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TRMO tRNA methyltransferase O [ Homo sapiens (human) ]

Gene ID: 51531, updated on 3-Mar-2026
Official Symbol
TRMOprovided by HGNC
Official Full Name
tRNA methyltransferase Oprovided by HGNC
Primary source
HGNC:HGNC:30967
See related
Ensembl:ENSG00000136932 AllianceGenome:HGNC:30967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP1; HSPC219; C9orf156
Summary
Enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thyroid (RPKM 2.2), lymph node (RPKM 1.5) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TRMO in Genome Data Viewer
Location:
9q22.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (97896855..97922500, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110061668..110094437, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100659137..100684782, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100465986-100467185 Neighboring gene keratin 18 pseudogene 13 Neighboring gene papillary thyroid carcinoma susceptibility candidate 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100520047-100521246 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:100534165-100534666 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:100534667-100535166 Neighboring gene VISTA enhancer hs1595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20103 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:100571176-100572375 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:100589760-100589981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100613975-100614476 Neighboring gene VISTA enhancer hs1596 Neighboring gene VISTA enhancers hs1597 and hs1717 Neighboring gene forkhead box E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28679 Neighboring gene hemogen Neighboring gene Sharpr-MPRA regulatory region 4249 Neighboring gene CRISPRi-validated cis-regulatory element chr9.1594 Neighboring gene uncharacterized LOC124902226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100745493-100746375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20110 Neighboring gene uncharacterized LOC124902225 Neighboring gene acidic nuclear phosphoprotein 32 family member B

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. Liu LX, et al. J Biol Chem, 1997 May 23. PMID 9153233
  2. FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Moreno LM, et al. Hum Mol Genet, 2009 Dec 15. PMID 19779022, Free PMC Article
  3. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. Takahashi M, et al. Hum Mol Genet, 2010 Jun 15. PMID 20350937
  4. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170, Free PMC Article
  5. Novel associations for hypothyroidism include known autoimmune risk loci. Eriksson N, et al. PLoS One, 2012. PMID 22493691, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tRNA (adenine(37)-N6)-methyltransferase
Names
Nef (lentivirus myristoylated factor) associated protein 1
Nef associated protein 1
nef-associated protein 1
thioesterase NAP1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330725.2 → NP_001317654.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/TrEMBL
    Q5T114
    Conserved Domains (2) summary
    pfam18389
    Location:189 → 257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:1 → 18
    UPF0066; Escherichia coli YaeB and related proteins

  2. NM_001371657.1 → NP_001358586.1  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS6730.1
    UniProtKB/Swiss-Prot
    Q5T113, Q86SK0, Q9BU70, Q9NXJ7, Q9P0Q7
    UniProtKB/TrEMBL
    A0ABB0MVG8
    Related
    ENSP00000534068.1, ENST00000864009.1
    Conserved Domains (2) summary
    pfam18389
    Location:335 → 403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45 → 164
    UPF0066; Uncharacterized protein family UPF0066

  3. NM_001371658.1 → NP_001358587.1  tRNA (adenine(37)-N6)-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    UniProtKB/TrEMBL
    A0ABB0MVG8
    Conserved Domains (1) summary
    pfam01980
    Location:45 → 164
    UPF0066; Uncharacterized protein family UPF0066

  4. NM_001371659.1 → NP_001358588.1  tRNA (adenine(37)-N6)-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (2) summary
    pfam18389
    Location:261 → 329
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:2 → 90
    UPF0066; Uncharacterized protein family UPF0066

  5. NM_001371660.1 → NP_001358589.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/TrEMBL
    Q5T114
    Conserved Domains (2) summary
    pfam18389
    Location:189 → 257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:1 → 18
    UPF0066; Escherichia coli YaeB and related proteins

  6. NM_001371661.1 → NP_001358590.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/TrEMBL
    Q5T114
    Related
    ENSP00000364259.1, ENST00000375118.1
    Conserved Domains (2) summary
    pfam18389
    Location:189 → 257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:1 → 18
    UPF0066; Escherichia coli YaeB and related proteins

  7. NM_016481.5 → NP_057565.3  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_057565.3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS6730.1
    UniProtKB/Swiss-Prot
    Q5T113, Q86SK0, Q9BU70, Q9NXJ7, Q9P0Q7
    UniProtKB/TrEMBL
    A0ABB0MVG8
    Related
    ENSP00000364260.3, ENST00000375119.8
    Conserved Domains (2) summary
    pfam18389
    Location:335 → 403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45 → 164
    UPF0066; Uncharacterized protein family UPF0066

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    97896855..97922500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518776.4 → XP_011517078.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0ABB0MVG8
    Related
    ENSP00000520829.1, ENST00000718443.1
    Conserved Domains (1) summary
    cd09281
    Location:32 → 159
    UPF0066; Escherichia coli YaeB and related proteins

  2. XM_047423465.1 → XP_047279421.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    110061668..110094437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363085.1 → XP_054219060.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0ABB0MVG8

  2. XM_054363086.1 → XP_054219061.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BU70.2 GenPept UniProtKB/Swiss-Prot:Q9BU70

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