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GSKIP GSK3B interacting protein [ Homo sapiens (human) ]

Gene ID: 51527, updated on 11-Sep-2019

Summary

Official Symbol
GSKIPprovided by HGNC
Official Full Name
GSK3B interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:20343
See related
Ensembl:ENSG00000100744 MIM:616605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC210; C14orf129
Summary
This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Expression
Broad expression in colon (RPKM 25.5), small intestine (RPKM 20.7) and 24 other tissues See more
Orthologs

Genomic context

See GSKIP in Genome Data Viewer
Location:
14q32.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (96363452..96387290)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96829789..96853627)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene bradykinin receptor B1 Neighboring gene autophagy related 2B Neighboring gene Sharpr-MPRA regulatory region 11883 Neighboring gene RNA, U2 small nuclear 33, pseudogene Neighboring gene translation machinery-associated protein 7-like Neighboring gene adenylate kinase 7 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4945

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GSK3B-interacting protein
Names
GSK3-beta interaction protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271904.1NP_001258833.1  GSK3B-interacting protein

    See identical proteins and their annotated locations for NP_001258833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK094654, AL359240, W04717
    Consensus CDS
    CCDS32153.1
    UniProtKB/Swiss-Prot
    Q9P0R6
    UniProtKB/TrEMBL
    A0A024R6P6
    Related
    ENSP00000451188.1, ENST00000556095.5
    Conserved Domains (1) summary
    pfam05303
    Location:33133
    DUF727; Protein of unknown function (DUF727)
  2. NM_001271905.1NP_001258834.1  GSK3B-interacting protein

    See identical proteins and their annotated locations for NP_001258834.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK094654, AL359240, DA488110, HY051680, W04717
    Consensus CDS
    CCDS32153.1
    UniProtKB/Swiss-Prot
    Q9P0R6
    UniProtKB/TrEMBL
    A0A024R6P6
    Related
    ENSP00000451384.1, ENST00000554182.5
    Conserved Domains (1) summary
    pfam05303
    Location:33133
    DUF727; Protein of unknown function (DUF727)
  3. NM_001271906.1NP_001258835.1  GSK3B-interacting protein

    See identical proteins and their annotated locations for NP_001258835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK094654, AL359240, HY051680, HY108584, W04717
    Consensus CDS
    CCDS32153.1
    UniProtKB/Swiss-Prot
    Q9P0R6
    UniProtKB/TrEMBL
    A0A024R6P6
    Related
    ENSP00000412315.1, ENST00000438650.5
    Conserved Domains (1) summary
    pfam05303
    Location:33133
    DUF727; Protein of unknown function (DUF727)
  4. NM_016472.5NP_057556.2  GSK3B-interacting protein

    See identical proteins and their annotated locations for NP_057556.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL359240
    Consensus CDS
    CCDS32153.1
    UniProtKB/Swiss-Prot
    Q9P0R6
    UniProtKB/TrEMBL
    A0A024R6P6
    Related
    ENSP00000450420.1, ENST00000555181.6
    Conserved Domains (1) summary
    pfam05303
    Location:33133
    DUF727; Protein of unknown function (DUF727)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    96363452..96387290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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