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TRMO tRNA methyltransferase O [ Homo sapiens (human) ]

Gene ID: 51531, updated on 12-Aug-2022

Summary

Official Symbol
TRMOprovided by HGNC
Official Full Name
tRNA methyltransferase Oprovided by HGNC
Primary source
HGNC:HGNC:30967
See related
Ensembl:ENSG00000136932 AllianceGenome:HGNC:30967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP1; HSPC219; C9orf156
Summary
Enables tRNA (adenine-N6-)-methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.2), lymph node (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

See TRMO in Genome Data Viewer
Location:
9q22.33
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (97896855..97922500, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110068792..110094437, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100659137..100684782, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1596 Neighboring gene VISTA enhancers hs1597 and hs1717 Neighboring gene hemogen Neighboring gene Sharpr-MPRA regulatory region 4249

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA m6t6A37 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA (adenine(37)-N6)-methyltransferase
Names
Nef (lentivirus myristoylated factor) associated protein 1
Nef associated protein 1
nef-associated protein 1
thioesterase NAP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330725.2NP_001317654.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/Swiss-Prot
    Q9BU70
    UniProtKB/TrEMBL
    Q5T114
    Conserved Domains (2) summary
    pfam18389
    Location:189257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:118
    UPF0066; Escherichia coli YaeB and related proteins
  2. NM_001371657.1NP_001358586.1  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL499604
    UniProtKB/Swiss-Prot
    Q9P0Q7
    Conserved Domains (2) summary
    pfam18389
    Location:335403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45164
    UPF0066; Uncharacterized protein family UPF0066
  3. NM_001371658.1NP_001358587.1  tRNA (adenine(37)-N6)-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (1) summary
    pfam01980
    Location:45164
    UPF0066; Uncharacterized protein family UPF0066
  4. NM_001371659.1NP_001358588.1  tRNA (adenine(37)-N6)-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (2) summary
    pfam18389
    Location:261329
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:290
    UPF0066; Uncharacterized protein family UPF0066
  5. NM_001371660.1NP_001358589.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    UniProtKB/TrEMBL
    Q5T114
    Conserved Domains (2) summary
    pfam18389
    Location:189257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:118
    UPF0066; Escherichia coli YaeB and related proteins
  6. NM_001371661.1NP_001358590.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    UniProtKB/TrEMBL
    Q5T114
    Related
    ENSP00000364259.1, ENST00000375118.1
    Conserved Domains (2) summary
    pfam18389
    Location:189257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:118
    UPF0066; Escherichia coli YaeB and related proteins
  7. NM_016481.5NP_057565.3  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_057565.3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS6730.1
    UniProtKB/Swiss-Prot
    Q9BU70, Q9P0Q7
    Related
    ENSP00000364260.3, ENST00000375119.8
    Conserved Domains (2) summary
    pfam18389
    Location:335403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45164
    UPF0066; Uncharacterized protein family UPF0066

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    97896855..97922500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518776.4XP_011517078.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

    Conserved Domains (1) summary
    cd09281
    Location:32159
    UPF0066; Escherichia coli YaeB and related proteins
  2. XM_047423465.1XP_047279421.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    110068792..110094437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)