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CLEC4E C-type lectin domain family 4 member E [ Bos taurus (domestic cattle) ]

Gene ID: 514797, updated on 30-Jan-2025
Official Symbol
CLEC4Eprovided by VGNC
Official Full Name
C-type lectin domain family 4 member Eprovided by VGNC
Primary source
VGNC:VGNC:27432
See related
BGD:BT11359; EnsemblRapid:ENSBTAG00070029932
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
all
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See CLEC4E in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (101699175..101714401, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene selenoprotein K pseudogene Neighboring gene C-type lectin domain family 4 member D Neighboring gene sodium/potassium-transporting ATPase subunit beta-3-like Neighboring gene CD163 molecule

Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle. Feinberg H, et al. J Biol Chem, 2016 Sep 30. PMID 27542410, Free PMC Article
  2. Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle. Feinberg H, et al. J Biol Chem, 2013 Oct 4. PMID 23960080, Free PMC Article
  3. Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves. Thakur A, et al. PLoS One, 2018. PMID 30063728, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves
    Title: Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves.
  2. The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-type carbohydrate recognition domain, also constrains the way the binding domains may interact on the surface of macrophages.
    Title: Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle.
  3. The data demonstrate how mincle bridges between the surfaces of the macrophage and the mycobacterium.
    Title: Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
C-type lectin domain family 4 member E
Names
mincle

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    101699175..101714401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059887086.1 → XP_059743069.1  C-type lectin domain family 4 member E isoform X1

    UniProtKB/TrEMBL
    E1BHM0

  2. XM_010805561.4 → XP_010803863.1  C-type lectin domain family 4 member E isoform X1

    See identical proteins and their annotated locations for XP_010803863.1

    UniProtKB/TrEMBL
    E1BHM0
    Related
    ENSBTAP00070041453.1, ENSBTAT00070067880.1
    Conserved Domains (1) summary
    cd03590
    Location:79 → 206
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

  3. XM_015471295.3 → XP_015326781.1  C-type lectin domain family 4 member E isoform X2

    Conserved Domains (1) summary
    cd03590
    Location:49 → 176
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

  4. XM_059887087.1 → XP_059743070.1  C-type lectin domain family 4 member E isoform X3

  5. XM_059887088.1 → XP_059743071.1  C-type lectin domain family 4 member E isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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