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ANAPC11 anaphase promoting complex subunit 11 [ Homo sapiens (human) ]

Gene ID: 51529, updated on 5-Jul-2020

Summary

Official Symbol
ANAPC11provided by HGNC
Official Full Name
anaphase promoting complex subunit 11provided by HGNC
Primary source
HGNC:HGNC:14452
See related
Ensembl:ENSG00000141552 MIM:614534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC11; Apc11p; HSPC214
Expression
Ubiquitous expression in testis (RPKM 15.1), heart (RPKM 13.6) and 25 other tissues See more
Orthologs

Genomic context

See ANAPC11 in Genome Data Viewer
Location:
17q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81890790..81900533)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79849599..79858363)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene Aly/REF export factor Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene sirtuin 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NPB

Homology

Clone Names

  • MGC882

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cullin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
anaphase-promoting complex subunit 11
Names
APC11 anaphase promoting complex subunit 11 homolog
anaphase promoting complex subunit 11 (yeast APC11 homolog)
cyclosome subunit 11
hepatocellular carcinoma-associated RING finger protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002244.2NP_001002244.1  anaphase-promoting complex subunit 11 isoform 1

    See identical proteins and their annotated locations for NP_001002244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK308091, BC000607, HY067392
    Consensus CDS
    CCDS32769.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    UniProtKB/TrEMBL
    A0A024R8S1
    Related
    ENSP00000349957.3, ENST00000357385.7
    Conserved Domains (1) summary
    cl17238
    Location:151
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_001002245.2NP_001002245.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000461648.2, ENST00000571024.6
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. NM_001002246.2NP_001002246.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AF151048, AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000460064.2, ENST00000574924.6
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  4. NM_001002247.2NP_001002247.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000463640.1, ENST00000579978.5
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  5. NM_001002248.3NP_001002248.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AF151048, AK308091, BC000607, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000339695.5, ENST00000344877.9
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  6. NM_001002249.2NP_001002249.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001002249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC066308, BM845909
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000376181.3, ENST00000392376.7
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  7. NM_001289414.1NP_001276343.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AA356010, AK308091, AW965775
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000458143.1, ENST00000571570.5
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  8. NM_001289415.1NP_001276344.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC171898, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000458265.2, ENST00000572851.6
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  9. NM_001289416.1NP_001276345.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AK308091, BC066308, BM845909, BY796995
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000463598.1, ENST00000583839.1
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  10. NM_001289417.1NP_001276346.1  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001276346.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses an alternate splice site and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AC145207, AK308091, CA335305, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000464615.1, ENST00000578550.5
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  11. NM_001289420.1NP_001276349.1  anaphase-promoting complex subunit 11 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks an exon and contains two alternate exons in the 5' UTR, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC145207, AK308091, BC066308, BM762129, BM845909
    UniProtKB/Swiss-Prot
    Q9NYG5
    Conserved Domains (2) summary
    pfam12678
    Location:237
    zf-rbx1; RING-H2 zinc finger
    cl17238
    Location:151
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  12. NM_016476.11NP_057560.8  anaphase-promoting complex subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_057560.8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
    Source sequence(s)
    AF151048, AK308091, BC000607, BF512771, HY067392
    Consensus CDS
    CCDS11789.1
    UniProtKB/Swiss-Prot
    Q9NYG5
    Related
    ENSP00000459200.2, ENST00000571874.6
    Conserved Domains (2) summary
    cd16456
    Location:2376
    RING-H2_APC11; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:184
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81890790..81900533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001289418.1: Suppressed sequence

    Description
    NM_001289418.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  2. NM_001289419.1: Suppressed sequence

    Description
    NM_001289419.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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