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PRRX2 paired related homeobox 2 [ Homo sapiens (human) ]

Gene ID: 51450, updated on 12-Oct-2019

Summary

Official Symbol
PRRX2provided by HGNC
Official Full Name
paired related homeobox 2provided by HGNC
Primary source
HGNC:HGNC:21338
See related
Ensembl:ENSG00000167157 MIM:604675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMX2; PRX2
Summary
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in skin (RPKM 3.1), prostate (RPKM 3.0) and 17 other tissues See more
Orthologs

Genomic context

See PRRX2 in Genome Data Viewer
Location:
9q34.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (129665647..129722674)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132427920..132484953)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 50 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene ankyrin repeat and SOCS box containing 6 Neighboring gene PRRX2 antisense RNA 1 Neighboring gene prostaglandin E synthase Neighboring gene Sharpr-MPRA regulatory region 14524

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Web-based, participant-driven studies yield novel genetic associations for common traits.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19843

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
paired mesoderm homeobox protein 2
Names
PRX-2
paired-like homeodomain protein PRX2
paired-related homeobox protein 2
testicular tissue protein Li 148
testicular tissue protein Li 160

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016307.4NP_057391.1  paired mesoderm homeobox protein 2

    See identical proteins and their annotated locations for NP_057391.1

    Status: REVIEWED

    Source sequence(s)
    BC014645
    Consensus CDS
    CCDS6926.1
    UniProtKB/Swiss-Prot
    Q99811
    UniProtKB/TrEMBL
    A0A140VJS2
    Related
    ENSP00000361547.4, ENST00000372469.6
    Conserved Domains (1) summary
    pfam00046
    Location:109160
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    129665647..129722674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014803.1XP_016870292.1  paired mesoderm homeobox protein 2 isoform X1

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