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TRIAP1 TP53 regulated inhibitor of apoptosis 1 [ Homo sapiens (human) ]

Gene ID: 51499, updated on 8-Aug-2021

Summary

Official Symbol
TRIAP1provided by HGNC
Official Full Name
TP53 regulated inhibitor of apoptosis 1provided by HGNC
Primary source
HGNC:HGNC:26937
See related
Ensembl:ENSG00000170855 MIM:614943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WF-1; MDM35; P53CSV; HSPC132
Expression
Ubiquitous expression in colon (RPKM 17.2), liver (RPKM 15.9) and 25 other tissues See more
Orthologs
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Genomic context

See TRIAP1 in Genome Data Viewer
Location:
12q24.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120443964..120446384, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120881767..120884187, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene 25 Neighboring gene Sharpr-MPRA regulatory region 3971 Neighboring gene cytochrome c oxidase subunit 6A1 Neighboring gene ribosomal protein L31 pseudogene 52 Neighboring gene glutamyl-tRNA amidotransferase subunit C Neighboring gene serine and arginine rich splicing factor 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to phosphatidic acid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phospholipid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of membrane lipid distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TP53-regulated inhibitor of apoptosis 1
Names
mitochondrial distribution and morphology 35 homolog
p53-inducible cell-survival factor
protein 15E1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016399.3NP_057483.1  TP53-regulated inhibitor of apoptosis 1

    See identical proteins and their annotated locations for NP_057483.1

    Status: VALIDATED

    Source sequence(s)
    CB141335, U75688
    Consensus CDS
    CCDS9198.1
    UniProtKB/Swiss-Prot
    O43715
    Related
    ENSP00000449795.1, ENST00000546954.2
    Conserved Domains (1) summary
    pfam05254
    Location:268
    UPF0203; Uncharacterized protein family (UPF0203)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120443964..120446384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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