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TRMT112 tRNA methyltransferase subunit 11-2 [ Homo sapiens (human) ]

Gene ID: 51504, updated on 20-Dec-2019

Summary

Official Symbol
TRMT112provided by HGNC
Official Full Name
tRNA methyltransferase subunit 11-2provided by HGNC
Primary source
HGNC:HGNC:26940
See related
Ensembl:ENSG00000173113 MIM:618630
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2
Expression
Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues See more
Orthologs

Genomic context

See TRMT112 in Genome Data Viewer
Location:
11q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64316460..64318596, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64084163..64085455, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KCNK4-TEX40 readthrough Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene estrogen related receptor alpha Neighboring gene peroxiredoxin 5 Neighboring gene uncharacterized LOC102723878 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3041 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of tRNA methyltransferase 11-2 homolog (TRMT112) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to rRNA (guanine) methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
methylation TAS
Traceable Author Statement
more info
 
peptidyl-glutamine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-glutamine methylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA (guanine-N7)-methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA (guanine-N7)-methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA methylation TAS
Traceable Author Statement
more info
 
tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
multifunctional methyltransferase subunit TRM112-like protein
Names
TRM112-like protein
tRNA methyltransferase 11-2 homolog
tRNA methyltransferase 112 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286082.2NP_001273011.1  multifunctional methyltransferase subunit TRM112-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS66113.1
    UniProtKB/Swiss-Prot
    Q9UI30
    Related
    ENSP00000309433.2, ENST00000308774.6
    Conserved Domains (1) summary
    pfam03966
    Location:81107
    Trm112p; Trm112p-like protein
  2. NM_001286084.2NP_001273013.1  multifunctional methyltransferase subunit TRM112-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS73312.1
    UniProtKB/TrEMBL
    F5GX77
    Related
    ENSP00000440437.1, ENST00000539854.1
  3. NM_001372071.1NP_001359000.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
  4. NM_001372072.1NP_001359001.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
  5. NM_016404.3NP_057488.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    See identical proteins and their annotated locations for NP_057488.1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS8068.1
    UniProtKB/Swiss-Prot
    Q9UI30
    UniProtKB/TrEMBL
    A0A024R565
    Related
    ENSP00000438349.1, ENST00000544844.5
    Conserved Domains (1) summary
    pfam03966
    Location:86112
    Trm112p; Trm112p-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64316460..64318596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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