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ZC3HC1 zinc finger C3HC-type containing 1 [ Homo sapiens (human) ]

Gene ID: 51530, updated on 5-Jul-2020

Summary

Official Symbol
ZC3HC1provided by HGNC
Official Full Name
zinc finger C3HC-type containing 1provided by HGNC
Primary source
HGNC:HGNC:29913
See related
Ensembl:ENSG00000091732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIPA; HSPC216
Summary
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in testis (RPKM 3.8), lymph node (RPKM 2.0) and 25 other tissues See more
Orthologs

Genomic context

See ZC3HC1 in Genome Data Viewer
Location:
7q32.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (130018286..130051451, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129658126..129691233, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 183 Neighboring gene ubiquitin conjugating enzyme E2 H Neighboring gene RNA, 5S ribosomal pseudogene 245 Neighboring gene kelch domain containing 10 Neighboring gene uncharacterized LOC100128325

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear-interacting partner of ALK
Names
hematopoietic stem/progenitor cell protein 216
nuclear interacting partner of anaplastic lymphoma kinase (ALK)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282190.1NP_001269119.1  nuclear-interacting partner of ALK isoform 2

    See identical proteins and their annotated locations for NP_001269119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, contains an alternate exon in the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC073320, AC087071, AF151050, AK001317, BC011551, BI830062
    Consensus CDS
    CCDS64767.1
    UniProtKB/Swiss-Prot
    Q86WB0
    Related
    ENSP00000309301.5, ENST00000311873.9
    Conserved Domains (2) summary
    pfam07967
    Location:52180
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:227317
    Rsm1; Rsm1-like
  2. NM_001282191.1NP_001269120.1  nuclear-interacting partner of ALK isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC073320, AC087071, AF151050, BC011551, BI830062, BM013594
    Consensus CDS
    CCDS75659.1
    UniProtKB/Swiss-Prot
    Q86WB0
    Related
    ENSP00000353933.5, ENST00000360708.9
    Conserved Domains (2) summary
    pfam07967
    Location:73201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248395
    Rsm1; Rsm1-like
  3. NM_001363701.1NP_001350630.1  nuclear-interacting partner of ALK isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC073320, AC087071
    Consensus CDS
    CCDS87546.1
    Related
    ENSP00000418533.1, ENST00000481503.5
    Conserved Domains (2) summary
    pfam07967
    Location:73201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:376423
    Rsm1; Rsm1-like
  4. NM_016478.5NP_057562.3  nuclear-interacting partner of ALK isoform 1

    See identical proteins and their annotated locations for NP_057562.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC073320, AC087071
    Consensus CDS
    CCDS34753.1
    UniProtKB/Swiss-Prot
    Q86WB0
    Related
    ENSP00000351052.4, ENST00000358303.9
    Conserved Domains (2) summary
    pfam07967
    Location:73201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248338
    Rsm1; Rsm1-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    130018286..130051451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446792.1XP_024302560.1  nuclear-interacting partner of ALK isoform X4

    Conserved Domains (3) summary
    pfam07967
    Location:188
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:135225
    Rsm1; Rsm1-like
    cl27109
    Location:206292
    Herpes_UL49_2; Herpesvirus UL49 tegument protein
  2. XM_005250403.3XP_005250460.1  nuclear-interacting partner of ALK isoform X5

    Conserved Domains (2) summary
    pfam07967
    Location:1477
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:124214
    Rsm1; Rsm1-like
  3. XM_011516288.3XP_011514590.1  nuclear-interacting partner of ALK isoform X2

    Conserved Domains (2) summary
    pfam07967
    Location:56134
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:181271
    Rsm1; Rsm1-like
  4. XM_011516289.2XP_011514591.1  nuclear-interacting partner of ALK isoform X3

    Conserved Domains (2) summary
    pfam07967
    Location:33111
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:158248
    Rsm1; Rsm1-like
  5. XM_011516290.2XP_011514592.1  nuclear-interacting partner of ALK isoform X6

    Conserved Domains (2) summary
    pfam07967
    Location:133
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:80170
    Rsm1; Rsm1-like
  6. XM_017012288.1XP_016867777.1  nuclear-interacting partner of ALK isoform X6

    Conserved Domains (2) summary
    pfam07967
    Location:133
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:80170
    Rsm1; Rsm1-like
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