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NELFCD negative elongation factor complex member C/D [ Homo sapiens (human) ]

Gene ID: 51497, updated on 3-May-2020

Summary

Official Symbol
NELFCDprovided by HGNC
Official Full Name
negative elongation factor complex member C/Dprovided by HGNC
Primary source
HGNC:HGNC:15934
See related
Ensembl:ENSG00000101158 MIM:605297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TH1; TH1L; NELF-C; NELF-D; HSPC130
Summary
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 29.3), thyroid (RPKM 23.1) and 25 other tissues See more
Orthologs

Genomic context

See NELFCD in Genome Data Viewer
Location:
20q13.32
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (58981252..58995133)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (57556263..57570400)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene GNAS complex locus Neighboring gene uncharacterized LOC101927932 Neighboring gene uncharacterized LOC107985382 Neighboring gene small integral membrane protein 30-like Neighboring gene cathepsin Z Neighboring gene tubulin beta 1 class VI Neighboring gene ATP synthase F1 subunit epsilon

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat NELF represses HIV-1 transcription by pausing the RNA polymerase II complex PubMed
tat NELF associates with HIV-1 Tat as part of the HIV-1 transcription elongation complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
NELF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NELF complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
negative elongation factor C/D
Names
NELF-C/D
TH1 drosophila homolog
TH1-like protein
negative elongation factor proteins C and D
trihydrophobin 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198976.4NP_945327.3  negative elongation factor C/D

    Status: REVIEWED

    Source sequence(s)
    AK293410, BQ022435
    Consensus CDS
    CCDS13473.2
    Related
    ENSP00000499018.1, ENST00000652272.2
    Conserved Domains (1) summary
    pfam04858
    Location:2578
    TH1; TH1 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    58981252..58995133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_244142.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016397.2: Suppressed sequence

    Description
    NM_016397.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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