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GTSE1 G2 and S-phase expressed 1 [ Homo sapiens (human) ]

Gene ID: 51512, updated on 9-Feb-2020

Summary

Official Symbol
GTSE1provided by HGNC
Official Full Name
G2 and S-phase expressed 1provided by HGNC
Primary source
HGNC:HGNC:13698
See related
Ensembl:ENSG00000075218 MIM:607477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B99
Summary
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.8), lymph node (RPKM 2.7) and 15 other tissues See more
Orthologs

Genomic context

See GTSE1 in Genome Data Viewer
Location:
22q13.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (46295143..46333699)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46692638..46729596)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene polycystin family receptor for egg jelly Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene GTSE1 divergent transcript Neighboring gene tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase Neighboring gene cadherin EGF LAG seven-pass G-type receptor 1 Neighboring gene family with sequence similarity 136 member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G2 and S phase-expressed protein 1
Names
G-2 and S-phase expressed 1
protein B99 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016426.7NP_057510.5  G2 and S phase-expressed protein 1

    Status: REVIEWED

    Source sequence(s)
    AL031588, Z93024
    Consensus CDS
    CCDS14074.2
    Related
    ENSP00000415430.1, ENST00000454366.2
    Conserved Domains (2) summary
    pfam15259
    Location:28171
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:169662
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    46295143..46333699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261627.4XP_005261684.1  G2 and S phase-expressed protein 1 isoform X1

    Conserved Domains (2) summary
    pfam15259
    Location:28171
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:169662
    Atrophin-1; Atrophin-1 family
  2. XM_017028816.2XP_016884305.1  G2 and S phase-expressed protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15259
    Location:28171
    GTSE1_N; G-2 and S-phase expressed 1
  3. XM_011530213.3XP_011528515.1  G2 and S phase-expressed protein 1 isoform X3

    Conserved Domains (1) summary
    pfam15259
    Location:28171
    GTSE1_N; G-2 and S-phase expressed 1
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