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JKAMP JNK1/MAPK8 associated membrane protein [ Homo sapiens (human) ]

Gene ID: 51528, updated on 19-Sep-2020

Summary

Official Symbol
JKAMPprovided by HGNC
Official Full Name
JNK1/MAPK8 associated membrane proteinprovided by HGNC
Primary source
HGNC:HGNC:20184
See related
Ensembl:ENSG00000050130 MIM:611176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAMP; CDA06; HSPC213; HSPC327; C14orf100; C24orf100
Expression
Ubiquitous expression in testis (RPKM 16.2), adrenal (RPKM 14.0) and 25 other tissues See more
Orthologs

Genomic context

See JKAMP in Genome Data Viewer
Location:
14q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (59484495..59505410)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59951161..59972081)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dishevelled associated activator of morphogenesis 1 Neighboring gene G protein-coupled receptor 135 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene coiled-coil domain containing 175 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene uncharacterized LOC105370524 Neighboring gene leucine rich repeat containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
JNK1/MAPK8-associated membrane protein
Names
JNK-associated membrane protein
Jun N-terminal kinase 1-associated membrane protein
medulloblastoma antigen MU-MB-50.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098625.3NP_001092095.1  JNK1/MAPK8-associated membrane protein isoform 2

    See identical proteins and their annotated locations for NP_001092095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL121694, BC005198, BX161501, HY340214
    Consensus CDS
    CCDS45117.1
    UniProtKB/Swiss-Prot
    Q9P055
    Related
    ENSP00000389699.2, ENST00000425728.6
    Conserved Domains (1) summary
    pfam05571
    Location:3294
    DUF766; Protein of unknown function (DUF766)
  2. NM_001284201.2NP_001271130.1  JNK1/MAPK8-associated membrane protein isoform 3

    See identical proteins and their annotated locations for NP_001271130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK056145, AL121694, BX161501, DC381037, HY340214
    Consensus CDS
    CCDS61462.1
    UniProtKB/Swiss-Prot
    Q9P055
    UniProtKB/TrEMBL
    B3KPC2, G3V2M4
    Related
    ENSP00000450749.1, ENST00000554271.5
    Conserved Domains (1) summary
    pfam05571
    Location:23314
    DUF766; Protein of unknown function (DUF766)
  3. NM_001284202.2NP_001271131.1  JNK1/MAPK8-associated membrane protein isoform 4

    See identical proteins and their annotated locations for NP_001271131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL121694, BX161501, DC381037, HY340214
    Consensus CDS
    CCDS61463.1
    UniProtKB/Swiss-Prot
    Q9P055
    Related
    ENSP00000348351.5, ENST00000356057.9
    Conserved Domains (1) summary
    pfam05571
    Location:17308
    DUF766; Protein of unknown function (DUF766)
  4. NM_001284203.2NP_001271132.1  JNK1/MAPK8-associated membrane protein isoform 5

    See identical proteins and their annotated locations for NP_001271132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298209, AL121694, BX161501, DC381037, HY340214
    UniProtKB/Swiss-Prot
    Q9P055
    UniProtKB/TrEMBL
    A0A024R666
    Related
    ENST00000602482.5
    Conserved Domains (1) summary
    pfam05571
    Location:1237
    DUF766; Protein of unknown function (DUF766)
  5. NM_001284204.2NP_001271133.1  JNK1/MAPK8-associated membrane protein isoform 6

    See identical proteins and their annotated locations for NP_001271133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AF212245, AL121694, BU928810, BX161501, HY340214
    UniProtKB/Swiss-Prot
    Q9P055
    UniProtKB/TrEMBL
    A0A087WVY6
    Conserved Domains (1) summary
    pfam05571
    Location:9213
    DUF766; Protein of unknown function (DUF766)
  6. NM_016475.5NP_057559.2  JNK1/MAPK8-associated membrane protein isoform 1

    See identical proteins and their annotated locations for NP_057559.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL121694, AL136696, BX161501, DC381037, HY340214
    Consensus CDS
    CCDS45116.1
    UniProtKB/Swiss-Prot
    Q9P055
    Related
    ENSP00000479775.2, ENST00000616435.5
    Conserved Domains (1) summary
    pfam05571
    Location:9300
    DUF766; Protein of unknown function (DUF766)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    59484495..59505410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720171.4XP_006720234.1  JNK1/MAPK8-associated membrane protein isoform X2

    Related
    ENSP00000450813.1, ENST00000554795.1
    Conserved Domains (1) summary
    pfam05571
    Location:23227
    DUF766; Protein of unknown function (DUF766)
  2. XM_024449627.1XP_024305395.1  JNK1/MAPK8-associated membrane protein isoform X1

    Conserved Domains (1) summary
    pfam05571
    Location:23314
    DUF766; Protein of unknown function (DUF766)
  3. XM_017021366.1XP_016876855.1  JNK1/MAPK8-associated membrane protein isoform X3

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