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RHCG Rh family C glycoprotein [ Homo sapiens (human) ]

Gene ID: 51458, updated on 7-Apr-2025

Summary

Official Symbol
RHCGprovided by HGNC
Official Full Name
Rh family C glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:18140
See related
Ensembl:ENSG00000140519 MIM:605381; AllianceGenome:HGNC:18140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RHGK; PDRC2; C15orf6; SLC42A3
Summary
Enables several functions, including ammonium channel activity; ankyrin binding activity; and carbon dioxide transmembrane transporter activity. Involved in ammonium transmembrane transport; intracellular monoatomic ion homeostasis; and transepithelial ammonium transport. Located in apical plasma membrane and basolateral plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Restricted expression toward esophagus (RPKM 1491.4) See more
Orthologs
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Genomic context

See RHCG in Genome Data Viewer
Location:
15q26.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (89471407..89496583, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87227437..87252613, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90014638..90039814, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89943355-89943880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89943881-89944405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10052 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:89950909-89951506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89959457-89959966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89959967-89960475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89977117-89977646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89984167-89984846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89984847-89985526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89988016-89988870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89991872-89992466 Neighboring gene uncharacterized LOC105370964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6798 Neighboring gene uncharacterized LOC112268153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90029819-90030319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90035105-90035610 Neighboring gene long intergenic non-protein coding RNA 928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90119099-90119627 Neighboring gene TOPBP1 interacting checkpoint and replication regulator Neighboring gene kinesin family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ammonium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ammonium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ammonium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ammonium channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables ammonium channel activity TAS
Traceable Author Statement
more info
 
enables ankyrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables carbon dioxide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amine transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ammonium homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ammonium transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ammonium transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ammonium transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ammonium transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in carbon dioxide transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in homeostatic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intracellular monoatomic ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
 
involved_in transepithelial ammonium transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ammonium transporter Rh type C
Names
Rh type C glycoprotein
Rhesus blood group, C glycoprotein
rh family type C glycoprotein
rh glycoprotein kidney
rhesus blood group family type C glycoprotein
tumor-related protein DRC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321041.2NP_001307970.1  ammonium transporter Rh type C

    Status: VALIDATED

    Source sequence(s)
    AK313238, BC015461
    Consensus CDS
    CCDS10351.1
    UniProtKB/Swiss-Prot
    A8K4D4, Q6X3Y4, Q9UBD6
    UniProtKB/TrEMBL
    B4DPA5
    Conserved Domains (1) summary
    cl03012
    Location:60435
    Ammonium_transp; Ammonium Transporter Family
  2. NM_016321.3NP_057405.1  ammonium transporter Rh type C

    See identical proteins and their annotated locations for NP_057405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes a protein.
    Source sequence(s)
    AF193809, BC030965, DC306265
    Consensus CDS
    CCDS10351.1
    UniProtKB/Swiss-Prot
    A8K4D4, Q6X3Y4, Q9UBD6
    UniProtKB/TrEMBL
    B4DPA5
    Related
    ENSP00000268122.4, ENST00000268122.9
    Conserved Domains (1) summary
    cl03012
    Location:60435
    Ammonium_transp; Ammonium Transporter Family

RNA

  1. NR_110261.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the use of an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF193809, BC015461, DC306265
    Related
    ENST00000560081.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    89471407..89496583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432651.1XP_047288607.1  ammonium transporter Rh type C isoform X1

    UniProtKB/Swiss-Prot
    A8K4D4, Q6X3Y4, Q9UBD6
    UniProtKB/TrEMBL
    B4DPA5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    87227437..87252613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378166.1XP_054234141.1  ammonium transporter Rh type C isoform X1

    UniProtKB/Swiss-Prot
    A8K4D4, Q6X3Y4, Q9UBD6
    UniProtKB/TrEMBL
    B4DPA5