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ATF3 activating transcription factor 3 [ Bos taurus (domestic cattle) ]

Gene ID: 515266, updated on 5-Sep-2025
Official Symbol
ATF3provided by VGNC
Official Full Name
activating transcription factor 3provided by VGNC
Primary source
VGNC:VGNC:26241
See related
BGD:BT11469
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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Try the new Transcripts and proteins table
See ATF3 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (70924499..70937427, complement)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene golgi associated RAB2 interactor family member 4 Neighboring gene uncharacterized LOC101906463 Neighboring gene uncharacterized LOC112441863

Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. ATF3 expression in the corpus luteum: possible role in luteal regression. Mao D, et al. Mol Endocrinol, 2013 Dec. PMID 24196350, Free PMC Article
  2. Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide. Chen SC, et al. Atherosclerosis, 2008 Dec. PMID 18377912
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATF3 appears to affect gonadotropin-stimulated progesterone secretion at a step or steps downstream of PKA signaling and before cholesterol conversion to progesterone.
    Title: ATF3 expression in the corpus luteum: possible role in luteal regression.
  2. ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK pathway in endothelial cells
    Title: Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC137608

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cyclic AMP-dependent transcription factor ATF-3
Names
cAMP-dependent transcription factor ATF-3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046193.2 → NP_001039658.1  cyclic AMP-dependent transcription factor ATF-3

    See identical proteins and their annotated locations for NP_001039658.1

    Status: PROVISIONAL

    Source sequence(s)
    BC112629
    UniProtKB/Swiss-Prot
    Q2KII1
    Conserved Domains (1) summary
    cd14722
    Location:96 → 149
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    70924499..70937427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059875376.1 → XP_059731359.1  cyclic AMP-dependent transcription factor ATF-3 isoform X2

    UniProtKB/Swiss-Prot
    Q2KII1

  2. XM_010813555.4 → XP_010811857.1  cyclic AMP-dependent transcription factor ATF-3 isoform X2

    See identical proteins and their annotated locations for XP_010811857.1

    UniProtKB/Swiss-Prot
    Q2KII1
    Conserved Domains (1) summary
    cd14722
    Location:96 → 149
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

  3. XM_059875375.1 → XP_059731358.1  cyclic AMP-dependent transcription factor ATF-3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KII1.1 GenPept UniProtKB/Swiss-Prot:Q2KII1

Gene LinkOut

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Molecular Biology Databases
Research Materials