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SIRT7 sirtuin 7 [ Homo sapiens (human) ]

Gene ID: 51547, updated on 8-Jul-2018
Official Symbol
SIRT7provided by HGNC
Official Full Name
sirtuin 7provided by HGNC
Primary source
HGNC:HGNC:14935
See related
Ensembl:ENSG00000187531 MIM:606212; Vega:OTTHUMG00000177957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L7
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues See more
Orthologs
See SIRT7 in Genome Data Viewer
Location:
17q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (81911939..81918182, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79869815..79876058, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene MAF bZIP transcription factor G Neighboring gene MAFG divergent transcript

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126840, MGC126842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K18 specific) IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 deacetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription involved in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus organizer region IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
silent mating type information regulation 2, S.cerevisiae, homolog 7
sir2-related protein type 7
sirtuin type 7
NP_057622.1
XP_011521882.1
XP_024306560.1
XP_024306561.1
XP_024306562.1
XP_024306563.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016538.2NP_057622.1  NAD-dependent protein deacetylase sirtuin-7

    See identical proteins and their annotated locations for NP_057622.1

    Status: REVIEWED

    Source sequence(s)
    BC017305, BC101791, BQ890203, CD579273
    Consensus CDS
    CCDS11792.1
    UniProtKB/Swiss-Prot
    Q9NRC8
    Related
    ENSP00000329466.6, OTTHUMP00000258199, ENST00000328666.10, OTTHUMT00000439961
    Conserved Domains (2) summary
    cd01410
    Location:100314
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    pfam07321
    Location:16101
    YscO; Type III secretion protein YscO

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    81911939..81918182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523580.1XP_011521882.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

    See identical proteins and their annotated locations for XP_011521882.1

    Conserved Domains (1) summary
    cd01410
    Location:78279
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
  2. XM_024450793.1XP_024306561.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

    Conserved Domains (2) summary
    cl00195
    Location:78321
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    cl26511
    Location:10109
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_024450792.1XP_024306560.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

    Conserved Domains (2) summary
    cd01410
    Location:100356
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
    pfam07321
    Location:16101
    YscO; Type III secretion protein YscO
  4. XM_024450794.1XP_024306562.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4

    Conserved Domains (1) summary
    cl00195
    Location:42285
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  5. XM_024450795.1XP_024306563.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

    Conserved Domains (1) summary
    cl00195
    Location:31274
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

RNA

  1. XR_430032.2 RNA Sequence

  2. XR_933936.1 RNA Sequence

    Related
    ENST00000536038.5
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