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HACD3 3-hydroxyacyl-CoA dehydratase 3 [ Homo sapiens (human) ]

Gene ID: 51495, updated on 7-Jun-2020

Summary

Official Symbol
HACD3provided by HGNC
Official Full Name
3-hydroxyacyl-CoA dehydratase 3provided by HGNC
Primary source
HGNC:HGNC:24175
See related
Ensembl:ENSG00000074696 MIM:615940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIND1; B-IND1; HSPC121; PTPLAD1
Expression
Ubiquitous expression in brain (RPKM 49.9), adrenal (RPKM 46.4) and 25 other tissues See more
Orthologs

Genomic context

See HACD3 in Genome Data Viewer
Location:
15q22.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65530463..65578355)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65822804..65870693)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily DCC subclass member 4 Neighboring gene dipeptidyl peptidase 8 Neighboring gene RNA, U6 small nuclear 19, pseudogene Neighboring gene integrator complex subunit 14 Neighboring gene uncharacterized LOC102723464 Neighboring gene solute carrier family 24 member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify protein tyrosine phosphatase-like A domain containing 1 (PTPLAD1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-hydroxy-arachidoyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxy-behenoyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxy-lignoceroyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxyacyl-CoA dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3-hydroxyacyl-CoA dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
very-long-chain 3-hydroxyacyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
Rac protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
activation of JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation by virus of viral protein levels in host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
Names
butyrate-induced protein 1
butyrate-induced transcript 1
protein tyrosine phosphatase-like A domain containing 1
protein tyrosine phosphatase-like protein PTPLAD1
protein-tyrosine phosphatase-like A domain-containing protein 1
very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
NP_057479.2
XP_011519966.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016395.4NP_057479.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

    See identical proteins and their annotated locations for NP_057479.2

    Status: VALIDATED

    Source sequence(s)
    AC011846, AC027220
    Consensus CDS
    CCDS45282.1
    UniProtKB/Swiss-Prot
    Q9P035
    Related
    ENSP00000261875.5, ENST00000261875.10
    Conserved Domains (2) summary
    cd06465
    Location:8115
    p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
    pfam04387
    Location:195355
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65530463..65578355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521664.2XP_011519966.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform X1

    UniProtKB/TrEMBL
    H3BRL8
    Related
    ENSP00000456300.1, ENST00000566074.5
    Conserved Domains (1) summary
    pfam04387
    Location:78238
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
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