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CXXC5 CXXC finger protein 5 [ Homo sapiens (human) ]

Gene ID: 51523, updated on 16-Sep-2019

Summary

Official Symbol
CXXC5provided by HGNC
Official Full Name
CXXC finger protein 5provided by HGNC
Primary source
HGNC:HGNC:26943
See related
Ensembl:ENSG00000171604 MIM:612752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CF5; WID; RINF; HSPC195
Summary
The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues See more
Orthologs

Genomic context

See CXXC5 in Genome Data Viewer
Location:
5q31.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (139647299..139683885)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139028301..139063467)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 D2 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 15 Neighboring gene H3 histone pseudogene 25 Neighboring gene CXXC5 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 236, pseudogene Neighboring gene pleckstrin and Sec7 domain containing 2 Neighboring gene PSD2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CXXC-type zinc finger protein 5
Names
CXXC finger 5 protein
WT1-induced Inhibitor of Dishevelled
putative MAPK-activating protein PM08
putative NF-kappa-B-activating protein 102
retinoid-inducible nuclear factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317199.2NP_001304128.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All of the variants encode the same protein.
    Source sequence(s)
    AK024338, BC006428, DA291558
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  2. NM_001317200.2NP_001304129.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AK001782, BC006428
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Related
    ENSP00000427379.1, ENST00000511048.1
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  3. NM_001317201.1NP_001304130.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BU187119, DA705695
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  4. NM_001317202.1NP_001304131.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BU187119, DA264868
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  5. NM_001317203.2NP_001304132.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC113361, BC006428, BI763590, DA031665
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  6. NM_001317204.2NP_001304133.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AC113361, BC006428, DA031665
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  7. NM_001317205.1NP_001304134.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BU187119, DA170918
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  8. NM_001317206.1NP_001304135.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BU187119, CB140368, HY181287
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  9. NM_001317207.1NP_001304136.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BU187119, CB140368
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  10. NM_001317208.2NP_001304137.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, DB458723
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  11. NM_001317209.2NP_001304138.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BI460400, HY012710
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  12. NM_001317210.2NP_001304139.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BI460400, HY043636
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  13. NM_001317211.2NP_001304140.1  CXXC-type zinc finger protein 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    BC006428, BI460400, HY015270
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain
  14. NM_016463.9NP_057547.5  CXXC-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_057547.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
    Source sequence(s)
    AK024338, BC006428
    Consensus CDS
    CCDS43370.1
    UniProtKB/Swiss-Prot
    Q7LFL8
    Related
    ENSP00000302543.3, ENST00000302517.8
    Conserved Domains (1) summary
    pfam02008
    Location:255296
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    139647299..139683885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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