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SIRT7 sirtuin 7 [ Homo sapiens (human) ]

Gene ID: 51547, updated on 11-Jun-2021

Summary

Official Symbol
SIRT7provided by HGNC
Official Full Name
sirtuin 7provided by HGNC
Primary source
HGNC:HGNC:14935
See related
Ensembl:ENSG00000187531 MIM:606212
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L7
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues See more
Orthologs
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Genomic context

See SIRT7 in Genome Data Viewer
Location:
17q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81911939..81918176, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79869815..79876052, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene MAF bZIP transcription factor G Neighboring gene MAFG divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126840, MGC126842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent histone deacetylase activity (H3-K18 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K18 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-glutaryllysine deglutarylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-propionyllysine depropionylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-succinyllysine desuccinylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in R-loop disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4 deacetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in histone glutamine methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transposition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-lysine deglutarylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-lysine desuccinylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of rRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription involved in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deglutarylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein depropionylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of double-strand break repair via nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus organizer region IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-7
Names
NAD-dependent deacetylase sirtuin-7
NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7
regulatory protein SIR2 homolog 7
silent mating type information regulation 2, S.cerevisiae, homolog 7
sir2-related protein type 7
sirtuin type 7
NP_057622.1
XP_011521882.1
XP_024306560.1
XP_024306561.1
XP_024306562.1
XP_024306563.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016538.3NP_057622.1  NAD-dependent protein deacetylase sirtuin-7

    See identical proteins and their annotated locations for NP_057622.1

    Status: REVIEWED

    Source sequence(s)
    BC017305, BC101791, BQ890203, CD579273
    Consensus CDS
    CCDS11792.1
    UniProtKB/Swiss-Prot
    Q9NRC8
    Related
    ENSP00000329466.6, ENST00000328666.11
    Conserved Domains (2) summary
    COG1196
    Location:794
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01410
    Location:100314
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81911939..81918176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523580.1XP_011521882.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

    See identical proteins and their annotated locations for XP_011521882.1

    Conserved Domains (1) summary
    cd01410
    Location:78279
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
  2. XM_024450793.1XP_024306561.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

    Conserved Domains (2) summary
    cl00195
    Location:78321
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    cl26511
    Location:10109
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_024450792.1XP_024306560.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

    Conserved Domains (2) summary
    cd01410
    Location:100356
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
    pfam07321
    Location:16101
    YscO; Type III secretion protein YscO
  4. XM_024450794.1XP_024306562.1  NAD-dependent protein deacetylase sirtuin-7 isoform X4

    Conserved Domains (1) summary
    cl00195
    Location:42285
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  5. XM_024450795.1XP_024306563.1  NAD-dependent protein deacetylase sirtuin-7 isoform X5

    Conserved Domains (1) summary
    cl00195
    Location:31274
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

RNA

  1. XR_430032.2 RNA Sequence

  2. XR_933936.1 RNA Sequence

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