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GPR89B G protein-coupled receptor 89B [ Homo sapiens (human) ]

Gene ID: 51463, updated on 4-Jun-2020

Summary

Official Symbol
GPR89Bprovided by HGNC
Official Full Name
G protein-coupled receptor 89Bprovided by HGNC
Primary source
HGNC:HGNC:13840
See related
Ensembl:ENSG00000188092 MIM:612806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPHR; GPR89; SH120; GPR89C; UNQ192
Annotation information
Note: There are multiple copies of the sequence G protein-coupled receptor 89 in the human genome. After consultation with the HUGO Gene Nomenclature committee, the symbol GPR89B was assigned to the most telomeric locus. [06 Jun 2007]
Expression
Ubiquitous expression in kidney (RPKM 17.6), testis (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See GPR89B in Genome Data Viewer
Location:
1q21.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (147928374..147993592)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (147400506..147465753)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 17 pseudogene Neighboring gene uncharacterized LOC105371229 Neighboring gene gap junction protein alpha 8 Neighboring gene PDZ domain containing 1 pseudogene 1 Neighboring gene tRNA-Arg (anticodon CCT) 6-2 Neighboring gene long intergenic non-protein coding RNA 2804 Neighboring gene RNA, U1 small nuclear 129, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ55546, FLJ61382

Gene Ontology Provided by GOA

Function Evidence Code Pubs
voltage-gated anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
intracellular pH reduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Golgi pH regulator B
Names
G protein-coupled receptor 89C
Golgi pH regulator A
protein GPR89
putative Golgi pH regulator C
putative MAPK-activating protein PM01
putative NF-kappa-B-activating protein 90
putative protein GPR89C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350180.1NP_001337109.1  Golgi pH regulator B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon structure in the 3' region compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL133020, AW002571, AW137222, DB524598, DC412954, U78723
    Consensus CDS
    CCDS930.1
    Conserved Domains (2) summary
    pfam12430
    Location:276444
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:140207
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  2. NM_001350181.1NP_001337110.1  Golgi pH regulator B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AL133020, AW002571, AW137222, DB459108, DC412954, U78723
    Conserved Domains (2) summary
    pfam12430
    Location:251419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  3. NM_001350182.1NP_001337111.1  Golgi pH regulator B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AL133020, AW002571, AW137222, DC345007, DC412954, U78723
    Conserved Domains (2) summary
    pfam12430
    Location:251419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  4. NM_001350183.1NP_001337112.1  Golgi pH regulator B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AL133020, AW002571, AW137222, DA922006, DC412954, U78723
    Conserved Domains (2) summary
    pfam12430
    Location:156324
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:2087
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  5. NM_001350184.1NP_001337113.1  Golgi pH regulator B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon and uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3)
    Source sequence(s)
    AL133020, AW002571, AW137222, DA065783, DA922006, DC412954, U78723
    Conserved Domains (2) summary
    pfam12430
    Location:156324
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:2087
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  6. NM_016334.5NP_057418.1  Golgi pH regulator B isoform 1

    See identical proteins and their annotated locations for NP_057418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL133020, AW002571, AW137222, U78723
    Consensus CDS
    CCDS930.1
    UniProtKB/Swiss-Prot
    B7ZAQ6, P0CG08
    UniProtKB/TrEMBL
    X5D7G6
    Related
    ENSP00000358233.4, ENST00000314163.12
    Conserved Domains (2) summary
    pfam12430
    Location:276444
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:140207
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    147928374..147993592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001449.1XP_016856938.1  Golgi pH regulator B isoform X3

  2. XM_011509613.2XP_011507915.1  Golgi pH regulator B isoform X4

    See identical proteins and their annotated locations for XP_011507915.1

    UniProtKB/Swiss-Prot
    P0CG08
    Related
    ENSP00000475253.1, ENST00000468618.6
    Conserved Domains (1) summary
    pfam12537
    Location:140207
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  3. XM_017001448.2XP_016856937.1  Golgi pH regulator B isoform X1

    UniProtKB/Swiss-Prot
    B7ZAQ6
    Conserved Domains (2) summary
    pfam12430
    Location:251419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  4. XM_005277402.4XP_005277459.1  Golgi pH regulator B isoform X1

    See identical proteins and their annotated locations for XP_005277459.1

    UniProtKB/Swiss-Prot
    B7ZAQ6
    Conserved Domains (2) summary
    pfam12430
    Location:251419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
  5. XM_011509612.2XP_011507914.1  Golgi pH regulator B isoform X2

    See identical proteins and their annotated locations for XP_011507914.1

    UniProtKB/Swiss-Prot
    B7ZAQ6
    Conserved Domains (2) summary
    pfam12430
    Location:156324
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:2087
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

RNA

  1. XR_001737221.1 RNA Sequence

    Related
    ENST00000488165.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001097616.1: Suppressed sequence

    Description
    NM_001097616.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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