ERAP1 endoplasmic reticulum aminopeptidase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ERAP1provided by VGNC
Official Full Name: endoplasmic reticulum aminopeptidase 1provided by VGNC
Primary source: VGNC:VGNC:28560
See related: BGD:BT15452; EnsemblRapid:ENSBTAG00070000399
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (96168784..96298585, complement)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against Bovine Tuberculosis.
Title: ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in peptide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: endoplasmic reticulum aminopeptidase 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102003.1 → NP_001095473.1 endoplasmic reticulum aminopeptidase 1 precursor

See identical proteins and their annotated locations for NP_001095473.1

Status: PROVISIONAL

Source sequence(s)

BC151388

UniProtKB/TrEMBL

A0A3Q1MTA2, A7MB81

Related

ENSBTAP00070000540.1, ENSBTAT00070000854.1

Conserved Domains (3) summary

cd09601
Location:63 → 532

M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)

pfam01433
Location:54 → 442

Peptidase_M1; Peptidase family M1

pfam11838
Location:599 → 915

ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

Range

96168784..96298585 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059888137.1 → XP_059744120.1 endoplasmic reticulum aminopeptidase 1 isoform X1

UniProtKB/TrEMBL

A0A3Q1MTA2, F1MU34
XM_059888138.1 → XP_059744121.1 endoplasmic reticulum aminopeptidase 1 isoform X1

UniProtKB/TrEMBL

A0A3Q1MTA2, F1MU34
XM_010807625.4 → XP_010805927.1 endoplasmic reticulum aminopeptidase 1 isoform X1

See identical proteins and their annotated locations for XP_010805927.1

UniProtKB/TrEMBL

A0A3Q1MTA2, F1MU34

Conserved Domains (2) summary

cd09601
Location:63 → 532

M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)

pfam11838
Location:598 → 917

ERAP1_C; ERAP1-like C-terminal domain
XM_024994198.2 → XP_024849966.1 endoplasmic reticulum aminopeptidase 1 isoform X1

UniProtKB/TrEMBL

A0A3Q1MTA2, F1MU34

Conserved Domains (2) summary

cd09601
Location:63 → 532

M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)

pfam11838
Location:598 → 917

ERAP1_C; ERAP1-like C-terminal domain
XM_024994197.2 → XP_024849965.1 endoplasmic reticulum aminopeptidase 1 isoform X1

UniProtKB/TrEMBL

A0A3Q1MTA2, F1MU34

Conserved Domains (2) summary

cd09601
Location:63 → 532

M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)

pfam11838
Location:598 → 917

ERAP1_C; ERAP1-like C-terminal domain