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EVL Enah/Vasp-like [ Homo sapiens (human) ]

Gene ID: 51466, updated on 17-Jun-2024

Summary

Official Symbol
EVLprovided by HGNC
Official Full Name
Enah/Vasp-likeprovided by HGNC
Primary source
HGNC:HGNC:20234
See related
Ensembl:ENSG00000196405 MIM:616912; AllianceGenome:HGNC:20234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNB6
Summary
Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 31.5), spleen (RPKM 27.6) and 24 other tissues See more
Orthologs
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Genomic context

See EVL in Genome Data Viewer
Location:
14q32.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (99971422..100144236)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (94204463..94377284)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (100437759..100610573)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100412450-100413378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100416877-100417378 Neighboring gene RNA, U1 small nuclear 47, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100434342-100434951 Neighboring gene Sharpr-MPRA regulatory region 1879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6072 Neighboring gene voltage dependent anion channel 3 pseudogene 1 Neighboring gene ribosomal protein S2 pseudogene 3 Neighboring gene uncharacterized LOC124903379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9018 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:100534710-100535909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9021 Neighboring gene uncharacterized LOC124903381 Neighboring gene microRNA 151b Neighboring gene microRNA 342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100604691-100605396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100605397-100606101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100611023-100611523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9025 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100613080-100613600 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100613601-100614119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6073 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6074 Neighboring gene uncharacterized LOC124903380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100632407-100632908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100632909-100633408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6075 Neighboring gene delta 4-desaturase, sphingolipid 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100680080-100680580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100684247-100684748 Neighboring gene Sharpr-MPRA regulatory region 8458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100698662-100699162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100699163-100699663 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100704543-100705395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6083 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:100711928-100712136 Neighboring gene YY1 transcription factor Neighboring gene microRNA 6764

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with Enah/Vasp-like (EVL) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables profilin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables profilin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane HDA PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ena/VASP-like protein
Names
ena/vasodilator-stimulated phosphoprotein-like
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330221.2NP_001317150.1  ena/VASP-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus.
    Source sequence(s)
    AL133368, BC023997, CX165372
    Consensus CDS
    CCDS81851.1
    UniProtKB/Swiss-Prot
    A8K105, B7Z3I5, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UI08, Q9UIC2
    UniProtKB/TrEMBL
    A0A024R6K5
    Related
    ENSP00000384720.2, ENST00000402714.6
    Conserved Domains (2) summary
    cd01207
    Location:5113
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:378411
    VASP_tetra; VASP tetramerisation domain
  2. NM_016337.3NP_057421.1  ena/VASP-like protein isoform 1

    See identical proteins and their annotated locations for NP_057421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC032358, BQ083568
    Consensus CDS
    CCDS9955.1
    UniProtKB/TrEMBL
    B4DW58
    Related
    ENSP00000376652.3, ENST00000392920.8
    Conserved Domains (2) summary
    cd01207
    Location:7115
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:380413
    VASP_tetra; VASP tetramerisation domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    99971422..100144236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431464.1XP_047287420.1  ena/VASP-like protein isoform X5

  2. XM_005267749.4XP_005267806.1  ena/VASP-like protein isoform X1

    Related
    ENSP00000437904.2, ENST00000544450.6
    Conserved Domains (3) summary
    cd01207
    Location:11119
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:384417
    VASP_tetra; VASP tetramerization domain
    pfam10265
    Location:283399
    DUF2217; Uncharacterized conserved protein (DUF2217)
  3. XM_047431462.1XP_047287418.1  ena/VASP-like protein isoform X3

  4. XM_011536828.3XP_011535130.1  ena/VASP-like protein isoform X6

    Conserved Domains (1) summary
    cd01207
    Location:11119
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
  5. XM_047431460.1XP_047287416.1  ena/VASP-like protein isoform X2

  6. XM_047431463.1XP_047287419.1  ena/VASP-like protein isoform X4

    UniProtKB/TrEMBL
    A0A2D1PGY7
  7. XM_047431465.1XP_047287421.1  ena/VASP-like protein isoform X7

RNA

  1. XR_007064013.1 RNA Sequence

  2. XR_007064014.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    94204463..94377284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376198.1XP_054232173.1  ena/VASP-like protein isoform X1

  2. XM_054376200.1XP_054232175.1  ena/VASP-like protein isoform X3

  3. XM_054376202.1XP_054232177.1  ena/VASP-like protein isoform X6

  4. XM_054376201.1XP_054232176.1  ena/VASP-like protein isoform X4

    UniProtKB/TrEMBL
    A0A2D1PGY7
  5. XM_054376199.1XP_054232174.1  ena/VASP-like protein isoform X2

  6. XM_054376203.1XP_054232178.1  ena/VASP-like protein isoform X7

RNA

  1. XR_008488872.1 RNA Sequence

  2. XR_008488873.1 RNA Sequence