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REV1 REV1 DNA directed polymerase [ Homo sapiens (human) ]

Gene ID: 51455, updated on 16-Oct-2021

Summary

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Official Symbol
REV1provided by HGNC
Official Full Name
REV1 DNA directed polymeraseprovided by HGNC
Primary source
HGNC:HGNC:14060
See related
Ensembl:ENSG00000135945 MIM:606134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REV1L; AIBP80
Summary
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in endometrium (RPKM 6.5), testis (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

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See REV1 in Genome Data Viewer
Location:
2q11.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (99400477..99490123, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (100016940..100106479, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985923 Neighboring gene thioredoxin domain containing 9 Neighboring gene lysozyme g1 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene AF4/FMR2 family member 3 Neighboring gene uncharacterized LOC105373504 Neighboring gene uncharacterized LOC112268421

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Ketkar A, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33555350, Free PMC Article
  2. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Yeom M, et al. Chem Res Toxicol, 2016 Mar 21. PMID 26914252, Free PMC Article
  3. Human Rev1 polymerase disrupts G-quadruplex DNA. Eddy S, et al. Nucleic Acids Res, 2014 Mar. PMID 24366879, Free PMC Article
  4. Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain. Liu D, et al. J Mol Cell Biol, 2013 Jun. PMID 23220741
  5. Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. Choi JY, et al. J Mol Biol, 2010 Nov 19. PMID 20888339, Free PMC Article

See all (90) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs.
    Title: Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs.
  2. Exome Sequencing in Individuals with Isolated Biliary Atresia.
    Title: Exome Sequencing in Individuals with Isolated Biliary Atresia.
  3. elevated expression of Rev1 alone is sufficient to confer enhanced UV-damage tolerance and that this tolerance depends on its physical interaction with monoubiquitinated PCNA and Polzeta but is independent of Poleta.
    Title: Rev1 plays central roles in mammalian DNA-damage tolerance in response to UV irradiation.
  4. Study reports the solution NMR structure of a 108-residue fragment of human REV1 encompassing the two putative ubiquitin-binding motifs UBM1 and UBM2 in complex with ubiquitin. While in mammals UBM1 and UBM2 are both required for optimal association of REV1 with replication factories after DNA damage, only REV1 UBM2 binds ubiquitin.
    Title: Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.
  5. RAD51 regulates REV1 recruitment to DNA double-strand break sites via pulsed laser microirradiation.
    Title: [RAD51 regulates REV1 recruitment to DNA double-strand <br/>break sites].
  6. results provide insights into the structure of the Rev1/Polzeta TLS assembly and highlight the function of Rev7 homo- and heterodimerization.
    Title: Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex.
  7. These data indicate that dysregulation of cellular Rev1 levels leads to the accumulation of mutations and suppression of cell death, which accelerates the tumorigenic activities of DNA-damaging agents.
    Title: Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.
  8. The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase.
    Title: Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.
  9. the catalytic function of REV1 is moderately or slightly altered by at least nine genetic variations, and the G4 DNA processing function of REV1 is slightly enhanced by the N373S variation, which might provide the possibility that certain germline missense REV1 variations affect the individual susceptibility to carcinogenesis by modifying the capability of REV1 for replicative bypass past DNA lesions and G4 motifs derived
    Title: Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1.
  10. REV1 can promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
    Title: REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21523, MGC26225, MGC163283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables deoxycytidyl transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables deoxycytidyl transferase activity TAS
Traceable Author Statement
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in error-prone translesion synthesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
DNA repair protein REV1
Names
REV1 homolog
REV1, polymerase (DNA directed)
REV1- like
alpha integrin-binding protein 80
rev1-like terminal deoxycytidyl transferase
NP_001032961.1
NP_001308383.1
NP_001308384.1
NP_001308387.1
NP_001308388.1
NP_001308389.1
NP_057400.1
XP_011509643.1
XP_016859798.1
XP_016859799.1
XP_016859800.1
XP_016859801.1
XP_016859802.1
XP_016859803.1
XP_016859804.1
XP_024308728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037872.3 → NP_001032961.1  DNA repair protein REV1 isoform 2

    See identical proteins and their annotated locations for NP_001032961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AB047646, BM683065, HY010913
    Consensus CDS
    CCDS42722.1
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Related
    ENSP00000377091.3, ENST00000393445.7
    Conserved Domains (4) summary
    cd01701
    Location:348 → 823
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46 → 118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:938 → 1056
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:1129 → 1249
    REV1_C; DNA repair protein REV1 C-terminal domain

  2. NM_001321454.2 → NP_001308383.1  DNA repair protein REV1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AF206019, BM683065, DA304601
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Conserved Domains (4) summary
    cd01701
    Location:348 → 860
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46 → 118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:975 → 1093
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:1166 → 1286
    REV1_C; DNA repair protein REV1 C-terminal domain

  3. NM_001321455.2 → NP_001308384.1  DNA repair protein REV1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB047646, AC018690, BC037734, BM683065, HY010913
    UniProtKB/Swiss-Prot
    Q9UBZ9
    UniProtKB/TrEMBL
    Q49AI5
    Conserved Domains (4) summary
    cd01701
    Location:278 → 753
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:4 → 48
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:868 → 986
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:1059 → 1179
    REV1_C; DNA repair protein REV1 C-terminal domain

  4. NM_001321458.2 → NP_001308387.1  DNA repair protein REV1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB047646, AC018690, BM683065, DA304601, HY010913
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Conserved Domains (3) summary
    cd01701
    Location:27 → 334
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:449 → 567
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:640 → 760
    REV1_C; DNA repair protein REV1 C-terminal domain

  5. NM_001321459.2 → NP_001308388.1  DNA repair protein REV1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) and variant 7 both encode the same isoform (6).
    Source sequence(s)
    AC018690, AF206019, BM683065, BP269179
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Conserved Domains (3) summary
    cd01701
    Location:1 → 301
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:416 → 534
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:600 → 727
    REV1_C; DNA repair protein REV1 C-terminal domain

  6. NM_001321460.2 → NP_001308389.1  DNA repair protein REV1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) and variant 6 both encode the same isoform (6).
    Source sequence(s)
    AB047646, AC018690, BM683065, BP269179, HY010913
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Conserved Domains (3) summary
    cd01701
    Location:1 → 301
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:416 → 534
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:600 → 727
    REV1_C; DNA repair protein REV1 C-terminal domain

  7. NM_016316.4 → NP_057400.1  DNA repair protein REV1 isoform 1

    See identical proteins and their annotated locations for NP_057400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC018690, AF151538, BM683065, HY010913
    Consensus CDS
    CCDS2045.1
    UniProtKB/Swiss-Prot
    Q9UBZ9
    Related
    ENSP00000258428.3, ENST00000258428.8
    Conserved Domains (4) summary
    cd01701
    Location:348 → 824
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46 → 118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:939 → 1057
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:1130 → 1250
    REV1_C; DNA repair protein REV1 C-terminal domain

RNA

  1. NR_135649.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018690, AK025176, BF934582, BM683065, BP269179, BP332286, CA951106, CK300059, CR736537, DA407212, DA852908, DR000409, HY010913

  2. NR_135650.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018690, BC037734, BM683065
    Related
    ENST00000413697.5

  3. NR_135651.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB047646, BM683065, HY010913

  4. NR_135652.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF206019, BC037734, BM683065

  5. NR_135653.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF206019, BM683065

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    99400477..99490123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004311.1 → XP_016859800.1  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:348 → 860
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46 → 118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:975 → 1093
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:1166 → 1286
    REV1_C; DNA repair protein REV1 C-terminal domain

  2. XM_017004312.2 → XP_016859801.1  DNA repair protein REV1 isoform X3

    Conserved Domains (3) summary
    cd01701
    Location:348 → 859
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1192 → 1285
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins

  3. XM_024452960.1 → XP_024308728.1  DNA repair protein REV1 isoform X7

    Conserved Domains (3) summary
    cd01701
    Location:1 → 301
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:416 → 534
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:600 → 727
    REV1_C; DNA repair protein REV1 C-terminal domain

  4. XM_017004309.2 → XP_016859798.1  DNA repair protein REV1 isoform X1

  5. XM_017004313.1 → XP_016859802.1  DNA repair protein REV1 isoform X4

  6. XM_017004310.1 → XP_016859799.1  DNA repair protein REV1 isoform X2

    Conserved Domains (4) summary
    cd01701
    Location:348 → 860
    PolY_Rev1; DNA polymerase Rev1
    smart00292
    Location:46 → 118
    BRCT; breast cancer carboxy-terminal domain
    pfam14377
    Location:975 → 1093
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:1166 → 1286
    REV1_C; DNA repair protein REV1 C-terminal domain

  7. XM_017004314.2 → XP_016859803.1  DNA repair protein REV1 isoform X5

    Conserved Domains (3) summary
    cd01701
    Location:27 → 334
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:449 → 567
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:640 → 760
    REV1_C; DNA repair protein REV1 C-terminal domain

  8. XM_017004315.2 → XP_016859804.1  DNA repair protein REV1 isoform X6

  9. XM_011511341.2 → XP_011509643.1  DNA repair protein REV1 isoform X5

    See identical proteins and their annotated locations for XP_011509643.1

    Conserved Domains (3) summary
    cd01701
    Location:27 → 334
    PolY_Rev1; DNA polymerase Rev1
    pfam14377
    Location:449 → 567
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:640 → 760
    REV1_C; DNA repair protein REV1 C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UBZ9.1 GenPept UniProtKB/Swiss-Prot:Q9UBZ9

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