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ATP5PB ATP synthase peripheral stalk-membrane subunit b [ Homo sapiens (human) ]

Gene ID: 515, updated on 7-Oct-2018

Summary

Official Symbol
ATP5PBprovided by HGNC
Official Full Name
ATP synthase peripheral stalk-membrane subunit bprovided by HGNC
Primary source
HGNC:HGNC:840
See related
Ensembl:ENSG00000116459 MIM:603270; Vega:OTTHUMG00000011745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG47; ATP5F1
Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 107.3), colon (RPKM 76.0) and 25 other tissues See more
Orthologs

Genomic context

See ATP5PB in Genome Data Viewer
Location:
1p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (111449121..111461918)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111991467..112004540)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene oviductal glycoprotein 1 Neighboring gene UBE2F pseudogene 3 Neighboring gene WD repeat domain 77 Neighboring gene chromosome 1 open reading frame 162 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene RNA, U6 small nuclear 792, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ATP synthase, mitochondrial Fo complex, subunit B1 (ATP5F1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 (ATP5F1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24431

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
ATP hydrolysis coupled cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ATP synthesis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IC
Inferred by Curator
more info
PubMed 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
membrane HDA PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial matrix NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
ATP synthase F(0) complex subunit B1, mitochondrial
Names
ATP synthase B chain, mitochondrial
ATP synthase proton-transporting mitochondrial F(0) complex subunit B1
ATP synthase subunit b, mitochondrial
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1
ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1
ATPase subunit b
H+-ATP synthase subunit b
cell proliferation-inducing protein 47

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001688.4NP_001679.2  ATP synthase F(0) complex subunit B1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001679.2

    Status: REVIEWED

    Source sequence(s)
    AI754631, AL390195, AW778751, BF237506
    Consensus CDS
    CCDS836.1
    UniProtKB/Swiss-Prot
    P24539
    UniProtKB/TrEMBL
    Q08ET0
    Related
    ENSP00000358737.3, OTTHUMP00000013469, ENST00000369722.7, OTTHUMT00000032455
    Conserved Domains (1) summary
    pfam05405
    Location:83244
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    111449121..111461918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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