U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SIRT7 sirtuin 7 [ Homo sapiens (human) ]

Gene ID: 51547, updated on 29-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
SIRT7provided by HGNC
Official Full Name
sirtuin 7provided by HGNC
Primary source
HGNC:HGNC:14935
See related
Ensembl:ENSG00000187531 MIM:606212; AllianceGenome:HGNC:14935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L7
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SIRT7 in Genome Data Viewer
Location:
17q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81911939..81918176, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82779099..82785336, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79869815..79876052, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79875237-79876133 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:79880785-79881984 Neighboring gene MAF bZIP transcription factor G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79882682-79883637

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation. Yi X, et al. Signal Transduct Target Ther, 2023 Mar 15. PMID 36918544, Free PMC Article
  2. Potent Activation of NAD(+)-Dependent Deacetylase Sirt7 by Nucleosome Binding. Kuznetsov VI, et al. ACS Chem Biol, 2022 Aug 19. PMID 35939806,
  3. A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease. Vigili de Kreutzenberg S, et al. Diabetologia, 2022 Sep. PMID 35708762, Free PMC Article
  4. Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis. Wu F, et al. Cancer Lett, 2022 Jan 28. PMID 34736960
  5. SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome. Yu HB, et al. Clin Sci (Lond), 2021 Jun 25. PMID 34128977

See all (124) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation.
    Title: SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation.
  2. SIRT7 silencing by miR-152-3p confers cell apoptosis and renal functional impairment induced by renal ischaemia/reperfusion injury.
    Title: SIRT7 silencing by miR-152-3p confers cell apoptosis and renal functional impairment induced by renal ischaemia/reperfusion injury.
  3. CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma.
    Title: CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma.
  4. USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.
    Title: USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.
  5. PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
    Title: PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
  6. SIRT7 Deficiency Protects against Abeta42-Induced Apoptosis through the Regulation of NOX4-Derived Reactive Oxygen Species Production in SH-SY5Y Cells.
    Title: SIRT7 Deficiency Protects against Aβ(42)-Induced Apoptosis through the Regulation of NOX4-Derived Reactive Oxygen Species Production in SH-SY5Y Cells.
  7. A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease.
    Title: A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease.
  8. Downregulation of LINC00886 facilitates epithelial-mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma.
    Title: Downregulation of LINC00886 facilitates epithelial-mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma.
  9. Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation.
    Title: Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation.
  10. The Role of Pentraxin-3, Fetuin-A and Sirtuin-7 in the Diagnosis of Prostate Cancer.
    Title: The Role of Pentraxin-3, Fetuin-A and Sirtuin-7 in the Diagnosis of Prostate Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (92)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC126840, MGC126842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD-dependent histone H3K18 deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables NAD-dependent histone H3K18 deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD-dependent histone H3K18 deacetylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glutaryllysine deglutarylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-propionyllysine depropionylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-succinyllysine desuccinylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair-dependent chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in R-loop processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression, epigenetic IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transposition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-lysine desuccinylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription involved in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deglutarylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein depropionylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus organizer region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
silent mating type information regulation 2, S.cerevisiae, homolog 7
sir2-related protein type 7
sirtuin type 7
NP_057622.1
XP_011521882.1
XP_047292184.1
XP_047292185.1
XP_047292186.1
XP_047292187.1
XP_054172376.1
XP_054172377.1
XP_054172378.1
XP_054172379.1
XP_054172380.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016538.3 → NP_057622.1  NAD-dependent protein deacetylase sirtuin-7

    See identical proteins and their annotated locations for NP_057622.1

    Status: REVIEWED

    Source sequence(s)
    BC017305, BC101791, BQ890203, CD579273
    Consensus CDS
    CCDS11792.1
    UniProtKB/Swiss-Prot
    Q9NRC8, Q9NUS6
    Related
    ENSP00000329466.6, ENST00000328666.11
    Conserved Domains (2) summary
    COG1196
    Location:7 → 94
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01410
    Location:100 → 314
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81911939..81918176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523580.2 → XP_011521882.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

    See identical proteins and their annotated locations for XP_011521882.1

    Conserved Domains (1) summary
    cd01410
    Location:78 → 279
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

  2. XM_047436229.1 → XP_047292185.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

  3. XM_047436228.1 → XP_047292184.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

  4. XM_047436231.1 → XP_047292187.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

  5. XM_047436230.1 → XP_047292186.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82779099..82785336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316401.1 → XP_054172376.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

  2. XM_054316403.1 → XP_054172378.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

  3. XM_054316402.1 → XP_054172377.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

  4. XM_054316405.1 → XP_054172380.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

  5. XM_054316404.1 → XP_054172379.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRC8.1 GenPept UniProtKB/Swiss-Prot:Q9NRC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous