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NCKIPSD NCK interacting protein with SH3 domain [ Homo sapiens (human) ]

Gene ID: 51517, updated on 12-Aug-2018

Summary

Official Symbol
NCKIPSDprovided by HGNC
Official Full Name
NCK interacting protein with SH3 domainprovided by HGNC
Primary source
HGNC:HGNC:15486
See related
Ensembl:ENSG00000213672 MIM:606671; Vega:OTTHUMG00000133542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIP; DIP1; ORF1; WISH; VIP54; AF3P21; SPIN90; WASLBP
Summary
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in ovary (RPKM 9.3), brain (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See NCKIPSD in Genome Data Viewer
Location:
3p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (48663814..48685941, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48700419..48723366, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 6 Neighboring gene microRNA 6824 Neighboring gene cadherin EGF LAG seven-pass G-type receptor 3 Neighboring gene microRNA 4793 Neighboring gene long intergenic non-protein coding RNA 2585 Neighboring gene inositol hexakisphosphate kinase 2 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NCK interacting protein with SH3 domain (NCKIPSD) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
    Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemWASP and WAVE proteins belong to the Wiskott-Aldrich Syndrome protein family, with recessive mutations in the founding member WASP being responsible for the X-linked recessive immunodeficieny known a...
  • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
    Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal protein binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
NLS-bearing protein import into nucleus TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NCK-interacting protein with SH3 domain
Names
54 kDa VacA-interacting protein
54 kDa vimentin-interacting protein
90 kDa SH3 protein interacting with Nck
SH3 adapter protein SPIN90
SH3 protein interacting with Nck, 90 kDa
WASP-interacting SH3-domain protein
dia interacting protein
dia-interacting protein 1
diaphanous protein interacting protein
wiskott-Aldrich syndrome protein-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016453.3NP_057537.1  NCK-interacting protein with SH3 domain isoform 1

    See identical proteins and their annotated locations for NP_057537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF303581, AI863106, HY010884, HY050918
    Consensus CDS
    CCDS2776.1
    UniProtKB/Swiss-Prot
    Q9NZQ3
    Related
    ENSP00000294129.2, OTTHUMP00000164823, ENST00000294129.6, OTTHUMT00000257520
    Conserved Domains (2) summary
    cd11849
    Location:154
    SH3_SPIN90; Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
    pfam09431
    Location:570683
    DUF2013; Protein of unknown function (DUF2013)
  2. NM_184231.2NP_909119.1  NCK-interacting protein with SH3 domain isoform 2

    See identical proteins and their annotated locations for NP_909119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AI863106, BC016052, HY010884, HY050918
    Consensus CDS
    CCDS46827.1
    UniProtKB/Swiss-Prot
    Q9NZQ3
    Related
    ENSP00000389059.2, OTTHUMP00000210186, ENST00000416649.6, OTTHUMT00000344817
    Conserved Domains (2) summary
    cd11849
    Location:154
    SH3_SPIN90; Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)
    pfam09431
    Location:563676
    DUF2013; Protein of unknown function (DUF2013)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    48663814..48685941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006595.1XP_016862084.1  NCK-interacting protein with SH3 domain isoform X2

  2. XM_017006594.1XP_016862083.1  NCK-interacting protein with SH3 domain isoform X1

  3. XM_017006596.1XP_016862085.1  NCK-interacting protein with SH3 domain isoform X3

  4. XM_017006598.1XP_016862087.1  NCK-interacting protein with SH3 domain isoform X4

  5. XM_017006597.1XP_016862086.1  NCK-interacting protein with SH3 domain isoform X3

  6. XM_017006599.1XP_016862088.1  NCK-interacting protein with SH3 domain isoform X5

    Conserved Domains (1) summary
    pfam09431
    Location:492605
    DUF2013; Protein of unknown function (DUF2013)
  7. XM_017006600.1XP_016862089.1  NCK-interacting protein with SH3 domain isoform X6

    Conserved Domains (1) summary
    pfam09431
    Location:485598
    DUF2013; Protein of unknown function (DUF2013)

RNA

  1. XR_002959541.1 RNA Sequence

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