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SPOUT1 SPOUT domain containing methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 51490, updated on 4-Dec-2022

Summary

Official Symbol
SPOUT1provided by HGNC
Official Full Name
SPOUT domain containing methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:26933
See related
Ensembl:ENSG00000198917 MIM:617614; AllianceGenome:HGNC:26933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENP32; CENP-32; HSPC109; C9orf114
Summary
Enables miRNA binding activity. Involved in maintenance of centrosome location and production of miRNAs involved in gene silencing by miRNA. Located in kinetochore; mitotic spindle; and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 7.5), lymph node (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

See SPOUT1 in Genome Data Viewer
Location:
9q34.11
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128819651..128829794, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (141024452..141034597, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131581930..131592073, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr9.3033 Neighboring gene TBC1 domain family member 13 Neighboring gene endonuclease G Neighboring gene kynurenine aminotransferase 1 Neighboring gene Sharpr-MPRA regulatory region 9337 Neighboring gene Sharpr-MPRA regulatory region 7409

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough KYAT1-SPOUT1

Readthrough gene: KYAT1-SPOUT1, Included gene: KYAT1

Homology

Clone Names

  • MGC29492, DKFZp566D143

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of centrosome location IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maintenance of centrosome location IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
putative methyltransferase C9orf114
Names
centromere protein 32
kinetochore-associated protein
NP_057474.2
XP_047279415.1
XP_047279416.1
XP_047279417.1
XP_047279418.1
XP_047279419.1
XP_047279420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016390.4NP_057474.2  putative methyltransferase C9orf114

    See identical proteins and their annotated locations for NP_057474.2

    Status: VALIDATED

    Source sequence(s)
    AL110193, AL441992, BC046133, BC063644, BM997763
    Consensus CDS
    CCDS6913.1
    UniProtKB/Swiss-Prot
    Q5T280, Q6PJV9
    Related
    ENSP00000354812.5, ENST00000361256.10
    Conserved Domains (1) summary
    pfam02598
    Location:75364
    Methyltrn_RNA_3; Putative RNA methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128819651..128829794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423463.1XP_047279419.1  putative methyltransferase C9orf114 isoform X5

  2. XM_047423461.1XP_047279417.1  putative methyltransferase C9orf114 isoform X3

  3. XM_047423462.1XP_047279418.1  putative methyltransferase C9orf114 isoform X4

  4. XM_047423459.1XP_047279415.1  putative methyltransferase C9orf114 isoform X1

  5. XM_047423460.1XP_047279416.1  putative methyltransferase C9orf114 isoform X2

  6. XM_047423464.1XP_047279420.1  putative methyltransferase C9orf114 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    141024452..141034597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)