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LCMT1 leucine carboxyl methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 51451, updated on 7-Dec-2018

Summary

Official Symbol
LCMT1provided by HGNC
Official Full Name
leucine carboxyl methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:17557
See related
Ensembl:ENSG00000205629 MIM:610286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCMT; PPMT1; CGI-68
Summary
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 19.0), brain (RPKM 15.0) and 25 other tissues See more
Orthologs

Genomic context

See LCMT1 in Genome Data Viewer
Location:
16p12.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (25111702..25178231)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (25123047..25189551)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene LCMT1 antisense RNA 1 Neighboring gene LCMT1 antisense RNA 2 Neighboring gene RNA, 7SL, cytoplasmic 557, pseudogene Neighboring gene aquaporin 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
C-terminal protein methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-terminal protein methylation IDA
Inferred from Direct Assay
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leucine carboxyl methyltransferase 1
Names
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
protein phosphatase methyltransferase 1
protein-leucine O-methyltransferase
NP_001027563.1
NP_057393.2
XP_005255411.1
XP_011544164.1
XP_011544166.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032391.1NP_001027563.1  leucine carboxyl methyltransferase 1 isoform b

    See identical proteins and their annotated locations for NP_001027563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate internal exons that encode an in-frame segment, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AL560574, BC001214, BF058787, BI459868
    Consensus CDS
    CCDS45446.1
    UniProtKB/Swiss-Prot
    Q9UIC8
    Related
    ENSP00000370353.4, ENST00000380966.8
    Conserved Domains (1) summary
    pfam04072
    Location:26162
    LCM; Leucine carboxyl methyltransferase
  2. NM_016309.3NP_057393.2  leucine carboxyl methyltransferase 1 isoform a

    See identical proteins and their annotated locations for NP_057393.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC001214, BI459868
    Consensus CDS
    CCDS45445.1
    UniProtKB/Swiss-Prot
    Q9UIC8
    Related
    ENSP00000382021.3, ENST00000399069.7
    Conserved Domains (1) summary
    pfam04072
    Location:26217
    LCM; Leucine carboxyl methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    25111702..25178231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255354.4XP_005255411.1  leucine carboxyl methyltransferase 1 isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:1117
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011545864.1XP_011544166.1  leucine carboxyl methyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011544166.1

    UniProtKB/Swiss-Prot
    Q9UIC8
    Conserved Domains (1) summary
    pfam04072
    Location:67240
    LCM; Leucine carboxyl methyltransferase
  3. XM_011545862.2XP_011544164.1  leucine carboxyl methyltransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam04072
    Location:67185
    LCM; Leucine carboxyl methyltransferase
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