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TRMT112 tRNA methyltransferase activator subunit 11-2 [ Homo sapiens (human) ]

Gene ID: 51504, updated on 25-Jan-2022

Summary

Official Symbol
TRMT112provided by HGNC
Official Full Name
tRNA methyltransferase activator subunit 11-2provided by HGNC
Primary source
HGNC:HGNC:26940
See related
Ensembl:ENSG00000173113 MIM:618630; AllianceGenome:HGNC:26940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2
Summary
Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues See more
Orthologs
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Genomic context

See TRMT112 in Genome Data Viewer
Location:
11q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64316460..64318596, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64083932..64086068, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KCNK4-TEX40 readthrough Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene estrogen related receptor alpha Neighboring gene peroxiredoxin 5 Neighboring gene uncharacterized LOC102723878 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3041 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of tRNA methyltransferase 11-2 homolog (TRMT112) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in histone lysine methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-glutamine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-glutamine methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA (guanine-N7)-methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA (guanine-N7)-methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
multifunctional methyltransferase subunit TRM112-like protein
Names
TRM112-like protein
tRNA methyltransferase 11-2 homolog
tRNA methyltransferase 112 homolog
tRNA methyltransferase subunit 11-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286082.2NP_001273011.1  multifunctional methyltransferase subunit TRM112-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS66113.1
    UniProtKB/Swiss-Prot
    Q9UI30
    Related
    ENSP00000309433.2, ENST00000308774.6
    Conserved Domains (1) summary
    pfam03966
    Location:81107
    Trm112p; Trm112p-like protein
  2. NM_001286084.2NP_001273013.1  multifunctional methyltransferase subunit TRM112-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS73312.1
    UniProtKB/TrEMBL
    F5GX77
  3. NM_001372071.1NP_001359000.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Conserved Domains (1) summary
    cd21089
    Location:2118
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins
  4. NM_001372072.1NP_001359001.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Conserved Domains (1) summary
    cd21089
    Location:2118
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins
  5. NM_016404.3NP_057488.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    See identical proteins and their annotated locations for NP_057488.1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS8068.1
    UniProtKB/Swiss-Prot
    Q9UI30
    UniProtKB/TrEMBL
    A0A024R565
    Related
    ENSP00000438349.2, ENST00000544844.6
    Conserved Domains (1) summary
    cd21089
    Location:2118
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64316460..64318596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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