Format

Send to:

Choose Destination

EVL Enah/Vasp-like [ Homo sapiens (human) ]

Gene ID: 51466, updated on 11-Sep-2019

Summary

Official Symbol
EVLprovided by HGNC
Official Full Name
Enah/Vasp-likeprovided by HGNC
Primary source
HGNC:HGNC:20234
See related
Ensembl:ENSG00000196405 MIM:616912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNB6
Expression
Broad expression in lymph node (RPKM 31.5), spleen (RPKM 27.6) and 24 other tissues See more
Orthologs

Genomic context

See EVL in Genome Data Viewer
Location:
14q32.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (99971422..100144236)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (100485719..100610573)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724682 Neighboring gene RNA, U1 small nuclear 47, pseudogene Neighboring gene voltage dependent anion channel 3 pseudogene 1 Neighboring gene ribosomal protein S2 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 4628 Neighboring gene microRNA 151b Neighboring gene microRNA 342 Neighboring gene delta 4-desaturase, sphingolipid 2 Neighboring gene YY1 transcription factor Neighboring gene solute carrier family 25 member 29 Neighboring gene microRNA 6764

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with Enah/Vasp-like (EVL) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
    Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
  • TCR signaling, organism-specific biosystem (from REACTOME)
    TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
profilin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
profilin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization TAS
Traceable Author Statement
more info
PubMed 
actin nucleation IEA
Inferred from Electronic Annotation
more info
 
actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin polymerization or depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
animal organ morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ena/VASP-like protein
Names
ena/vasodilator-stimulated phosphoprotein-like
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330221.2NP_001317150.1  ena/VASP-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus.
    Source sequence(s)
    AL133368, BC023997, CX165372
    Consensus CDS
    CCDS81851.1
    UniProtKB/Swiss-Prot
    Q9UI08
    UniProtKB/TrEMBL
    A0A024R6K5
    Related
    ENSP00000384720.2, ENST00000402714.6
    Conserved Domains (2) summary
    cd01207
    Location:5113
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:378411
    VASP_tetra; VASP tetramerisation domain
  2. NM_016337.3NP_057421.1  ena/VASP-like protein isoform 1

    See identical proteins and their annotated locations for NP_057421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC032358, BQ083568
    Consensus CDS
    CCDS9955.1
    UniProtKB/Swiss-Prot
    Q9UI08
    Related
    ENSP00000376652.3, ENST00000392920.8
    Conserved Domains (2) summary
    cd01207
    Location:7115
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:380413
    VASP_tetra; VASP tetramerisation domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    99971422..100144236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536828.2XP_011535130.1  ena/VASP-like protein isoform X3

    Conserved Domains (1) summary
    cd01207
    Location:11119
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  2. XM_005267749.3XP_005267806.1  ena/VASP-like protein isoform X2

    Conserved Domains (3) summary
    cd01207
    Location:11119
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:384417
    VASP_tetra; VASP tetramerization domain
    pfam10265
    Location:283399
    DUF2217; Uncharacterized conserved protein (DUF2217)
  3. XM_017021363.2XP_016876852.1  ena/VASP-like protein isoform X1

    Related
    ENSP00000437904.2, ENST00000544450.6

RNA

  1. XR_001750360.1 RNA Sequence

  2. XR_001750355.1 RNA Sequence

  3. XR_001750356.1 RNA Sequence

  4. XR_001750362.1 RNA Sequence

  5. XR_001750363.1 RNA Sequence

  6. XR_001750366.1 RNA Sequence

  7. XR_001750364.1 RNA Sequence

  8. XR_001750357.2 RNA Sequence

  9. XR_001750359.2 RNA Sequence

  10. XR_001750367.1 RNA Sequence

  11. XR_001750361.1 RNA Sequence

  12. XR_002957557.1 RNA Sequence

Support Center