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ACKR4 atypical chemokine receptor 4 [ Homo sapiens (human) ]

Gene ID: 51554, updated on 1-Aug-2020

Summary

Official Symbol
ACKR4provided by HGNC
Official Full Name
atypical chemokine receptor 4provided by HGNC
Primary source
HGNC:HGNC:1611
See related
Ensembl:ENSG00000129048 MIM:606065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
Expression
Broad expression in duodenum (RPKM 8.4), small intestine (RPKM 7.1) and 16 other tissues See more
Orthologs

Genomic context

See ACKR4 in Genome Data Viewer
Location:
3q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (132597270..132602644)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132316081..132321488)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NIP7 pseudogene 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene NPHP3-ACAD11 readthrough (NMD candidate) Neighboring gene acyl-CoA dehydrogenase family member 11 Neighboring gene heat shock protein family A (Hsp70) member pseudogene 19 Neighboring gene ubiquitin like modifier activating enzyme 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
NHGRI GWA Catalog
Genetic variation associated with circulating monocyte count in the eMERGE Network.
NHGRI GWA Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
early endosome IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
atypical chemokine receptor 4
Names
C-C CKR-11
C-C chemokine receptor type 11
CC chemokine receptor-like 1
chemocentryx chemokine receptor
chemokine (C-C motif) receptor-like 1
chemokine, cc motif, receptor-like protein 1
orphan seven-transmembrane receptor, chemokine related

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016557.4NP_057641.1  atypical chemokine receptor 4

    See identical proteins and their annotated locations for NP_057641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, as compared to variant 1. Both variants encode the some protein.
    Source sequence(s)
    AF110640, AK225927, BQ015927, DC419249
    Consensus CDS
    CCDS3075.1
    UniProtKB/Swiss-Prot
    Q9NPB9
    Related
    ENSP00000249887.2, ENST00000249887.3
    Conserved Domains (1) summary
    cd15176
    Location:42314
    7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_178445.2NP_848540.1  atypical chemokine receptor 4

    See identical proteins and their annotated locations for NP_848540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein.
    Source sequence(s)
    AC020632
    Consensus CDS
    CCDS3075.1
    UniProtKB/Swiss-Prot
    Q9NPB9
    Conserved Domains (1) summary
    cd15176
    Location:42314
    7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    132597270..132602644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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