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CBS cystathionine beta-synthase [ Bos taurus (cattle) ]

Gene ID: 514525, updated on 5-Mar-2024

Summary

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Official Symbol
CBSprovided by VGNC
Official Full Name
cystathionine beta-synthaseprovided by VGNC
Primary source
VGNC:VGNC:108974
See related
BGD:BT21351; Ensembl:ENSBTAG00000000160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (143219507..143242399, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit V3 Neighboring gene uncharacterized LOC132345932 Neighboring gene PBX/knotted 1 homeobox 1 Neighboring gene U2 small nuclear RNA auxiliary factor 1 Neighboring gene crystallin alpha A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for the evolutionary origin of human chromosome 21 from comparative gene mapping in the cow and mouse. Threadgill DS, et al. Proc Natl Acad Sci U S A, 1991 Jan 1. PMID 1986361, Free PMC Article
  2. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β(1): Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways. Takahashi M, et al. Int J Mol Sci, 2021 Oct 29. PMID 34769192, Free PMC Article
  3. Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline. Zhou Z, et al. J Nutr, 2017 Jan. PMID 27881594
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-beta1: Induction of Cystathionine gamma-Lyase and Cystathionine beta-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways.
    Title: Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β(1): Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways.
  2. These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
    Title: Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC179463

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cystathionine beta-synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cysteine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cysteine biosynthetic process via cystathionine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cystathionine beta-synthase
NP_001095470.1
XP_010799955.1
XP_024841382.1
XP_059737911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102000.2 → NP_001095470.1  cystathionine beta-synthase

    See identical proteins and their annotated locations for NP_001095470.1

    Status: PROVISIONAL

    Source sequence(s)
    BC151539
    UniProtKB/TrEMBL
    A7MBF8
    Conserved Domains (3) summary
    cd01561
    Location:87 → 385
    CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
    cd04608
    Location:421 → 545
    CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
    TIGR01137
    Location:78 → 546
    cysta_beta; cystathionine beta-synthase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    143219507..143242399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024985614.2 → XP_024841382.1  cystathionine beta-synthase isoform X3

    Related
    ENSBTAP00000000184.5, ENSBTAT00000000184.6
    Conserved Domains (1) summary
    TIGR01137
    Location:78 → 560
    cysta_beta; cystathionine beta-synthase

  2. XM_010801653.4 → XP_010799955.1  cystathionine beta-synthase isoform X1

    See identical proteins and their annotated locations for XP_010799955.1

    UniProtKB/TrEMBL
    F1MEW4
    Related
    ENSBTAP00000063539.2, ENSBTAT00000087445.2
    Conserved Domains (3) summary
    cd01561
    Location:87 → 385
    CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
    cd04608
    Location:421 → 545
    CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
    TIGR01137
    Location:78 → 546
    cysta_beta; cystathionine beta-synthase

  3. XM_059881928.1 → XP_059737911.1  cystathionine beta-synthase isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials
Miscellaneous