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GTSE1 G2 and S-phase expressed 1 [ Homo sapiens (human) ]

Gene ID: 51512, updated on 23-Sep-2022

Summary

Official Symbol
GTSE1provided by HGNC
Official Full Name
G2 and S-phase expressed 1provided by HGNC
Primary source
HGNC:HGNC:13698
See related
Ensembl:ENSG00000075218 MIM:607477; AllianceGenome:HGNC:13698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B99
Summary
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.8), lymph node (RPKM 2.7) and 15 other tissues See more
Orthologs
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Genomic context

See GTSE1 in Genome Data Viewer
Location:
22q13.31
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (46296870..46330810)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (46781567..46815510)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46692767..46726707)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene GTSE1 divergent transcript Neighboring gene tRNA mitochondrial 2-thiouridylase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:46772879-46774078 Neighboring gene cadherin EGF LAG seven-pass G-type receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G2 and S phase-expressed protein 1
Names
G-2 and S-phase expressed 1
Lnc_bc060912
protein B99 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016426.7NP_057510.5  G2 and S phase-expressed protein 1

    Status: REVIEWED

    Source sequence(s)
    AL031588, Z93024
    Consensus CDS
    CCDS14074.2
    Related
    ENSP00000415430.1, ENST00000454366.2
    Conserved Domains (2) summary
    pfam15259
    Location:28171
    GTSE1_N; G-2 and S-phase expressed 1
    cl26464
    Location:169662
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    46296870..46330810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441391.1XP_047297347.1  G2 and S phase-expressed protein 1 isoform X1

  2. XM_047441392.1XP_047297348.1  G2 and S phase-expressed protein 1 isoform X2

RNA

  1. XR_007067974.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    46781567..46815510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)