Format

Send to:

Choose Destination

CINP cyclin dependent kinase 2 interacting protein [ Homo sapiens (human) ]

Gene ID: 51550, updated on 15-Apr-2019

Summary

Official Symbol
CINPprovided by HGNC
Official Full Name
cyclin dependent kinase 2 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:23789
See related
Ensembl:ENSG00000100865 MIM:613362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in testis (RPKM 6.8), brain (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See CINP in Genome Data Viewer
Location:
14q32.31
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (102348282..102362916, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102814619..102829253, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene zinc finger protein 839 Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene RNA, U6 small nuclear 244, pseudogene Neighboring gene ankyrin repeat domain 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 2-interacting protein
Names
CDK2-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320046.1NP_001306975.1  cyclin-dependent kinase 2-interacting protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL137229, DA167716
    Consensus CDS
    CCDS53915.1
    UniProtKB/Swiss-Prot
    Q9BW66
    Related
    ENSP00000442377.2, ENST00000541568.6
  2. NM_032630.3NP_116019.1  cyclin-dependent kinase 2-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_116019.1

    Status: REVIEWED

    Source sequence(s)
    BC000600, DA351468, EL951117
    Consensus CDS
    CCDS9972.1
    UniProtKB/Swiss-Prot
    Q9BW66
    UniProtKB/TrEMBL
    A0A024R6M9
    Related
    ENSP00000216756.6, ENST00000216756.11

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    102348282..102362916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177611.1: Suppressed sequence

    Description
    NM_001177611.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_001177612.1: Suppressed sequence

    Description
    NM_001177612.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center