary
    COG0457
    Location:236509
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:444472
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:481511
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:480541
    TPR_11; TPR repeat
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