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TRMO tRNA methyltransferase O [ Homo sapiens (human) ]

Gene ID: 51531, updated on 23-Nov-2021

Summary

Official Symbol
TRMOprovided by HGNC
Official Full Name
tRNA methyltransferase Oprovided by HGNC
Primary source
HGNC:HGNC:30967
See related
Ensembl:ENSG00000136932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP1; HSPC219; C9orf156
Expression
Ubiquitous expression in thyroid (RPKM 2.2), lymph node (RPKM 1.5) and 25 other tissues See more
Orthologs
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Genomic context

See TRMO in Genome Data Viewer
Location:
9q22.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (97896855..97922549, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100659137..100684782, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancers hs1597 and hs1717 Neighboring gene uncharacterized LOC112268051 Neighboring gene hemogen Neighboring gene CRISPRi-validated cis-regulatory element chr9.1594

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Novel associations for hypothyroidism include known autoimmune risk loci.
GeneReviews: Not available
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA (adenine-N6-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA (adenine-N6-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA (adenine(37)-N6)-methyltransferase
Names
Nef (lentivirus myristoylated factor) associated protein 1
Nef associated protein 1
nef-associated protein 1
thioesterase NAP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330725.2NP_001317654.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS83387.1
    UniProtKB/Swiss-Prot
    Q9BU70
    UniProtKB/TrEMBL
    Q5T114
    Conserved Domains (2) summary
    pfam18389
    Location:189257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:118
    UPF0066; Escherichia coli YaeB and related proteins
  2. NM_001371657.1NP_001358586.1  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (2) summary
    pfam18389
    Location:335403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45164
    UPF0066; Uncharacterized protein family UPF0066
  3. NM_001371658.1NP_001358587.1  tRNA (adenine(37)-N6)-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (1) summary
    pfam01980
    Location:45164
    UPF0066; Uncharacterized protein family UPF0066
  4. NM_001371659.1NP_001358588.1  tRNA (adenine(37)-N6)-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (2) summary
    pfam18389
    Location:261329
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:290
    UPF0066; Uncharacterized protein family UPF0066
  5. NM_001371660.1NP_001358589.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (2) summary
    pfam18389
    Location:189257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:118
    UPF0066; Escherichia coli YaeB and related proteins
  6. NM_001371661.1NP_001358590.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Conserved Domains (2) summary
    pfam18389
    Location:189257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:118
    UPF0066; Escherichia coli YaeB and related proteins
  7. NM_016481.5NP_057565.3  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_057565.3

    Status: VALIDATED

    Source sequence(s)
    AL499604
    Consensus CDS
    CCDS6730.1
    UniProtKB/Swiss-Prot
    Q9BU70
    Related
    ENSP00000364260.3, ENST00000375119.8
    Conserved Domains (2) summary
    pfam18389
    Location:335403
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:45164
    UPF0066; Uncharacterized protein family UPF0066

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    97896855..97922549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518776.3XP_011517078.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

    Conserved Domains (1) summary
    cd09281
    Location:32159
    UPF0066; Escherichia coli YaeB and related proteins
  2. XM_024447569.1XP_024303337.1  tRNA (adenine(37)-N6)-methyltransferase isoform X4

    Related
    ENSP00000364259.1, ENST00000375118.1
    Conserved Domains (2) summary
    pfam18389
    Location:189257
    TrmO_C; TrmO C-terminal domain
    cl00749
    Location:118
    UPF0066; Escherichia coli YaeB and related proteins
  3. XM_011518777.1XP_011517079.1  tRNA (adenine(37)-N6)-methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_011517079.1

    Conserved Domains (1) summary
    cl00749
    Location:3365
    UPF0066; Escherichia coli YaeB and related proteins

RNA

  1. XR_929808.3 RNA Sequence

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