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ATP5PB ATP synthase peripheral stalk-membrane subunit b [ Homo sapiens (human) ]

Gene ID: 515, updated on 6-Nov-2022


Official Symbol
ATP5PBprovided by HGNC
Official Full Name
ATP synthase peripheral stalk-membrane subunit bprovided by HGNC
Primary source
See related
Ensembl:ENSG00000116459 MIM:603270; AllianceGenome:HGNC:840
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]
Ubiquitous expression in heart (RPKM 107.3), colon (RPKM 76.0) and 25 other tissues See more
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Genomic context

See ATP5PB in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (111449464..111462773)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111464148..111477456)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111992086..112005395)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene UBE2F pseudogene 3 Neighboring gene WD repeat domain 77 Neighboring gene chromosome 1 open reading frame 162 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene RNA, U6 small nuclear 792, pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ATP synthase, mitochondrial Fo complex, subunit B1 (ATP5F1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 (ATP5F1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC24431

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
ATP synthase F(0) complex subunit B1, mitochondrial
ATP synthase B chain, mitochondrial
ATP synthase proton-transporting mitochondrial F(0) complex subunit B1
ATP synthase subunit b, mitochondrial
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b
ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1
ATPase subunit b
H+-ATP synthase subunit b
cell proliferation-inducing protein 47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001688.5NP_001679.2  ATP synthase F(0) complex subunit B1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001679.2

    Status: REVIEWED

    Source sequence(s)
    AI754631, AL390195, AW778751, BF237506
    Consensus CDS
    P24539, Q9BRU8
    A0A024R0E1, Q08ET0
    ENSP00000358737.3, ENST00000369722.8
    Conserved Domains (1) summary
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060925.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002014.1: Suppressed sequence

    NM_001002014.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  2. NM_001002015.1: Suppressed sequence

    NM_001002015.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.