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REV1 REV1 DNA directed polymerase [ Homo sapiens (human) ]

Gene ID: 51455, updated on 9-Feb-2026
Official Symbol
REV1provided by HGNC
Official Full Name
REV1 DNA directed polymeraseprovided by HGNC
Primary source
HGNC:HGNC:14060
See related
Ensembl:ENSG00000135945 MIM:606134; AllianceGenome:HGNC:14060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REV1L; AIBP80
Summary
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in endometrium (RPKM 6.5), testis (RPKM 6.4) and 25 other tissues See more
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See REV1 in Genome Data Viewer
Location:
2q11.2
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (99400477..99490202, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99859127..99948858, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (100016940..100106479, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99952564-99953104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99953733-99954234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99954235-99954734 Neighboring gene thioredoxin domain containing 9 Neighboring gene lysozyme g1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:100019841-100021040 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11809 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:100056357-100057026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:100092059-100092722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16288 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:100106417-100107302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100146131-100146758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100170377-100170925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100170926-100171473 Neighboring gene NANOG hESC enhancer GRCh37_chr2:100171857-100172363 Neighboring gene NANOG hESC enhancer GRCh37_chr2:100188674-100189175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:100218069-100218631 Neighboring gene ALF transcription elongation factor 3 Neighboring gene uncharacterized LOC124906051 Neighboring gene uncharacterized LOC105373504

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ21523, MGC26225, MGC163283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-(abasic site) binding IC
Inferred by Curator
more info
PubMed 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding IC
Inferred by Curator
more info
PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables deoxycytidyl transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables deoxycytidyl transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deoxycytidyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables deoxycytidyl transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables deoxycytidyl transferase activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in error-prone translesion synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in error-prone translesion synthesis TAS
Traceable Author Statement
more info
PubMed 
involved_in somatic hypermutation of immunoglobulin genes IDA
Inferred from Direct Assay
more info
PubMed 
involved_in somatic hypermutation of immunoglobulin genes IEA
Inferred from Electronic Annotation
more info
 
involved_in translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear replication fork IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in site of DNA damage IC
Inferred by Curator
more info
PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
translesion synthesis protein REV1; DNA repair protein REV1
Names
REV1 homolog
REV1, polymerase (DNA directed)
REV1- like
alpha integrin-binding protein 80
molecular adapter protein REV1
rev1-like terminal deoxycytidyl transferase
reversionless protein 1 homolog
template-dependent deoxycytidyl transferase REV1
NP_001032961.1
NP_001308383.1
NP_001308384.1
NP_001308387.1
NP_001308388.1
NP_001308389.1
NP_057400.1
XP_011509643.1
XP_016859798.1
XP_016859799.2
XP_016859800.1
XP_016859801.1
XP_016859802.1
XP_047300673.1
XP_047300674.1
XP_047300675.1
XP_047300676.1
XP_047300677.1
XP_047300679.1
XP_047300680.1
XP_047300681.1
XP_054198479.1
XP_054198480.1
XP_054198481.1
XP_054198482.1
XP_054198483.1
XP_054198484.1
XP_054198485.1
XP_054198486.1
XP_054198487.1
XP_054198488.1
XP_054198489.1
XP_054198490.1
XP_054198491.1
XP_054198492.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037872.3NP_001032961.1  translesion synthesis protein REV1 isoform 2

    See identical proteins and their annotated locations for NP_001032961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AB047646, BM683065, HY010913
    Consensus CDS
    CCDS42722.1
    UniProtKB/TrEMBL
    A1L461
    Related
    ENSP00000377091.3, ENST00000393445.7
    Conserved Domains (4) summary
    cd01701
    Location:348823
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:9381056
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:11291249
    REV1_C; DNA repair protein REV1 C-terminal domain
  2. NM_001321454.2NP_001308383.1  translesion synthesis protein REV1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AF206019, BM683065, DA304601
    UniProtKB/TrEMBL
    A1L461
    Related
    ENSP00000549723.1, ENST00000879664.1
    Conserved Domains (4) summary
    cd01701
    Location:348860
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:9751093
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:11661286
    REV1_C; DNA repair protein REV1 C-terminal domain
  3. NM_001321455.2NP_001308384.1  translesion synthesis protein REV1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB047646, AC018690, BC037734, BM683065, HY010913
    UniProtKB/TrEMBL
    A1L461
    Conserved Domains (4) summary
    cd01701
    Location:278753
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:448
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:868986
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:10591179
    REV1_C; DNA repair protein REV1 C-terminal domain
  4. NM_001321458.2NP_001308387.1  translesion synthesis protein REV1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB047646, AC018690, BM683065, DA304601, HY010913
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Conserved Domains (3) summary
    cd01701
    Location:27334
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:449567
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:640760
    REV1_C; DNA repair protein REV1 C-terminal domain
  5. NM_001321459.2NP_001308388.1  translesion synthesis protein REV1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) and variant 7 both encode the same isoform (6).
    Source sequence(s)
    AC018690, AF206019, BM683065, BP269179
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Conserved Domains (3) summary
    cd01701
    Location:1301
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:416534
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:600727
    REV1_C; DNA repair protein REV1 C-terminal domain
  6. NM_001321460.2NP_001308389.1  translesion synthesis protein REV1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) and variant 6 both encode the same isoform (6).
    Source sequence(s)
    AB047646, AC018690, BM683065, BP269179, HY010913
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Related
    ENSP00000590336.1, ENST00000920277.1
    Conserved Domains (3) summary
    cd01701
    Location:1301
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:416534
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:600727
    REV1_C; DNA repair protein REV1 C-terminal domain
  7. NM_016316.4NP_057400.1  translesion synthesis protein REV1 isoform 1

    See identical proteins and their annotated locations for NP_057400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC018690, AF151538, BM683065, HY010913
    Consensus CDS
    CCDS2045.1
    UniProtKB/Swiss-Prot
    O95941, Q53SI7, Q9C0J4, Q9NUP2, Q9UBZ9
    UniProtKB/TrEMBL
    A1L461
    Related
    ENSP00000258428.3, ENST00000258428.8
    Conserved Domains (4) summary
    cd01701
    Location:348824
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:9391057
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:11301250
    REV1_C; DNA repair protein REV1 C-terminal domain

RNA

  1. NR_135649.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018690, AK025176, BF934582, BM683065, BP269179, BP332286, CA951106, CK300059, CR736537, DA407212, DA852908, DR000409, HY010913
  2. NR_135650.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018690, BC037734, BM683065
    Related
    ENST00000413697.5
  3. NR_135651.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB047646, BM683065, HY010913
  4. NR_135652.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF206019, BC037734, BM683065
  5. NR_135653.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF206019, BM683065

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    99400477..99490202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004311.2XP_016859800.1  DNA repair protein REV1 isoform X6

    UniProtKB/TrEMBL
    A1L461
    Conserved Domains (4) summary
    cd01701
    Location:348860
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:9751093
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:11661286
    REV1_C; DNA repair protein REV1 C-terminal domain
  2. XM_047444723.1XP_047300679.1  DNA repair protein REV1 isoform X10

    UniProtKB/TrEMBL
    A1L461
    Related
    ENSP00000619124.1, ENST00000949065.1
  3. XM_047444721.1XP_047300677.1  DNA repair protein REV1 isoform X9

    UniProtKB/Swiss-Prot
    O95941, Q53SI7, Q9C0J4, Q9NUP2, Q9UBZ9
    UniProtKB/TrEMBL
    A1L461
    Related
    ENSP00000549722.1, ENST00000879663.1
  4. XM_047444719.1XP_047300675.1  DNA repair protein REV1 isoform X7

    UniProtKB/TrEMBL
    A1L461
  5. XM_017004312.3XP_016859801.1  DNA repair protein REV1 isoform X7

    UniProtKB/TrEMBL
    A1L461
    Related
    ENSP00000549724.1, ENST00000879665.1
    Conserved Domains (3) summary
    cd01701
    Location:348859
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:11921285
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
  6. XM_047444717.1XP_047300673.1  DNA repair protein REV1 isoform X2

    UniProtKB/TrEMBL
    A1L461
  7. XM_017004309.3XP_016859798.1  DNA repair protein REV1 isoform X5

    UniProtKB/TrEMBL
    A1L461
  8. XM_017004310.2XP_016859799.2  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    A1L461
  9. XM_017004313.2XP_016859802.1  DNA repair protein REV1 isoform X4

    UniProtKB/TrEMBL
    A1L461
  10. XM_047444720.1XP_047300676.1  DNA repair protein REV1 isoform X8

    UniProtKB/TrEMBL
    A1L461
  11. XM_047444718.1XP_047300674.1  DNA repair protein REV1 isoform X3

    UniProtKB/TrEMBL
    A1L461
  12. XM_047444724.1XP_047300680.1  DNA repair protein REV1 isoform X11

    UniProtKB/TrEMBL
    A1L461
  13. XM_011511341.3XP_011509643.1  DNA repair protein REV1 isoform X12

    See identical proteins and their annotated locations for XP_011509643.1

    Conserved Domains (3) summary
    cd01701
    Location:27334
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:449567
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:640760
    REV1_C; DNA repair protein REV1 C-terminal domain
  14. XM_047444725.1XP_047300681.1  DNA repair protein REV1 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    99859127..99948858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342509.1XP_054198484.1  DNA repair protein REV1 isoform X6

    UniProtKB/TrEMBL
    A1L461
  2. XM_054342514.1XP_054198489.1  DNA repair protein REV1 isoform X10

    UniProtKB/TrEMBL
    A1L461
  3. XM_054342513.1XP_054198488.1  DNA repair protein REV1 isoform X9

    UniProtKB/Swiss-Prot
    O95941, Q53SI7, Q9C0J4, Q9NUP2, Q9UBZ9
    UniProtKB/TrEMBL
    A1L461
  4. XM_054342511.1XP_054198486.1  DNA repair protein REV1 isoform X7

    UniProtKB/TrEMBL
    A1L461
  5. XM_054342510.1XP_054198485.1  DNA repair protein REV1 isoform X7

    UniProtKB/TrEMBL
    A1L461
  6. XM_054342505.1XP_054198480.1  DNA repair protein REV1 isoform X2

    UniProtKB/TrEMBL
    A1L461
  7. XM_054342508.1XP_054198483.1  DNA repair protein REV1 isoform X5

    UniProtKB/TrEMBL
    A1L461
  8. XM_054342504.1XP_054198479.1  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    A1L461
  9. XM_054342507.1XP_054198482.1  DNA repair protein REV1 isoform X4

    UniProtKB/TrEMBL
    A1L461
  10. XM_054342512.1XP_054198487.1  DNA repair protein REV1 isoform X8

    UniProtKB/TrEMBL
    A1L461
  11. XM_054342506.1XP_054198481.1  DNA repair protein REV1 isoform X3

    UniProtKB/TrEMBL
    A1L461
  12. XM_054342515.1XP_054198490.1  DNA repair protein REV1 isoform X11

    UniProtKB/TrEMBL
    A1L461
  13. XM_054342516.1XP_054198491.1  DNA repair protein REV1 isoform X12

  14. XM_054342517.1XP_054198492.1  DNA repair protein REV1 isoform X13